World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
74
Citations
16260
World Ranking
4818
National Ranking
109

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Metabolism

Biochemistry, Glutathione, Enzyme, Stereochemistry and Glutathione reductase are his primary areas of study. As part of his studies on Biochemistry, P.J. van Bladeren often connects relevant areas like Vicinal. He combines subjects such as Cysteine and Biotransformation with his study of Glutathione.

His Enzyme assay study, which is part of a larger body of work in Enzyme, is frequently linked to Citral, bridging the gap between disciplines. His Stereochemistry study combines topics from a wide range of disciplines, such as Luteolin, Quercetin and Adduct. His Microsome research focuses on In vivo and how it connects with 1,2-Dibromoethane.

His most cited work include:

  • Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment (398 citations)
  • Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. (305 citations)
  • The interplay of glutathione-related processes in antioxidant defense (243 citations)

What are the main themes of his work throughout his whole career to date?

P.J. van Bladeren mostly deals with Biochemistry, Glutathione, Stereochemistry, Metabolism and Microsome. In most of his Biochemistry studies, his work intersects topics such as Toxicity. His research in Glutathione intersects with topics in Cysteine and Biotransformation.

His biological study spans a wide range of topics, including Mercapturic acid, Active site, Epoxide hydrolase and Stereoselectivity. The various areas that P.J. van Bladeren examines in his Metabolism study include Chromatography and Excretion. His research integrates issues of Metabolite, Phenobarbital and Cytosol in his study of Microsome.

He most often published in these fields:

  • Biochemistry (59.12%)
  • Glutathione (59.12%)
  • Stereochemistry (23.27%)

What were the highlights of his more recent work (between 1995-2011)?

  • Biochemistry (59.12%)
  • Glutathione (59.12%)
  • Metabolism (20.13%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Biochemistry, Glutathione, Metabolism, Carcinogen and Pharmacology. P.J. van Bladeren merges Biochemistry with Ascorbic acid in his study. His studies deal with areas such as Stereochemistry and Biotransformation as well as Glutathione.

His study looks at the intersection of Metabolism and topics like Excretion with Glucuronide, Urine and tert-Butylhydroquinone. His Carcinogen research incorporates elements of Anticarcinogen, Toxicokinetics and Physiologically based pharmacokinetic modelling. His studies in Pharmacology integrate themes in fields like Toxicity, In vivo and Hesperetin.

Between 1995 and 2011, his most popular works were:

  • Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. (305 citations)
  • The interplay of glutathione-related processes in antioxidant defense (243 citations)
  • Toxicological evaluation and risk assessment of chemical mixtures (202 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Metabolism
  • Organic chemistry

His scientific interests lie mostly in Biochemistry, Glutathione, Cytochrome P450, Carcinogen and Metabolism. His Biochemistry research is multidisciplinary, incorporating perspectives in Safrole and Stereochemistry. He interconnects Enzyme assay and Antioxidant in the investigation of issues within Glutathione.

The Carcinogen study which covers Biotransformation that intersects with Phenobarbital, Anticarcinogen and Detoxification. The Metabolism study combines topics in areas such as Deoxyguanosine and Physiologically based pharmacokinetic modelling. The concepts of his Microsome study are interwoven with issues in Isozyme and In vivo.

Best Publications

  • Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment

    V J Feron;H P Til;F de Vrijer;R A Woutersen

  • A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model

    Francois-Pierre J. Martin;Francois-Pierre J. Martin;Marc-Emmanuel Dumas;Yulan Wang;Cristina Legido-Quigley

  • Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model

    Francois-Pierre J. Martin;Francois-Pierre J. Martin;Yulan Wang;Norbert Sprenger;Ivan K S Yap

  • The interplay of glutathione-related processes in antioxidant defense

    N.H.P. Cnubben;I.M.C.M. Rietjens;H. Wortelboer;J.J. van Zanden

  • Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man.

    J. J. P. Bogaards;M. Bertrand;P. Jackson;M. J. Oudshoorn

  • Colonization-Induced Host-Gut Microbial Metabolic Interaction

    Sandrine P. Claus;Sandrine L. Ellero;Bernard Berger;Lutz Krause

  • Toxicological evaluation and risk assessment of chemical mixtures

    F.R. Cassee;J.P. Groten;P.J. van Bladeren;V.J. Feron

  • Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases.

    Marelle G Boersma;Hester van der Woude;Jan Bogaards;Sjef Boeren

  • Glutathione S-transferases in relation to their role in the biotransformation of xenobiotics.

    R.M.E. Vos;P.J. van Bladeren

  • Reduction of oxidative DNA-damage in humans by Brussels sprouts

    H. Verhagen;H.E. Poulsen;S. Loft;G. van Poppel

  • Involvement of Human Glutathione S-Transferase Isoenzymes in the Conjugation of Cyclophosphamide Metabolites with Glutathione

    H.A.A.M. Dirven;B. van Ommen;P.J. van Bladeren

  • The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane

    P.J. van Bladeren;D.D. Breimer;G.M.T. Rotteveel-Smijs;R.A.W. De Jong

  • Human Metabolic Phenotypes Link Directly to Specific Dietary Preferences in Healthy Individuals

    Serge Rezzi;Ziad Ramadan;François-Pierre J Martin;Laurent B Fay

  • Structure-activity study on the quinone/quinone methide chemistry of flavonoids.

    H.M. Awad;M.G. Boersma;S. Boeren;P.J. van Bladeren

  • Consumption of Brussels sprouts results in elevated alpha-class glutathione S-transferase levels in human blood plasma.

    J.J.P. Boogaards;H. Verhagen;M.I. Willems;G. van Poppel

  • Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients.

    Walter Brand;Maaike E. Schutte;Gary Williamson;Jelmer J. van Zanden

  • Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers.

    Walter Brand;Petronella A. I. van der Wel;Maarit J. Rein;Denis Barron

  • Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.

    Jelmer J van Zanden;Liesbeth Geraets;Heleen M Wortelboer;Peter J.van Bladeren;Peter J.van Bladeren

  • Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate.

    I.M. Bruggeman;J.H.M. Temmink;P.J. van Bladeren

  • Inhibition of glutathione S-transferase activity in human melanoma cells by α,β-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal

    M.L.P.S. van Iersel;J.P.H.T.M. Ploemen;I. Struik;C. van Amersfoort

Frequent Co-Authors

Ivonne M.C.M. Rietjens
Ivonne M.C.M. Rietjens Wageningen University & Research
Douwe D. Breimer
Douwe D. Breimer Leiden University
Nico P. E. Vermeulen
Nico P. E. Vermeulen Vrije Universiteit Amsterdam
Jan N. M. Commandeur
Jan N. M. Commandeur Vrije Universiteit Amsterdam
Flemming R. Cassee
Flemming R. Cassee Utrecht University
J. van der Greef
J. van der Greef Leiden University
Abraham Brouwer
Abraham Brouwer Vrije Universiteit Amsterdam
Paul E. Thomas
Paul E. Thomas Rutgers, The State University of New Jersey
John D. Hayes
John D. Hayes University of Dundee
Philippe Beaune
Philippe Beaune Université Paris Cité

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