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Giovanna Lucchini

Giovanna Lucchini

D-Index & Metrics

Molecular Biology

D-Index
65
Citations
14007
World Ranking
1675
National Ranking
35

Overview

Giovanna Lucchini is affiliated with the University of Milan in Italy and has published extensively in the field of medicine, with a particular focus on hematology and related subfields. Their work includes research on genetics, oncology, immunology, and public health as related to hematopoietic treatments and cellular therapies.

Their research covers key topics such as:

  • CAR-T cell therapy research
  • Hematopoietic Stem Cell Transplantation
  • Virus-based gene therapy research
  • Acute Lymphoblastic Leukemia research
  • Immunodeficiency and Autoimmune Disorders
  • Childhood Cancer Survivors' Quality of Life
  • Cytomegalovirus and herpesvirus research

Lucchini has contributed regularly to several publication venues, with multiple papers appearing in:

  • Blood (10 papers)
  • Bone Marrow Transplantation (9 papers)
  • Blood Advances (4 papers)
  • Transplantation and Cellular Therapy (4 papers)
  • British Journal of Haematology (3 papers)

Notable recent papers include:

  • "Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies," 2020, The Lancet
  • "CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial," 2021, Nature Medicine
  • "Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia," 2022, Science Translational Medicine
  • "Hematopoietic cell transplantation in chronic granulomatous disease: a study of 712 children and adults," 2020, Blood
  • "CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL," 2023, Blood

Frequent co-authors include:

  • Persis Amrolia (22 joint publications)
  • Kanchan Rao (21 joint publications)
  • Robert Chiesa (21 joint publications)
  • Adriana Balduzzi (17 joint publications)
  • Ajay Vora (14 joint publications)

Lucchini's main field of study is medicine, where they have authored over 100 publications. Within medicine, their focused areas include genetics, hematology, and oncology, reflecting a strong engagement with research in blood disorders and immune system therapies.

Best Publications

  • The complete DNA sequence of yeast chromosome III.

    S. G. Oliver;Q. J. M. van der Aart;M. L. Agostoni-Carbone;M. Aigle

  • Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

    Waseem Qasim;Hong Zhan;Sujith Samarasinghe;Stuart Adams

  • Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR.

    Sara Ghorashian;Anne Marijn Kramer;Shimobi Onuoha;Gary Wright

  • Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study

    Andrea Biondi;Martin Schrappe;Paola De Lorenzo;Anders Castor

  • The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication.

    Marco Foiani;Federica Marini;Daniela Gamba;Giovanna Lucchini

  • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

    Vera Paciotti;Michela Clerici;Giovanna Lucchini;Maria Pia Longhese

  • Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies.

    Reuben Benjamin;Reuben Benjamin;Charlotte Graham;Charlotte Graham;Deborah Yallop;Agnieszka Jozwik;Agnieszka Jozwik

  • A short nucleotide sequence required for regulation of HIS4 by the general control system of yeast

    Thomas F. Donahue;Robert S. Daves;Giovanna Lucchini;Gerald R. Fink

  • Treatment of graft versus host disease with mesenchymal stromal cells: a phase I study on 40 adult and pediatric patients.

    Martino Introna;Giovanna Lucchini;Erica Dander;Stefania Galimberti

  • CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial.

    Shaun Cordoba;Shimobi Onuoha;Simon Thomas;Daniela Soriano Pignataro

  • Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores.

    Roberta Fraschini;Alessia Beretta;Lucia Sironi;Andrea Musacchio

  • The Saccharomyces cerevisiae Sae2 Protein Promotes Resection and Bridging of Double Strand Break Ends

    Michela Clerici;Davide Mantiero;Giovanna Lucchini;Maria Pia Longhese

  • Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population.

    Giovanna Lucchini;Martino Introna;Erica Dander;Attilio Rovelli

  • Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae.

    G Lucchini;A G Hinnebusch;C Chen;G R Fink

  • Budding Yeast Bub2 Is Localized at Spindle Pole Bodies and Activates the Mitotic Checkpoint via a Different Pathway from Mad2

    Roberta Fraschini;Elisa Formenti;Giovanna Lucchini;Simonetta Piatti

  • DNA damage checkpoint in budding yeast.

    Maria Pia Longhese;Marco Foiani;Marco Muzi‐Falconi;Giovanna Lucchini

  • The Yku70–Yku80 complex contributes to regulate double‐strand break processing and checkpoint activation during the cell cycle

    Michela Clerici;Davide Mantiero;Ilaria Guerini;Giovanna Lucchini

  • DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases.

    Antonella Pizzagalli;Paola Valsasnini;Paolo Plevani;Giovanna Lucchini

  • The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling.

    Michela Clerici;Davide Mantiero;Giovanna Lucchini;Maria Pia Longhese

  • Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p

    Vera Paciotti;Giovanna Lucchini;Paolo Plevani;Maria Pia Longhese

Frequent Co-Authors

Maria Pia Longhese
Maria Pia Longhese University of Milano-Bicocca
Paolo Plevani
Paolo Plevani University of Milan
Andrea Biondi
Andrea Biondi University of Milano-Bicocca
Marco Foiani
Marco Foiani University of Milan
Alessandro Rambaldi
Alessandro Rambaldi University of Milan
Martino Introna
Martino Introna Mario Negri Institute for Pharmacological Research
Maria Grazia Valsecchi
Maria Grazia Valsecchi University of Milano-Bicocca
Josée Golay
Josée Golay Mario Negri Institute for Pharmacological Research
Martin Schrappe
Martin Schrappe Kiel University
Antonello Villa
Antonello Villa University of Milano-Bicocca

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