World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
35381
World Ranking
3995
National Ranking
1973

Overview

Kevin R. Coombes is affiliated with The Ohio State University in the United States. Their research spans several fields with a focus on biochemistry, genetics, molecular biology, and medicine. Within these areas, they have contributed extensively to molecular biology, cancer research, genetics, artificial intelligence, and hematology.

The scientist's work centers on topics such as gene expression and cancer classification, cancer genomics and diagnostics, acute myeloid leukemia research, chronic lymphocytic leukemia research, RNA modifications and cancer, cancer-related molecular mechanisms research, and molecular biology techniques and applications.

Recent publications include:

  • Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration, 2023, Cancer Discovery
  • Diverse tumorigenic consequences of human papillomavirus integration in primary oropharyngeal cancers, 2021, Genome Research
  • DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia, 2021, Genome Research
  • Unsupervised machine learning and prognostic factors of survival in chronic lymphocytic leukemia, 2020, Journal of the American Medical Informatics Association
  • Simulation-derived best practices for clustering clinical data, 2021, Journal of Biomedical Informatics

Kevin R. Coombes frequently collaborates with several researchers, including:

  • Zachary B. Abrams
  • Lynne V. Abruzzo
  • Caitlin E. Coombes
  • James S. Blachly
  • Amir Asiaee

The scientist has published multiple times in venues such as bioRxiv (Cold Spring Harbor Laboratory), Bioinformatics, F1000Research, Cancer Genetics, and Cancers. Their most frequent publication venue is bioRxiv, with 13 publications.

Best Publications

  • Comprehensive molecular portraits of human breast tumours

    Daniel C. Koboldt;Robert S. Fulton;Michael D. McLellan;Heather Schmidt

  • An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

    Lauren Averett Byers;Lixia Diao;Jing Wang;Pierre Saintigny

  • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

    Ramiro Garzon;Stefano Volinia;Stefano Volinia;Chang-Gong Liu;Cecilia Fernandez-Cymering

  • Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments

    Keith A. Baggerly;Jeffrey S. Morris;Kevin R. Coombes

  • Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

    Ferdinandos Skoulidis;Lauren A. Byers;Lixia Diao;Vassiliki A. Papadimitrakopoulou

  • Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

    Nathan T. Ihle;Lauren Averett Byers;Edward S. Kim;Pierre Saintigny

  • Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1

    Lauren Averett Byers;Jing Wang;Monique B. Nilsson;Junya Fujimoto

  • Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells.

    Michael Sun;Zeev Estrov;Yuan Ji;Kevin R. Coombes

  • Improved peak detection and quantification of mass spectrometry data acquired from surface-enhanced laser desorption and ionization by denoising spectra with the undecimated discrete wavelet transform

    Kevin R. Coombes;Spiridon Tsavachidis;Jeffrey Morris;Keith A Baggerly

  • A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition.

    Milena P. Mak;Milena P. Mak;Pan Tong;Lixia Diao;Robert J. Cardnell

  • Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

    Shuying Liu;Makiko Umezu-Goto;Mandi Murph;Yiling Lu

  • Feature extraction and quantification for mass spectrometry in biomedical applications using the mean spectrum

    Jeffrey S. Morris;Kevin R. Coombes;John Koomen;Keith A. Baggerly

  • Signal in noise: Evaluating reported reproducibility of serum proteomic tests for ovarian cancer

    Keith A. Baggerly;Jeffrey S. Morris;Sarah R. Edmonson;Kevin R. Coombes

  • Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology

    Keith A. Baggerly;Kevin R. Coombes

  • MicroRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival

    Simona Rossi;Masayoshi Shimizu;Elisa Barbarotto;Milena S. Nicoloso

  • Quality Control and Peak Finding for Proteomics Data Collected from Nipple Aspirate Fluid by Surface-Enhanced Laser Desorption and Ionization

    Kevin R. Coombes;Herbert A. Fritsche;Charlotte Clarke;Jeng Neng Chen

  • Functional proteomic profiling of AML predicts response and survival

    Steven M. Kornblau;Raoul Tibes;Yi Hua Qiu;Wenjing Chen

  • Non-parametric quantification of protein lysate arrays

    Jianhua Hu;Xuming He;Keith A. Baggerly;Kevin R. Coombes

  • A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers

    Bryan T. Hennessy;Yiling Lu;Ana Maria Gonzalez-Angulo;Mark S. Carey

  • Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery.

    John M. Koomen;Donghui Li;Lian Chun Xiao;Thomas C. Liu

Frequent Co-Authors

Steven M. Kornblau
Steven M. Kornblau The University of Texas MD Anderson Cancer Center
Jing Wang
Jing Wang The University of Texas MD Anderson Cancer Center
John V. Heymach
John V. Heymach The University of Texas MD Anderson Cancer Center
Keith A. Baggerly
Keith A. Baggerly The University of Texas MD Anderson Cancer Center
John D. Minna
John D. Minna The University of Texas Southwestern Medical Center
Michael Andreeff
Michael Andreeff The University of Texas MD Anderson Cancer Center
Ignacio I. Wistuba
Ignacio I. Wistuba The University of Texas MD Anderson Cancer Center
Lixia Diao
Lixia Diao The University of Texas MD Anderson Cancer Center
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Luc Girard
Luc Girard The University of Texas Southwestern Medical Center

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