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Hidetoshi Tozaki-Saitoh

Hidetoshi Tozaki-Saitoh

D-Index & Metrics

Neuroscience

D-Index
45
Citations
7101
World Ranking
6954
National Ranking
233

Overview

Hidetoshi Tozaki-Saitoh is affiliated with Kyushu University in Japan and has an extensive publication record primarily in the fields of medicine and neuroscience. Their research focuses notably on pain mechanisms, neuroinflammation, ion channel regulation, and purinergic signaling.

The main fields of study covered by Tozaki-Saitoh include:

  • Medicine
  • Neuroscience

They have contributed to various subfields such as:

  • Physiology
  • Neurology
  • Immunology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Key research topics addressed by Tozaki-Saitoh encompass:

  • Pain Mechanisms and Treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Ion channel regulation and function
  • Adenosine and Purinergic Signaling
  • Immune Response and Inflammation
  • Exercise and Physiological Responses
  • Neuropeptides and Animal Physiology

The scientist has several recent publications with notable research findings, including:

  • "Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity," 2020, Nature Neuroscience
  • "A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior," 2021, Proceedings of the National Academy of Sciences
  • "Mechanical pain of the lower extremity after compression of the upper spinal cord involves signal transducer and activator of transcription 3-dependent reactive astrocytes and interleukin-6," 2020, Brain Behavior and Immunity
  • "The Role of Microglial Purinergic Receptors in Pain Signaling," 2022, Molecules
  • "Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors," 2020, Journal of Pharmacological Sciences

Frequent co-authors who have collaborated with Tozaki-Saitoh include:

  • Makoto Tsuda
  • K. Koga
  • Ryoichi Tashima
  • Kazuhide Inoue
  • Sachi Shimizu

The scientist's work has been published in venues such as:

  • Proceedings for Annual Meeting of The Japanese Pharmacological Society
  • Cells
  • Preprints.org
  • Nature Neuroscience
  • Proceedings of the National Academy of Sciences

Best Publications

  • IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

    Takahiro Masuda;Makoto Tsuda;Ryohei Yoshinaga;Hidetoshi Tozaki-Saitoh

  • JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

    Makoto Tsuda;Yuta Kohro;Takayuki Yano;Tomoko Tsujikawa

  • P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

    Hidetoshi Tozaki-Saitoh;Makoto Tsuda;Hiroyuki Miyata;Kazuaki Ueda

  • IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain

    Makoto Tsuda;Takahiro Masuda;Junko Kitano;Hiroshi Shimoyama

  • STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

    Miho Shiratori-Hayashi;Keisuke Koga;Hidetoshi Tozaki-Saitoh;Yuta Kohro

  • Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain.

    Takahiro Masuda;Shosuke Iwamoto;Ryohei Yoshinaga;Hidetoshi Tozaki-Saitoh

  • Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays

    Makoto Tsuda;Kazuya Kuboyama;Tomoyuki Inoue;Kenichiro Nagata

  • P2Y6 receptor-Gα12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis

    Motohiro Nishida;Yoji Sato;Aya Uemura;Yusuke Narita

  • Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

    Tao Chen;Wataru Taniguchi;Qi Yu Chen;Hidetoshi Tozaki-Saitoh

  • Activation of dorsal horn microglia contributes to diabetes‐induced tactile allodynia via extracellular signal‐regulated protein kinase signaling

    Makoto Tsuda;Hikaru Ueno;Ayako Kataoka;Hidetoshi Tozaki-Saitoh

  • P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways.

    Miho Shiratori;Hidetoshi Tozaki-Saitoh;Mai Yoshitake;Makoto Tsuda

  • Neuronal CCL21 up‐regulates microglia P2X4 expression and initiates neuropathic pain development

    Knut Biber;Knut Biber;Makoto Tsuda;Hidetoshi Tozaki-Saitoh;Keiko Tsukamoto

  • Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

    Takahiro Masuda;Yui Ozono;Satsuki Mikuriya;Yuta Kohro

  • The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

    Yoshinori Hayashi;Satoru Koyanagi;Naoki Kusunose;Ryo Okada

  • Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief

    Kenichiro Nagata;Toshiyasu Imai;Tomohiro Yamashita;Makoto Tsuda

  • Pain and purinergic signaling

    Makoto Tsuda;Hidetoshi Tozaki-Saitoh;Kazuhide Inoue

  • P2X4 receptors and neuropathic pain

    Makoto Tsuda;Takahiro Masuda;Hidetoshi Tozaki-Saitoh;Kazuhide Inoue

  • P2Y1 receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL‐6 release in hippocampal cultures

    Takumi Fujita;Hidetoshi Tozaki-Saitoh;Kazuhide Inoue

  • Microglial regulation of neuropathic pain.

    Makoto Tsuda;Takahiro Masuda;Hidetoshi Tozaki-Saitoh;Kazuhide Inoue

  • A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

    Yuta Matsumura;Tomohiro Yamashita;Atsushi Sasaki;Eriko Nakata

  • Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT

    Ayako Kataoka;Hidetoshi Tozaki-Saitoh;Yui Koga;Makoto Tsuda

Frequent Co-Authors

Makoto Tsuda
Makoto Tsuda Kyushu University
Kazuhide Inoue
Kazuhide Inoue Kyushu University
Hidemasa Furue
Hidemasa Furue Hyogo College of Medicine
Shinichi Kohsaka
Shinichi Kohsaka Keio University
Min Zhuo
Min Zhuo University of Toronto
Michael W. Salter
Michael W. Salter University of Toronto
Nobuyuki Yanagihara
Nobuyuki Yanagihara University of Occupational and Environmental Health Japan
Kazue Mizumura
Kazue Mizumura Nihon University
Hiroshi Nakanishi
Hiroshi Nakanishi Yasuda Women's University
Keiko Ozato
Keiko Ozato Eunice Kennedy Shriver National Institute of Child Health and Human Development

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