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Biology and Biochemistry

D-Index
81
Citations
21388
World Ranking
3934
National Ranking
289

Overview

Oliver Werz is affiliated with Friedrich Schiller University Jena in Germany and has made contributions primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans several subfields including Molecular Biology, Pharmacology, Immunology, Organic Chemistry, and Biochemistry.

The principal topics of Werz's work focus on inflammatory mediators and NSAID effects, eicosanoids and hypertension pharmacology, immune response and inflammation, asthma and respiratory diseases, immune cells in cancer, fatty acid research and health, as well as synthesis and biological activity.

Werz's recent scholarly output includes several publications such as:

  • Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products, 2020, Nature Chemical Biology
  • The Atlas of Inflammation Resolution (AIR), 2020, Molecular Aspects of Medicine
  • SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction, 2021, Journal of Virology
  • Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans, 2020, Nature Metabolism
  • Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction, 2020, Cell Reports

Werz frequently publishes with a group of co-authors who have collaborated extensively. These include Paul M. Jordan, Andreas Koeberle, Simona Pace, Christian Kretzer, and R. Hofstetter.

The venues where Werz's work appears often include:

  • SSRN Electronic Journal
  • European Journal of Medicinal Chemistry
  • International Journal of Molecular Sciences
  • Biochemical Pharmacology
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • 5-Lipoxygenase: regulation of expression and enzyme activity

    Olof Rådmark;Oliver Werz;Dieter Steinhilber;Bengt Samuelsson

  • 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease.

    Olof Rådmark;Oliver Werz;Dieter Steinhilber;Bengt Samuelsson

  • The Nuclear Receptor for Melatonin Represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes

    Dieter Steinhilber;Martina Brungs;Oliver Werz;Irmgard Wiesenberg

  • Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data.

    Mona Abdel-Tawab;Oliver Werz;Manfred Schubert-Zsilavecz

  • Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase

    Dana Albert;Ilse Zündorf;Theo Dingermann;Walter E. Müller

  • Therapeutic options for 5-lipoxygenase inhibitors.

    Oliver Werz;Dieter Steinhilber

  • Boswellic acids: biological actions and molecular targets.

    Daniel Poeckel;Oliver Werz

  • 5-lipoxygenase: cellular biology and molecular pharmacology.

    Oliver Werz

  • 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.

    Oliver Werz;Jenny Klemm;Bengt Samuelsson;Olof Rådmark

  • Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

    Oliver Werz;Oliver Werz;Jana Gerstmeier;Stephania Libreros;Xavier De la Rosa

  • Multi-target approach for natural products in inflammation.

    Andreas Koeberle;Oliver Werz

  • Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

    Oliver Werz;Eva Bürkert;Bengt Samuelsson;Olof Rådmark

  • ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma

    Carlo Pergola;Gabriele Dodt;Antonietta Rossi;Eva Neunhoeffer

  • Structure-Based Discovery of Inhibitors of Microsomal Prostaglandin E2 Synthase−1, 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein: Promising Hits for the Development of New Anti-inflammatory Agents

    Rosa De Simone;Maria Giovanna Chini;Ines Bruno;Raffaele Riccio

  • 5-Lipoxygenase inhibitors: a review of recent developments and patents

    Carlo Pergola;Oliver Werz

  • Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

    Andreas Koeberle;Ulf Siemoneit;Ulrike Bühring;Hinnak Northoff

  • Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin.

    Oliver Werz

  • Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes

    Oliver Werz;Eva Bürkert;Lutz Fischer;Dagmar Szellas

  • Development of 5-lipoxygenase inhibitors--lessons from cellular enzyme regulation.

    Oliver Werz;Dieter Steinhilber

  • Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes.

    Daniel Poeckel;Christine Greiner;Moritz Verhoff;Oliver Rau

Frequent Co-Authors

Olof Rådmark
Olof Rådmark Karolinska Institute
Bengt Samuelsson
Bengt Samuelsson Karolinska Institute
Lidia Sautebin
Lidia Sautebin University of Naples Federico II
Stefan Laufer
Stefan Laufer University of Tübingen
Daniela Schuster
Daniela Schuster Paracelsus Medical University
Hermann Stuppner
Hermann Stuppner University of Innsbruck
Gerhard Wolber
Gerhard Wolber Freie Universität Berlin
Jindrich Cinatl
Jindrich Cinatl Goethe University Frankfurt
Karl-Dieter Entian
Karl-Dieter Entian Goethe University Frankfurt

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