World's Best Scientists 2026 revealed!
Jochen Reinstein

Jochen Reinstein

D-Index & Metrics

Chemistry

D-Index
56
Citations
10328
World Ranking
11719
National Ranking
863

Biology and Biochemistry

D-Index
56
Citations
10265
World Ranking
14525
National Ranking
1036

Overview

Jochen Reinstein is affiliated with the Max Planck Society in Germany and is active in the field of biochemistry, genetics, and molecular biology. Their research spans multiple subfields, including molecular biology, cell biology, organic chemistry, materials chemistry, and radiology, nuclear medicine, and imaging.

Their recent publications focus on protein tag characterization, ultrafast pump-probe experiments, chemical exchange saturation transfer NMR, and enzyme specificity. Selected papers include:

  • Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag (2021), published in Biochemistry
  • Illumination guidelines for ultrafast pump-probe experiments by serial femtosecond crystallography (2020), published in Nature Methods
  • Multiquantum Chemical Exchange Saturation Transfer NMR to Quantify Symmetrical Exchange: Application to Rotational Dynamics of the Guanidinium Group in Arginine Side Chains (2020), published in The Journal of Physical Chemistry Letters
  • Engineered Nonribosomal Peptide Synthetase Shows Opposite Amino Acid Loading and Condensation Specificity (2021), published in ACS Catalysis
  • Kinetic and structural characterization of the self-labeling protein tags HaloTag7, SNAP-tag and CLIP-tag (2021), published in bioRxiv (Cold Spring Harbor Laboratory)

The main topics of their work cover:

  • Biotin and Related Studies
  • Click Chemistry and Applications
  • Monoclonal and Polyclonal Antibodies Research
  • Photosynthetic Processes and Mechanisms
  • Enzyme Structure and Function
  • Advanced Electron Microscopy Techniques and Applications
  • Advanced X-ray Imaging Techniques

Reinstein frequently collaborates with other researchers including Mirosław Tarnawski, Jonas Wilhelm, Stefanie Kühn, Julien Hiblot, and Kai Johnsson.

Key publication venues featured in Reinstein's body of work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochemistry
  • Nature Methods
  • ACS Catalysis
  • Nature Chemical Biology

The diversity in Reinstein's research encompasses significant areas of molecular and cellular biology, utilizing advanced chemical and imaging techniques. This interdisciplinary approach reflects a scientific focus on molecular mechanisms and biochemical processes, with applications ranging from enzyme characterization to imaging methods in life sciences.

Best Publications

  • Mechanism of regulation of Hsp70 chaperones by DnaJ cochaperones

    Thomas Laufen;Matthias P. Mayer;Christian Beisel;Dagmar Klostermeier

  • The role of ATP in the functional cycle of the DnaK chaperone system

    John S. McCarty;Alexander Buchberger;Alexander Buchberger;Jochen Reinstein;Bernd Bukau;Bernd Bukau

  • Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding

    C. W. Müller;G. J. Schlauderer;Jochen Reinstein;Georg E. Schulz

  • Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation.

    Thomas R. M. Barends;Lutz Foucar;Albert Ardevol;Karol Nass

  • Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase.

    Thomas R. M. Barends;Elisabeth Hartmann;Julia J. Griese;Thorsten Beitlich

  • Nucleotide-induced Conformational Changes in the ATPase and Substrate Binding Domains of the DnaK Chaperone Provide Evidence for Interdomain Communication

    Alexander Buchberger;Holger Theyssen;Hartwig Schröder;John S. McCarty

  • Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange.

    Dirk Brehmer;Stefan Rüdiger;Claudia S. Gässler;Dagmar Klostermeier;Dagmar Klostermeier

  • Sti1 is a non-competitive inhibitor of the Hsp90 ATPase - Binding prevents the N-terminal dimerization reaction during the ATPase cycle

    Klaus Richter;Paul Muschler;Otmar Hainzl;Jochen Reinstein

  • GrpE Accelerates Nucleotide Exchange of the Molecular Chaperone DnaK with an Associative Displacement Mechanism

    Lars Packschies;Holger Theyssen;Alexander Buchberger;Bernd Bukau

  • Crystal structures of the AppA BLUF domain photoreceptor provide insights into blue light-mediated signal transduction.

    Astrid Jung;Jochen Reinstein;Tatiana Domratcheva;Robert L. Shoeman

  • Substrate transfer from the chaperone Hsp70 to Hsp90.

    Harald Wegele;Sebastian K. Wandinger;Andreas B. Schmid;Jochen Reinstein

  • Sti1 is a novel activator of the Ssa proteins.

    Harald Wegele;Martin Haslbeck;Jochen Reinstein;Johannes Buchner

  • The bottleneck in AZT activation

    Arnon Lavie;Ilme Schlichting;Ingrid R. Vetter;Manfred Konrad

  • Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin.

    Gabriela Nass Kovacs;Jacques-Philippe Colletier;Marie Luise Grünbein;Yang Yang

  • Conserved conformational changes in the ATPase cycle of human Hsp90

    Klaus Richter;Joanna Soroka;Lukasz Skalniak;Adriane Leskovar

  • C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle.

    Tina Weikl;Paul Muschler;Klaus Richter;Thomas Veit

  • Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

    Jing Li;Klaus Richter;Jochen Reinstein;Johannes Buchner

  • Kinetic and structural characterization of the self-labeling protein tags HaloTag7, SNAP-tag and CLIP-tag

    Jonas Wilhelm;Stefanie Kühn;Miroslaw Tarnawski;Guillaume Gotthard

  • MUTATIONS IN THE NUCLEOTIDE BINDING LOOP OF ADENYLATE KINASE OF ESCHERICHIA-COLI

    Jochen Reinstein;Martin Brune;Alfred Wittinghofer

  • The ATPase cycle of the endoplasmic chaperone Grp94.

    Stephan Frey;Adriane Leskovar;Jochen Reinstein;Johannes Buchner

  • Coupling and dynamics of subunits in the hexameric AAA+ chaperone ClpB.

    Nicolas D. Werbeck;Sandra Schlee;Jochen Reinstein

Frequent Co-Authors

Ilme Schlichting
Ilme Schlichting Max Planck Society
Joachim Heberle
Joachim Heberle Freie Universität Berlin
Roger S. Goody
Roger S. Goody Max Planck Society
Johannes Buchner
Johannes Buchner Technical University of Munich
Alfred Wittinghofer
Alfred Wittinghofer Max Planck Society
Bernd Bukau
Bernd Bukau Heidelberg University
Ingrid R. Vetter
Ingrid R. Vetter Max Planck Society
Klaus Scheffzek
Klaus Scheffzek Innsbruck Medical University
Jan Balzarini
Jan Balzarini KU Leuven
Thomas Scheibel
Thomas Scheibel University of Bayreuth

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