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Georges Leclercq

Georges Leclercq

D-Index & Metrics

Immunology

D-Index
48
Citations
6964
World Ranking
4455
National Ranking
73

Overview

Georges Leclercq is affiliated with Ghent University in Belgium and has a substantial body of research primarily focused on immunology and related biomedical fields. Their work spans various disciplines within the life sciences, including immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology.

The main fields of study associated with Georges Leclercq include:

  • Immunology and Microbiology
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader areas, their research covers several subfields, notably:

  • Immunology
  • Molecular Biology
  • Oncology
  • Hematology
  • Infectious Diseases

Leclercq's work broadly addresses critical topics related to immune system function and therapeutic approaches. The principal topics include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • Single-cell and spatial transcriptomics
  • Immunotherapy and Immune Responses
  • IL-33, ST2, and ILC Pathways
  • Nanowire Synthesis and Applications

Their recent published papers demonstrate a focus on the development and regulation of immune cells, especially T cells and natural killer cells, as well as immune responses in disease contexts. These publications include:

  • Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes, 2020, Immunity
  • The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation, 2020, Blood
  • Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development, 2020, Nature Immunology
  • T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells, 2021, Frontiers in Immunology
  • Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates, 2022, Frontiers in Immunology

Georges Leclercq frequently collaborates with several researchers, reflecting a strong network within the immunology research community. The top co-authors include:

  • Tom Taghon
  • Bart Vandekerckhove
  • Filip Van Nieuwerburgh
  • Pieter Van Vlierberghe
  • Tessa Kerre

Publication venues where Leclercq's research most often appears include:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences
  • Nature Immunology
  • OncoImmunology

Best Publications

  • Generation of T Cells from Human Embryonic Stem Cell-Derived Hematopoietic Zones

    Frank Timmermans;Imke Velghe;Lieve Vanwalleghem;Magda De Smedt

  • Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ

    Hilde Kelchtermans;Bert De Klerck;Tania Mitera;Maarten Van Balen

  • CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets

    Mireille T. M. Vossen;Mourad Matmati;Kirsten M. L. Hertoghs;Paul A. Baars

  • Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.

    G Leclercq;V Debacker;M de Smedt;J Plum

  • Interleukin-7 Is a Critical Growth Factor in Early Human T-Cell Development

    J Plum;M De Smedt;G Leclercq;B Verhasselt

  • Mouse TCRαβ+CD8αα Intraepithelial Lymphocytes Express Genes That Down-Regulate Their Antigen Reactivity and Suppress Immune Responses

    Timothy L. Denning;Steve Granger;Daniel Mucida;Ryan Graddy

  • Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis

    Hilde Kelchtermans;Lies Geboes;Tania Mitera;Dana Huskens

  • β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination

    Rebecca De Smet;Tine Demoor;Stephanie Verschuere;Melissa Dullaers

  • A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHC Class I for Natural Killer Cell Education

    Anick Chalifour;Léonardo Scarpellino;Jonathan Back;Petter Brodin

  • Active Form of Notch Imposes T Cell Fate in Human Progenitor Cells

    Magda De Smedt;Katia Reynvoet;Tessa Kerre;Tom Taghon

  • An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells

    Inge Van de Walle;Greet De Smet;Magda De Smedt;Bart Vandekerckhove

  • KLRG1 binds cadherins and preferentially associates with SHIP-1.

    Marlowe S. Tessmer;Céline Fugere;Frederik Stevenaert;Olga V. Naidenko

  • Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases.

    Roosmarijn E. Vandenbroucke;Eline Dejonckheere;Philippe Van Lint;Delphine Demeestere

  • Interactions of Ly49 Family Receptors with MHC Class I Ligands in trans and cis

    Léonardo Scarpellino;Franziska Oeschger;Philippe Guillaume;Jérôme D. Coudert

  • Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

    Inge Van de Walle;Els Waegemans;Jelle De Medts;Greet De Smet

  • Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes.

    Marieke Lavaert;Kai Ling Liang;Niels Vandamme;Jong-Eun Park

  • Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment

    Magda De Smedt;Inge Hoebeke;Katia Reynvoet;Georges Leclercq

  • Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants.

    D Vanhecke;Georges Leclercq;Jean Plum;Bart Vandekerckhove

  • T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34+CD38-CD7+ common lymphoid progenitors expressing lymphoid-specific genes

    I Hoebeke;M De Smedt;F Stolz;F Stolz;K Pike-Overzet

  • Systemic Juvenile Idiopathic Arthritis–like Syndrome in Mice Following Stimulation of the Immune System With Freund's Complete Adjuvant: Regulation by Interferon-γ

    Anneleen Avau;Tania Mitera;Stéphanie Put;Karen Put

  • Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/- precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture.

    J Plum;M De Smedt;G Leclercq

Frequent Co-Authors

Jean Plum
Jean Plum Ghent University
Tom Taghon
Tom Taghon Ghent University
Dirk Elewaut
Dirk Elewaut Ghent University
Werner Held
Werner Held University of Lausanne
Mitchell Kronenberg
Mitchell Kronenberg University of California, San Diego
Dieter Deforce
Dieter Deforce Ghent University
Yvan Saeys
Yvan Saeys Ghent University
Sarah A. Teichmann
Sarah A. Teichmann University of Cambridge
Aviv Regev
Aviv Regev Genentech

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