World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
50
Citations
11721
World Ranking
2548
National Ranking
1253

Overview

Y. Tony Ip is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a focus on cell biology, molecular biology, immunology, and related subfields. The scientist contributes to the understanding of complex biological systems, particularly in the regulation and signaling pathways affecting cellular behavior and immune responses.

The research topics they address include:

  • Hippo pathway signaling and YAP/TAZ
  • Invertebrate Immune Response Mechanisms
  • Plant Surface Properties and Treatments
  • Entomological Studies and Ecology
  • Neurobiology and Insect Physiology Research
  • Kruppel-like factors research
  • Wnt/β-catenin signaling in development and cancer

Frequent co-authors in their work include Qi Li, Junhao Mao, Jennifer L. Cotton, Xu Wu, and Zhipeng Tao. These collaborations have contributed to multiple joint publications in well-known journals.

Y. Tony Ip has published extensively in various scientific journals, with frequent publications appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Cell stem cell
  • Nature Communications
  • Cell Reports

Recent papers authored or co-authored by Y. Tony Ip include:

  • Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription, 2020, Cell Stem Cell
  • Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells, 2022, Nature Communications
  • Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila, 2022, Cell Reports
  • The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, 2020, Stem Cell Reports
  • TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila, 2023, Science Advances

Their body of work frequently investigates signaling pathways such as the Hippo pathway and Wnt/β-catenin signaling, both critical to understanding cellular proliferation, stem cell maintenance, and cancer biology. The integration of immunology and invertebrate models is another notable aspect of their research, contributing to knowledge on innate immune mechanisms and tissue homeostasis.

The scientist's work reflects an interdisciplinary approach combining molecular biology techniques to explore cellular signaling, mechanosensation in stem cell biology, and immune system regulation, often using invertebrate models such as Drosophila. This research contributes to fields ranging from developmental biology to cancer research.

Best Publications

  • Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development.

    Y Tony Ip;Roger J Davis

  • Dif, a dorsal-related gene that mediates an immune response in Drosophila

    Ip Yt;Reach M;Engstrom Y;Kadalayil L

  • A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

    H K Sluss;Z Han;T Barrett;R J Davis

  • Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila

    Alla Amcheslavsky;Jin Jiang;Y. Tony Ip

  • The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

    Y T Ip;R E Park;D Kosman;E Bier

  • The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.

    J. Jiang;D. Kosman;Y. T. Ip;Michael Steven Levine

  • Snail/slug family of repressors: slowly going into the fast lane of development and cancer.

    Kirugaval Hemavathy;Shovon Imtiaz Ashraf;Y. Tony Ip

  • Toll and IMD Pathways Synergistically Activate an Innate Immune Response in Drosophila melanogaster

    Takahiro Tanji;Xiaodi Hu;Alexander N. R. Weber;Y. Tony Ip

  • Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo.

    David Kosman;Y. Tony Ip;Michael Levine;Kavita Arora

  • Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways.

    Fangfang Ren;Bing Wang;Tao Yue;Eun Young Yun;Eun Young Yun

  • Regulators of the Toll and Imd pathways in the Drosophila innate immune response

    Takahiro Tanji;Y. Tony Ip

  • The dorsal Morphogen Is a Sequence-Specific DNA-Binding Protein That Interacts with a Long-Range Repression Element in Drosophila

    Y. Tony Ip;Rachel Kraut;Michael Steven Levine;Christine A. Rushlow

  • A Conserved p38 Mitogen-Activated Protein Kinase Pathway Regulates Drosophila Immunity Gene Expression

    Zhiqiang Stanley Han;Hervé Enslen;Xiaodi Hu;Xiangjun Meng

  • Identification of phosphatases for Smad in the BMP/DPP pathway.

    Hong B. Chen;Jiali Shen;Y. Tony Ip;Lan Xu

  • Human Slug is a repressor that localizes to sites of active transcription.

    Kirugaval Hemavathy;Siradanahalli C. Guru;John Harris;J. Don Chen

  • Multimerization and interaction of Toll and Spätzle in Drosophila.

    Xiaodi Hu;Yoshimasa Yagi;Takahiro Tanji;Sili L. Zhou

  • Pathogenic stimulation of intestinal stem cell response in Drosophila.

    Madhurima Chatterjee;Y. Tony Ip

  • Interaction and Specificity of Rel-related Proteins in Regulating Drosophila Immunity Gene Expression

    Z. Stanley Han;Y. Tony Ip

  • The Drosophila Toll-9 activates a constitutive antimicrobial defense.

    James Y Ooi;Yoshimasa Yagi;Xiaodi Hu;Y Tony Ip

  • Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila

    Alla Amcheslavsky;Wei Song;Wei Song;Qi Li;Yingchao Nie

Frequent Co-Authors

Jin Jiang
Jin Jiang The University of Texas Southwestern Medical Center
Lihua Julie Zhu
Lihua Julie Zhu University of Massachusetts Chan Medical School
Michael S. Levine
Michael S. Levine Princeton University
Randy L. Johnson
Randy L. Johnson The University of Texas MD Anderson Cancer Center
Xiao-Qiang Yu
Xiao-Qiang Yu South China Normal University
Xu Wu
Xu Wu Harvard University
Fernando D. Camargo
Fernando D. Camargo Harvard University
Michael P. Czech
Michael P. Czech University of Massachusetts Chan Medical School
Roger J. Davis
Roger J. Davis University of Massachusetts Chan Medical School
Norbert Perrimon
Norbert Perrimon Harvard University

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