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Immunology

D-Index
82
Citations
21821
World Ranking
1522
National Ranking
61

Overview

Martino Introna is affiliated with the Mario Negri Institute for Pharmacological Research in Italy. Their research spans multiple fields with a strong focus on Medicine and Biochemistry, Genetics, and Molecular Biology. The primary areas of study include Oncology, Genetics, Molecular Biology, Immunology, and Surgery.

Their work covers a variety of scientific topics such as:

  • CAR-T cell therapy research
  • Virus-based gene therapy research
  • Mesenchymal stem cell research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Immune Cell Function and Interaction
  • RNA Interference and Gene Delivery
  • Pancreatic function and diabetes

Martino Introna has published extensively, with frequent appearances in high-impact venues including Blood, Journal of the American Society of Nephrology, Frontiers in Immunology, Cytotherapy, and Blood Cancer Journal. Notable recent papers include:

  • Sleeping Beauty-engineered CAR T cells achieve antileukemic activity without severe toxicities (2020), Journal of Clinical Investigation
  • Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial (2021), The Lancet Neurology
  • Safety and Preliminary Efficacy of Mesenchymal Stromal Cell (ORBCEL-M) Therapy in Diabetic Kidney Disease: A Randomized Clinical Trial (NEPHSTROM) (2023), Journal of the American Society of Nephrology
  • Targeting CD33 in Chemoresistant AML Patient-Derived Xenografts by CAR-CIK Cells Modified with an Improved SB Transposon System (2020), Molecular Therapy
  • Immunotherapy for HER2-Positive Breast Cancer: Clinical Evidence and Future Perspectives (2022), Cancers

Collaboration is a significant aspect of Introna's research, with frequent coauthors including Alessandro Rambaldi, Josée Golay, Chiara Capelli, Sarah Tettamanti, and Giuseppe Gaipa.

This combined expertise and scholarly output contribute important insights into immunotherapy, gene therapy, and stem cell-based treatments, highlighting the intersection of experimental and clinical research approaches within Introna's work.

Best Publications

  • Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis

    Josée Golay;Luisella Zaffaroni;Thomas Vaccari;Thomas Vaccari;Manuela Lazzari;Manuela Lazzari

  • Complement Activation Determines the Therapeutic Activity of Rituximab In Vivo

    Nicola Di Gaetano;Elena Cittera;Rachele Nota;Annunciata Vecchi

  • Cytokine regulation of endothelial cell function: from molecular level to the bedside

    Alberto Mantovani;Federico Bussolino;Martino Introna

  • CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59

    Josée Golay;Manuela Lazzari;Valeria Facchinetti;Sergio Bernasconi

  • PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans

    Giuseppe Peri;Martino Introna;Domenico Corradi;Giuseppe Iacuitti

  • Multimer Formation and Ligand Recognition by the Long Pentraxin PTX3 SIMILARITIES AND DIFFERENCES WITH THE SHORT PENTRAXINS C-REACTIVE PROTEIN AND SERUM AMYLOID P COMPONENT

    Barbara Bottazzi;Valérie Vouret-Craviari;Antonio Bastone;Luca De Gioia

  • Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program

    Marcello Chieppa;Giancarlo Bianchi;Andrea Doni;Annalisa Del Prete

  • Human Bone Marrow Mesenchymal Stem Cells Accelerate Recovery of Acute Renal Injury and Prolong Survival in Mice

    Marina Morigi;Martino Introna;Barbara Imberti;Daniela Corna

  • Transfer of growth factor receptor mRNA via exosomes unravels the regenerative effect of mesenchymal stem cells.

    Susanna Tomasoni;Lorena Longaretti;Cinzia Rota;Marina Morigi

  • The Cytolytically Inactive Terminal Complement Complex Activates Endothelial Cells to Express Adhesion Molecules and Tissue Factor Procoagulant Activity

    Francesco Tedesco;Mario Pausa;Ermanno Nardon;Martino Introna

  • Dual-functional capability of CD3 +CD56 + CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity

    Alice Pievani;Gianmaria Borleri;Daniela Pende;Lorenzo Moretta

  • Functional Properties of Human Vascular Endothelial Cadherin (7B4/Cadherin-5), an Endothelium-Specific Cadherin

    F. Breviario;L. Caveda;M. Corada;I. Martin-Padura

  • Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes

    Victor Vidai Alles;Barbara Bottazzi;Giuseppe Peri;Josée Golay

  • Autologous Mesenchymal Stromal Cells and Kidney Transplantation: A Pilot Study of Safety and Clinical Feasibility

    Norberto Perico;Federica Casiraghi;Martino Introna;Eliana Gotti

  • M2 macrophages phagocytose rituximab-opsonized leukemic targets more efficiently than m1 cells in vitro

    Marzia Leidi;Elisa Gotti;Luca Bologna;Elena Miranda

  • Mechanism of action of rituximab.

    Thomas Cerny;Bettina Borisch;Martino Introna;Peter Johnson

  • Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites

    M Introna;VV Alles;M Castellano;G Picardi

  • Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab.

    Josée Golay;Fabio Da Roit;Luca Bologna;Claudia Ferrara

  • Synergism between fludarabine and rituximab revealed in a follicular lymphoma cell line resistant to the cytotoxic activity of either drug alone

    N. Di Gaetano;Y. Xiao;E. Erba;R. Bassan

  • Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study

    Martino Introna;Gianmaria Borleri;Elena Conti;Marta Franceschetti

  • Treatment of graft versus host disease with mesenchymal stromal cells: a phase I study on 40 adult and pediatric patients.

    Martino Introna;Giovanna Lucchini;Erica Dander;Stefania Galimberti

  • Mechanism of Action of Type II, Glycoengineered, Anti-CD20 Monoclonal Antibody GA101 in B-Chronic Lymphocytic Leukemia Whole Blood Assays in Comparison with Rituximab and Alemtuzumab

    Luca Bologna;Elisa Gotti;Massimiliano Manganini;Alessandro Rambaldi

  • Cytokine regulation of endothelial cell function.

    M. Introna;F. Breviario;E. D'aniello;M. M. Luchetti

Frequent Co-Authors

Josée Golay
Josée Golay Mario Negri Institute for Pharmacological Research
Alessandro Rambaldi
Alessandro Rambaldi University of Milan
Alberto Mantovani
Alberto Mantovani Humanitas University
Andrea Biondi
Andrea Biondi University of Milano-Bicocca
Giuseppe Remuzzi
Giuseppe Remuzzi Mario Negri Institute for Pharmacological Research
Paola Allavena
Paola Allavena Humanitas University
Giuseppe Peri
Giuseppe Peri Mario Negri Institute for Pharmacological Research
Marta Muzio
Marta Muzio Vita-Salute San Raffaele University
Tiziano Barbui
Tiziano Barbui FROM-Fondazione per la Ricerca Ospedale di Bergamo
Nadia Polentarutti
Nadia Polentarutti Humanitas University

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