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Neuroscience

D-Index
35
Citations
9896
World Ranking
9099
National Ranking
442

Overview

Clément Léna is affiliated with the École Normale Supérieure in France and primarily conducts research in the broad field of neuroscience. Their work spans several subfields including neurology, cellular and molecular neuroscience, cognitive neuroscience, endocrine and autonomic systems, and sensory systems.

The main topics covered in their research include:

  • Neuroscience and neuropharmacology research
  • Vestibular and auditory disorders
  • Neuroinflammation and neurodegeneration mechanisms
  • Neural dynamics and brain function
  • Memory and neural mechanisms
  • Sleep and wakefulness research
  • Neurological disorders and treatments

Léna has contributed to several research publications. Notable recent papers include:

  • "Bidirectional control of fear memories by cerebellar neurons projecting to the ventrolateral periaqueductal grey," 2020, published in Nature Communications
  • "Cerebellar control of fear learning via the cerebellar nuclei-Multiple pathways, multiple mechanisms?", 2023, published in Frontiers in Systems Neuroscience
  • "The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice," 2023, published in Nature Communications
  • "Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia," 2022, published in eLife
  • "Cerebellar stimulation prevents Levodopa-induced dyskinesia in mice and normalizes activity in a motor network," 2022, published in Nature Communications

The researcher frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Frontiers in Systems Neuroscience, European Neuropsychopharmacology, and eLife.

Frequent collaborators in their work include Daniela Popa, Romain W Sala, Jimena Laura Frontera, Caroline Mailhes-Hamon, and Hind Baba Aïssa.

Best Publications

  • Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

    Marina R. Picciotto;Marina R. Picciotto;Michele Zoli;Roberto Rimondini;Clément Léna

  • Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain.

    Marina R. Picciotto;Michele Zoli;Clement Léna;Alain Bessis

  • Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

    Lisa M. Marubio;Maria del Mar Arroyo-Jimenez;Matilde Cordero-Erausquin;Clément Léna

  • Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

    Nicolas Champtiaux;Cecilia Gotti;Matilde Cordero-Erausquin;Denis J. David

  • Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice

    Michele Zoli;Clément Léna;Marina R. Picciotto;Marina R. Picciotto;Jean-Pierre Changeux

  • Brain nicotinic receptors: structure and regulation, role in learning and reinforcement.

    Jean-Pierre Changeux;Daniel Bertrand;Pierre-Jean Corringer;Stanislas Dehaene

  • Coherent amygdalocortical theta promotes fear memory consolidation during paradoxical sleep

    Daniela Popa;Sevil Duvarci;Andrei T. Popescu;Clément Léna

  • Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus

    C Lena;JP Changeux;C Mulle

  • Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus.

    Clément Léna;Jean-Pierre Changeux

  • Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements

    Rémi D Proville;Rémi D Proville;Rémi D Proville;Maria Spolidoro;Maria Spolidoro;Maria Spolidoro;Nicolas Guyon;Nicolas Guyon;Nicolas Guyon;Guillaume P Dugué;Guillaume P Dugué;Guillaume P Dugué

  • Potentiation of nicotinic receptor response by external calcium in rat central neurons.

    Christophe Mulle;Clément Léna;Jean-Pierre Changeux

  • Allosteric modulations of the nicotinic acetylcholine receptor

    Clément Léna;Jean-Pierre Changeux

  • Electrical Coupling Mediates Tunable Low-Frequency Oscillations and Resonance in the Cerebellar Golgi Cell Network

    Guillaume P. Dugué;Nicolas Brunel;Vincent Hakim;Eric Schwartz

  • α‐synuclein assemblies sequester neuronal α3‐Na+/K+‐ATPase and impair Na+ gradient

    Amulya Nidhi Shrivastava;Virginie Redeker;Nicolas Fritz;Laura Pieri

  • Contribution of 5-HT2 Receptor Subtypes to Sleep–Wakefulness and Respiratory Control, and Functional Adaptations in Knock-Out Mice Lacking 5-HT2A Receptors

    Daniela Popa;Clément Léna;Véronique Fabre;Caroline Prenat

  • Lasting Syndrome of Depression Produced by Reduction in Serotonin Uptake During Postnatal Development: Evidence From Sleep, Stress, and Behavior

    Daniela Popa;Clément Léna;Chloé Alexandre;Chloé Alexandre;Joëlle Adrien;Joëlle Adrien;Joëlle Adrien

  • High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum.

    Camille de Solages;Germán Szapiro;Nicolas Brunel;Vincent Hakim

  • Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons.

    Clément Léna;Alban de Kerchove d’Exaerde;Matilde Cordero-Erausquin;Nicolas Le Novère

  • 2-Containing Nicotinic Receptors Contribute to the Organization of Sleep and Regulate Putative Micro-Arousals in Mice

    Clément Léna;Daniela Popa;Régis Grailhe;Pierre Escourrou

  • Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge

    Joseph Chaumont;Nicolas Guyon;Antoine M. Valera;Guillaume P. Dugué

  • Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders.

    Clément Léna;Jean-Pierre Changeux

Frequent Co-Authors

Jean-Pierre Changeux
Jean-Pierre Changeux Institut Pasteur
Marina R. Picciotto
Marina R. Picciotto Yale University
Michele Zoli
Michele Zoli University of Modena and Reggio Emilia
Stéphane Dieudonné
Stéphane Dieudonné École Normale Supérieure
Christophe Mulle
Christophe Mulle University of Bordeaux
Sonia Garel
Sonia Garel École Normale Supérieure
Nicolas Brunel
Nicolas Brunel Duke University
Emilio Merlo Pich
Emilio Merlo Pich GlaxoSmithKline (United Kingdom)
Kjell Fuxe
Kjell Fuxe Karolinska Institute
Roberto Rimondini
Roberto Rimondini University of Bologna

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