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Neuroscience

D-Index
61
Citations
13004
World Ranking
3685
National Ranking
143

Overview

Alain M. Gardier is affiliated with the University of Paris-Saclay in France. Their research work primarily spans the fields of Neuroscience and Medicine, with significant contributions in Pharmacology and Cellular and Molecular Neuroscience. They also focus on Biological Psychiatry, Developmental Neuroscience, and Psychiatry and Mental Health as subfields of study.

The scientist's research topics encompass several areas, including:

  • Treatment of Major Depression
  • Neuroscience and Neuropharmacology Research
  • Tryptophan and Brain Disorders
  • Neurogenesis and Neuroplasticity Mechanisms
  • Stress Responses and Cortisol
  • Memory and Neural Mechanisms
  • Electroconvulsive Therapy Studies

Gardier has published multiple papers, with recent notable works such as:

  • Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine, 2020, Neuropsychopharmacology
  • Ketamine and esketamine in suicidal thoughts and behaviors: a systematic review, 2023, Therapeutic Advances in Psychopharmacology
  • Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine, 2020, Pharmacology Biochemistry and Behavior
  • Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine, 2021, Proceedings of the National Academy of Sciences
  • Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory/inhibitory synaptic activity, 2022, Neuropharmacology

Frequent collaborators in Gardier's work include:

  • Denis J. David
  • Indira Mendez-David
  • Emmanuelle Corruble
  • Romain Colle
  • Thi Mai Loan Nguyen

They have contributed extensively to journals such as:

  • Biological Psychiatry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuropharmacology
  • Fundamental and Clinical Pharmacology
  • Neuropsychopharmacology

Their scholarly output primarily addresses the neurobiological and pharmacological mechanisms underlying treatment for major depression and related psychiatric conditions. Gardier's research includes investigations into the effects and mechanisms of ketamine and related compounds, with particular attention to receptor activity, synaptic balance, and neuroplasticity.

Best Publications

  • Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

    Denis J. David;Benjamin Adam Samuels;Quentin Rainer;Jing Wen Wang

  • Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors.

    U. Maskos;B. E. Molles;S. Pons;M. Besson;M. Besson

  • Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

    Nicolas Champtiaux;Cecilia Gotti;Matilde Cordero-Erausquin;Denis J. David

  • 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants

    Jesse W. Richardson-Jones;Caryne P. Craige;Bruno P. Guiard;Alisson Stephen

  • Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression.

    Jean-Philippe Guilloux;Gaelle Douillard-Guilloux;Rama Kota;Xingbin Wang

  • Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors.

    Marubio Lm;Marubio Lm;Gardier Am;Durier S;David D

  • Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior

    Rebecca A. Brachman;Josephine C. McGowan;Jennifer N. Perusini;Sean C. Lim

  • BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

    G Quesseveur;D J David;M C Gaillard;M C Gaillard;P Pla

  • Role of 5-HT1A autoreceptors in the mechanism of action of serotoninergic antidepressant drugs: recent findings from in vivo microdialysis studies.

    A.M. Gardier;I. Malagié;A.C. Trillat;C. Jacquot

  • Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety

    J. W. Richardson-Jones;C. P. Craige;T. H. Nguyen;H. F. Kung

  • Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study.

    Isabelle Malagié;Anne-Cécile Trillat;Christian Jacquot;Alain M. Gardier

  • VGLUT3 (Vesicular Glutamate Transporter Type 3) Contribution to the Regulation of Serotonergic Transmission and Anxiety

    Bénédicte Amilhon;Ève Lepicard;Thibault Renoir;Raymond Mongeau

  • Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies.

    Thu Ha Pham;Alain M. Gardier

  • Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice.

    T. Deltheil;B.P. Guiard;J. Cerdan;D.J. David;D.J. David

  • Rapid Anxiolytic Effects of a 5-HT 4 Receptor Agonist Are Mediated by a Neurogenesis-Independent Mechanism

    Indira Mendez-David;Denis J David;Flavie Darcet;Melody V Wu

  • Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement

    S. Tolu;S. Tolu;R. Eddine;F. Marti;V. David

  • Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response

    A. Bacq;L. Balasse;L. Balasse;G. Biala;B. Guiard

  • 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization.

    Nicolas Froger;Alain M. Gardier;Rosario Moratalla;Israel Alberti

  • The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein.

    Sylvain J. Robert;José L. Zugaza;Rodolphe Fischmeister;Alain M. Gardier

  • Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety

    Quentin Rainer;Lin Xia;Jean-Philippe Guilloux;Cecilia Gabriel

Frequent Co-Authors

Jean-Philippe Guilloux
Jean-Philippe Guilloux University of Paris-Saclay
Bruno P. Guiard
Bruno P. Guiard University of Toulouse-Jean Jaurès
René Hen
René Hen Columbia University
Jean-Pierre Changeux
Jean-Pierre Changeux Institut Pasteur
Uwe Maskos
Uwe Maskos Institut Pasteur
Laurence Lanfumey
Laurence Lanfumey Université Paris Cité
Catherine Belzung
Catherine Belzung François Rabelais University
Stephen P. Hunt
Stephen P. Hunt University College London
Kenji F. Tanaka
Kenji F. Tanaka Keio University
Ivan Assenmacher
Ivan Assenmacher University of Montpellier

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