Jacqueline F. Sinclair

Overview

Best Publications

• The use of human hepatocyte cultures to study the induction of cytochrome P-450.

  Vsevolod E. Kostrubsky;Vinod Ramachandran;Raman Venkataramanan;Kenneth Dorko

  202
  Citations

• Evaluation of Hepatotoxic Potential of Drugs by Inhibition of Bile-Acid Transport in Cultured Primary Human Hepatocytes and Intact Rats

  Vsevolod E. Kostrubsky;Stephen C. Strom;Janean Hanson;Ellen Urda

  183
  Citations

• Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription.

  Joshua W. Hamilton;William J. Bement;Peter R. Sinclair;Peter R. Sinclair;Peter R. Sinclair;Jacqueline F. Sinclair;Jacqueline F. Sinclair;Jacqueline F. Sinclair

  157
  Citations

• Ethanol and Isopentanol Increase CYP3A and CYP2E in Primary Cultures of Human Hepatocytes

  V.E. Kostrubsky;S.C. Strom;S.G. Wood;S.A. Wrighton

  145
  Citations

• Induction of Cytochrome P4503A by Taxol in Primary Cultures of Human Hepatocytes

  Vsevolod E. Kostrubsky;Lionel D. Lewis;Stephen C. Strom;Sheryl G. Wood

  105
  Citations

• Seizure management in acute hepatic porphyria Risks of valproate and clonazepam

  Herbert L. Bonkowsky;Peter R. Sinclair;Scott Emery;Jacqueline F. Sinclair

  102
  Citations

• The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures.

  Vsevolod E. Kostrubsky;Jacqueline F. Sinclair;Vinod Ramachandran;Raman Venkataramanan

  101
  Citations

• Alcohol use and HIV pharmacotherapy.

  Thomas F. Kresina;Charles W. Flexner;Jacqueline Sinclair;Maria Almira Correia

  99
  Citations

• Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity

  Herbert C. Yohe;Kimberley A. O'Hara;Jane A. Hunt;Tamar J. Kitzmiller

  97
  Citations

• Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes.

  Seva E. Kostrubsky;Jacqueline F. Sinclair;Stephen C. Strom;Sheryl Wood

  94
  Citations

• Hormonal requirements for the induction of cytochrome P450 in hepatocytes cultured in a serum-free medium

  J.F. Sinclair;P.R. Sinclair;H.L. Bonkowsky

  94
  Citations

• High-performance liquid chromatographic separation and quantitation of tetrapyrroles from biological materials.

  Herbert L. Bonkovsky;Herbert L. Bonkovsky;Sheryl G. Wood;Scott K. Howell;Peter R. Sinclair;Peter R. Sinclair

  93
  Citations

• Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450: essential role of cytochrome P-450d

  J M Jacobs;P R Sinclair;P R Sinclair;W J Bement;R W Lambrecht

  91
  Citations

• Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2

  Richard W. Lambrecht;Peter R. Sinclair;Peter R. Sinclair;Nadia Gorman;Jacqueline F. Sinclair;Jacqueline F. Sinclair

  88
  Citations

• Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: Comparison of wild-type and Cyp2e1(-/-) mice

  Kristina K. Wolf;Sheryl G. Wood;Jenna L. Allard;Jane A. Hunt

  86
  Citations

• Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes

  Jacqueline F. Sinclair;Jacqueline F. Sinclair;Jennifer McCaffrey;Peter R. Sinclair;Peter R. Sinclair;William J. Bement

  86
  Citations

• Formation of cobalt protoporphyrin in the liver of rats. A mechanism for the inhibition of liver haem biosynthesis by inorganic cobalt.

  P Sinclair;A H Gibbs;J F Sinclair;F de Matteis

  85
  Citations

• Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4.

  Barbara W. LeDuc;Peter R. Sinclair;Louis Shuster;Jacqueline F. Sinclair

  83
  Citations

• Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes.

  Peter R. Sinclair;William J. Bement;Sally A. Haugen;Jacqueline F. Sinclair

  80
  Citations

• CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.

  Peter R. Sinclair;Nadia Gorman;Nadia Gorman;Heidi S. Walton;Heidi S. Walton;William J. Bement

  79
  Citations