World's Best Scientists 2026 revealed!
Andrew C. Chan

Andrew C. Chan

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
24125
World Ranking
9459
National Ranking
4173

Overview

Andrew C. Chan is affiliated with Genentech in the United States and has a research profile encompassing multiple fields within biomedical science. Their work spans Medicine and Biochemistry, Genetics and Molecular Biology, with a notable focus on Pediatrics, Perinatology and Child Health, Immunology, Molecular Biology, Oncology, and Genetics.

The scientist's main research topics include Prenatal Screening and Diagnostics, Protein Tyrosine Phosphatases, T-cell and B-cell Immunology, Fetal and Pediatric Neurological Disorders, Renal and related cancers, Monoclonal and Polyclonal Antibodies Research, and CAR-T cell therapy research.

Andrew C. Chan has contributed to several recent publications, including:

  • "Fifty years of monoclonals: the past, present and future of antibody therapeutics" (2025) in Nature reviews. Immunology
  • "Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study" (2023) in The Lancet
  • "B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation" (2022) in Cell Reports
  • "Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy" (2020) in Journal for ImmunoTherapy of Cancer
  • "30 Years of Biotherapeutics Development-What Have We Learned?" (2020) in Annual Review of Immunology

The scientist frequently publishes in journals such as Obstetrical & Gynecological Survey, Nature reviews. Immunology, The Lancet, Journal for ImmunoTherapy of Cancer, and Annual Review of Immunology.

Collaborative work includes frequent coauthors:

  • Eva R. Hoffmann
  • Tanja Schlaikjær Hartwig
  • Jennifer R. Gruhn
  • Henriette Svarre Nielsen
  • Louise Ambye

Best Publications

  • Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

    Z. Songyang;A. S. Fanning;C. Fu;J. Xu

  • ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

    Andrew C. Chan;Makio Iwashima;Christoph W. Turck;Arthur Weiss

  • Therapeutic antibodies for autoimmunity and inflammation

    Andrew C. Chan;Paul J. Carter

  • Immunoglobulin variants and uses thereof

    Camellia W. Adams;Andrew C. Chan;Craig W. Crowley;Henry B. Lowman

  • Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

    M. Iwashima;B. A. Irving;N. S. C. Van Oers;A. C. Chan;A. C. Chan

  • T Cell Receptor Signaling Precedes Immunological Synapse Formation

    Kyeong-Hee Lee;Amy D. Holdorf;Michael L. Dustin;Andrew C. Chan

  • BLNK: a Central Linker Protein in B Cell Activation

    Chong Fu;Christoph W. Turck;Tomohiro Kurosaki;Andrew C. Chan

  • Activation of human CD4 + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

    Claudia Kemper;Andrew C Chan;Jonathan M Green;Kelly A Brett

  • Essential role for ZAP-70 in both positive and negative selection of thymocytes

    Izumi Negishi;Izumi Negishi;Izumi Negishi;Noboru Motoyama;Kei Ichi Nakayama;Kei Ichi Nakayama;Kei Ichi Nakayama;Keiko Nakayama;Keiko Nakayama;Keiko Nakayama

  • Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy.

    Qian Gong;Qinglin Ou;Shiming Ye;Wyne P. Lee

  • A biosynthetic pathway for anandamide

    Jie Liu;Lei Wang;Judith Harvey-White;Douglas Osei-Hyiaman

  • A specificity map for the PDZ domain family.

    Raffi Tonikian;Yingnan Zhang;Stephen L Sazinsky;Bridget Currell

  • Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

    David R. Plas;Robin Johnson;Jeanette T. Pingel;R. James Matthews

  • Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

    A C Chan;M Dalton;R Johnson;G H Kong

  • PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells.

    Kiminori Hasegawa;Flavius Martin;Guangming Huang;Dan Tumas

  • B CELL IMMUNOBIOLOGY IN DISEASE: Evolving Concepts from the Clinic

    Flavius Martin;Andrew C. Chan

  • Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

    Juliane Bubeck Wardenburg;Chong Fu;Janet K. Jackman;Horst Flotow

  • BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

    Masamichi Ishiai;Mari Kurosaki;Rajita Pappu;Katsuya Okawa

  • An essential role for BLNK in human B cell development.

    Yoshiyuki Minegishi;Jurg Rohrer;Elaine Coustan-Smith;Howard M. Lederman

  • Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

    A R Abbas;D Baldwin;Y Ma;W Ouyang

Frequent Co-Authors

Tomohiro Kurosaki
Tomohiro Kurosaki Osaka University
Nunzio Bottini
Nunzio Bottini University of California, San Diego
Masamichi Ishiai
Masamichi Ishiai Kyoto University
Gerhard Rogler
Gerhard Rogler University of Zurich
Michael L. Dustin
Michael L. Dustin University of Oxford
Gabriel Waksman
Gabriel Waksman University College London
Arthur Weiss
Arthur Weiss University of California, San Francisco

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring an education in Biology or Biochemistry can open doors to a broad range of dynamic careers in healthcare, research, and nutrition. For those seeking flexible study options, many reputable universities now offer comprehensive online pathways tailored to students' unique needs and schedules.

Students interested in quickly entering the healthcare workforce might consider a ma to lpn program. This pathway helps medical assistants advance their careers by becoming licensed practical nurses through online coursework and clinical training.

For those passionate about the sciences, a bs in biology online can provide a strong foundation for further studies or entry into laboratory, research, and pharmaceutical careers. Similarly, aspiring nurses can take advantage of registered nurse online programs to earn licensure and join one of the most in-demand professions in the US.

Nutrition and health enthusiasts may pursue programs like the best online registered dietitian programs, offering a flexible route toward becoming a credentialed nutrition expert.

Each of these programs combines robust curriculum, accredited faculty, and the convenience of online learning—enabling you to advance your education and career from anywhere in the world.

Best Scientists Citing Andrew C. Chan

Trending Scientists

Recently Published Articles