World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
15721
World Ranking
10132
National Ranking
180

Overview

Werner Held is affiliated with the University of Lausanne in Switzerland. Their research primarily focuses on the fields of Immunology and Microbiology, with additional contributions to Medicine. The scientist's subfields of study include Immunology, Oncology, Molecular Biology, Nutrition and Dietetics, and Epidemiology.

The main topics of Werner Held's work cover:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Single-cell and spatial transcriptomics
  • IL-33, ST2, and ILC Pathways

Werner Held has published extensively in notable venues, frequently contributing to the following journals:

  • Immunity
  • Nature Immunology
  • Science Immunology
  • Cell Reports
  • Cancer Cell

Selected recent papers by Werner Held include:

  • "The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8+ T cells against cancer," 2024, Nature
  • "Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity," 2021, Nature Immunology
  • "Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation," 2020, Immunity
  • "Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq," 2020, OncoImmunology
  • "The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection," 2023, Immunity

Werner Held collaborates frequently with other researchers, including:

  • Mélanie Charmoy
  • Fabien Franco
  • Ping-Chih Ho
  • Tania Wyss
  • Daniel E. Speiser

Best Publications

  • Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.

    Imran Siddiqui;Karin Schaeuble;Vijaykumar Chennupati;Silvia A. Fuertes Marraco

  • Defining ‘T cell exhaustion’

    Christian U Blank;W Nicholas Haining;Werner Held;Patrick G Hogan;Patrick G Hogan

  • T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections

    Daniel T. Utzschneider;Mélanie Charmoy;Vijaykumar Chennupati;Laurène Pousse

  • The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

    Jens Zerrahn;Werner Held;David H Raulet

  • Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

    Anita Wolfer;Talitha Bakker;Anne Wilson;Michael Nicolas

  • MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer

    Jan C. Dudda;Bruno Salaun;Yun Ji;Douglas C. Palmer

  • Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

    Grégoire Jeannet;Caroline Boudousquié;Noémie Gardiol;Joonsoo Kang

  • Two waves of recombinase gene expression in developing thymocytes.

    A Wilson;W Held;H R MacDonald

  • The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.

    Vassilios Ioannidis;Friedrich Beermann;Hans Clevers;Werner Held

  • Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand–expressing tumor cells

    Jérôme D. Coudert;Jacques Zimmer;Jacques Zimmer;Jacques Zimmer;Elena Tomasello;Elena Tomasello;Elena Tomasello;Marek Cebecauer;Marek Cebecauer;Marek Cebecauer

  • Specificity, tolerance and developmental regulation of natural killer cells defined by expression of class I-specific Ly49 receptors.

    David H. Raulet;Werner Held;Isabel Correa;Jeffrey R. Dorfman

  • Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin

    Grégoire Jeannet;Marina Scheller;Léonardo Scarpellino;Stéphane Duboux

  • Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity.

    Yugang Guo;Yu Qing Xie;Min Gao;Yang Zhao

  • Cis association of Ly49A with MHC class I restricts natural killer cell inhibition.

    Marie-Agnès Doucey;Léonardo Scarpellino;Jacques Zimmer;Philippe Guillaume

  • Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission

    Werner Held;Gary A. Waanders;Alexander N. Shakhov;Léonardo Scarpellino

  • TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation.

    Dominik Wieland;Janine Kemming;Anita Schuch;Florian Emmerich

  • Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells.

    Werner Held;Jacques Roland;David H. Raulet

  • Natural killer cell receptors: The offs and ons of NK cell recognition

    David H Raulet;Werner Held

  • Regulation of γδ Versus αß T Lymphocyte Differentiation by the Transcription Factor SOX13

    Heather J. Melichar;Kavitha Narayan;Sandy D. Der;Yoshiki Hiraoka

  • Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways

    Jérôme D. Coudert;Léonardo Scarpellino;Frédéric Gros;Eric Vivier;Eric Vivier

Frequent Co-Authors

H. Robson MacDonald
H. Robson MacDonald University of Lausanne
David H. Raulet
David H. Raulet University of California, Berkeley
Mauro Delorenzi
Mauro Delorenzi University of Lausanne
Dietmar Zehn
Dietmar Zehn Technical University of Munich
Eric Vivier
Eric Vivier Aix-Marseille University
Georges Leclercq
Georges Leclercq Ghent University
David Gfeller
David Gfeller University of Lausanne
Daniel E. Speiser
Daniel E. Speiser University of Lausanne
Friedrich Beermann
Friedrich Beermann École Polytechnique Fédérale de Lausanne
Christoph Mueller
Christoph Mueller University of Bern

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Werner Held

Trending Scientists

Recently Published Articles