World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
58
Citations
16913
World Ranking
3475
National Ranking
162

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Immune system
  • Antibody

Her primary areas of study are Immunology, Transplantation, Severe combined immunodeficiency, T cell and X-linked severe combined immunodeficiency. Her study brings together the fields of Virology and Immunology. Her Transplantation research incorporates elements of Superantigen and Bone marrow.

Her T cell study integrates concerns from other disciplines, such as Pathology, Rheumatoid arthritis, Epitope, Cytotoxic T cell and Autoimmunity. X-linked severe combined immunodeficiency is a subfield of Genetic enhancement that she explores. The concepts of her Genetic enhancement study are interwoven with issues in Enhancer, Regulation of gene expression, Cancer research and Retrovirus.

Her most cited work include:

  • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. (3006 citations)
  • Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1 (1314 citations)
  • Efficacy of Gene Therapy for X-Linked Severe Combined Immunodeficiency (484 citations)

What are the main themes of her work throughout her whole career to date?

Her primary areas of investigation include Immunology, T cell, Antigen, Virology and T-cell receptor. Her Immunology research integrates issues from Cytotoxic T cell and Severe combined immunodeficiency. The various areas that Annick Lim examines in her Severe combined immunodeficiency study include Phenotype, Genetic enhancement and Transplantation.

Her study looks at the relationship between Genetic enhancement and fields such as Cancer research, as well as how they intersect with chemical problems. Her research investigates the link between T cell and topics such as Rheumatoid arthritis that cross with problems in Subfamily and Epstein–Barr virus. Her work deals with themes such as Epitope, Cell culture and Gene, which intersect with Virology.

She most often published in these fields:

  • Immunology (80.56%)
  • T cell (31.48%)
  • Antigen (23.15%)

What were the highlights of her more recent work (between 2014-2019)?

  • Immunology (80.56%)
  • T-cell receptor (21.30%)
  • Virology (19.44%)

In recent papers she was focusing on the following fields of study:

Annick Lim mainly investigates Immunology, T-cell receptor, Virology, Immune system and Bullous pemphigoid. Her Immunology research is multidisciplinary, relying on both Cytotoxic T cell, Cancer research and Severe combined immunodeficiency. Her research in T-cell receptor intersects with topics in Degranulation, Calcium flux and Immunodeficiency.

She has researched Virology in several fields, including Interleukin 10, B-cell receptor, B cell and Regulatory B cells. Her research investigates the connection between Bullous pemphigoid and topics such as Rituximab that intersect with problems in Dermatology, Tumor necrosis factor alpha, Receptor and Monoclonal antibody. Her biological study spans a wide range of topics, including Epitope and T cell.

Between 2014 and 2019, her most popular works were:

  • Outcomes Following Gene Therapy in Patients With Severe Wiskott-Aldrich Syndrome (233 citations)
  • Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity (59 citations)
  • PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. (44 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Antibody

Her primary scientific interests are in Immunology, Immune system, Severe combined immunodeficiency, Virology and Immunotherapy. Her study in the field of Immune tolerance, Autoimmunity and CD8 also crosses realms of Respiratory tract infections and CX3CR1. Her Immune system study combines topics in areas such as Epitope, Antigen and HLA-DR Antigen.

Her Severe combined immunodeficiency research includes elements of DNA-PKcs, DNA-Dependent Protein Kinase Catalytic Subunit, Cancer research and Autoimmune regulator. The study incorporates disciplines such as Interleukin 10, B-cell receptor, B cell and Regulatory B cells in addition to Virology. Her research in Immunotherapy intersects with topics in Cancer cell and Cytokine.

Best Publications

  • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

    S. Hacein-Bey-Abina;C. Von Kalle;C. Von Kalle;M. Schmidt;M. P. McCormack

  • Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

    Salima Hacein-Bey-Abina;Alexandrine Garrigue;Gary P. Wang;Jean Soulier

  • Efficacy of Gene Therapy for X-Linked Severe Combined Immunodeficiency

    Salima Hacein-Bey-Abina;Julia Hauer;Annick Lim;Capucine Picard

  • egc, A Highly Prevalent Operon of Enterotoxin Gene, Forms a Putative Nursery of Superantigens in Staphylococcus aureus

    Sophie Jarraud;Marie Alix Peyrat;Annick Lim;Anne Tristan

  • A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

    Salima Hacein-Bey-Abina;Sung Yun Pai;H. Bobby Gaspar;Myriam Armant

  • Outcomes Following Gene Therapy in Patients With Severe Wiskott-Aldrich Syndrome

    Salima Hacein-Bey Abina;H. Bobby Gaspar;Johanna Blondeau;Laure Caccavelli

  • Implication of γδ T cells in the human immune response to cytomegalovirus

    Julie Déchanet;Pierre Merville;Annick Lim;Christelle Retière

  • Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies.

    Luis Borche;Annick Lim;Jacques-Louis Binet;Guillaume Dighiero

  • Long-Term Remissions of Severe Pemphigus After Rituximab Therapy Are Associated with Prolonged Failure of Desmoglein B Cell Response

    Natacha Colliou;Damien Picard;Frédérique Caillot;Sébastien Calbo

  • MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

    Nadine T. Nehme;Nadine T. Nehme;Jana Pachlopnik Schmid;Jana Pachlopnik Schmid;Franck Debeurme;Franck Debeurme;Isabelle André-Schmutz;Isabelle André-Schmutz

  • T Cell Response to Epstein-Barr Virus Transactivators in Chronic Rheumatoid Arthritis

    E Scotet;J David-Ameline;M A Peyrat;A Moreau-Aubry

  • The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct.

    Véronique Baron;Cécile Bouneaud;Ana Cumano;Annick Lim

  • A novel immunodeficiency associated with hypomorphic RAG1 mutations and CMV infection.

    Jean-Pierre de Villartay;Annick Lim;Hamoud Al-Mousa;Sophie Dupont

  • The Umbilical Cord Blood αβ T-Cell Repertoire: Characteristics of a Polyclonal and Naive but Completely Formed Repertoire

    Laurent Garderet;Nicolas Dulphy;Nicolas Dulphy;Corinne Douay;Corinne Douay;Nathalie Chalumeau;Nathalie Chalumeau

  • Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels.

    Benedetta Belloni;Mahzad Ziai;Annick Lim;Brigitte Lemercier

  • Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes

    Emmanuel Scotet;Marie-Alix Peyrat;Xavier Saulquin;Christelle Retiere

  • A poliovirus neutralization epitope expressed on hybrid hepatitis B surface antigen particles

    F Delpeyroux;N Chenciner;A Lim;Y Malpiece

  • B-Cell Depletion Immunotherapy in Pemphigus: Effects on Cellular and Humoral Immune Responses

    Hugo Mouquet;Philippe Musette;Marie-Lyse Gougeon;Serge Jacquot

  • Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation

    Despina Moshous;Despina Moshous;Despina Moshous;Emmanuel Martin;Emmanuel Martin;Wassila Carpentier;Annick Lim

  • Inherited and Somatic CD3ζ Mutations in a Patient with T-Cell Deficiency

    Frédéric Rieux-Laucat;Claire Hivroz;Annick Lim;Véronique Mateo

  • Efficacy of gene therapy for X-linked severe combined immunodeficiency: update on trial No.1 follow-up and preliminary results of multicentric collaborative trial No. 2 (Paris - Boston - London)

    S Hacein-Bey-Abina;L Caccaveli;F Touzot;L Dal-Cortivo

Frequent Co-Authors

Alain Fischer
Alain Fischer Collège de France
Capucine Picard
Capucine Picard Université Paris Cité
Francis Delpeyroux
Francis Delpeyroux Institut Pasteur
Jean-Pierre de Villartay
Jean-Pierre de Villartay Université Paris Cité
Philippe Kourilsky
Philippe Kourilsky Collège de France
Stéphane Blanche
Stéphane Blanche Université Paris Cité
Antoine Toubert
Antoine Toubert Université Paris Cité
Marina Cavazzana-Calvo
Marina Cavazzana-Calvo Necker-Enfants Malades Hospital
Sylvain Latour
Sylvain Latour Institut Imagine

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