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D-Index & Metrics

Microbiology

D-Index
66
Citations
15124
World Ranking
2405
National Ranking
971

Overview

Sandra M. McLachlan is affiliated with the University of California, Los Angeles in the United States. Their research primarily focuses on the field of medicine with a specialization in endocrinology, diabetes and metabolism. Additional subfields include genetics, immunology, physiology, and oncology.

The main topics covered in their work are as follows:

  • Diabetes and associated disorders
  • Thyroid Disorders and Treatments
  • Erythrocyte Function and Pathophysiology
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses

The scientist has published research in several peer-reviewed journals and venues, including:

  • Thyroid
  • Frontiers in Immunology
  • Cancer Immunology Immunotherapy
  • Journal of the Endocrine Society
  • VideoEndocrinology

Among their recent papers are the following:

  • "Discoveries in Thyroid Autoimmunity in the Past Century," 2022, published in Thyroid
  • "The NOD Mouse Beyond Autoimmune Diabetes," 2022, published in Frontiers in Immunology
  • "Peri-tumor administration of controlled release anti-CTLA-4 synergizes with systemic anti-PD-1 to induce systemic antitumor immunity while sparing autoimmune toxicity," 2020, published in Cancer Immunology Immunotherapy
  • "Deborah Doniach: Discovering Thyroid Autoimmunity: The End of Horror Autotoxicus," 2020, published in Thyroid
  • "Insulin-like Growth Factor 1 and Prolactin Levels in Chimpanzees (Pan troglodytes) Across the Lifespan," 2021, published in Journal of the Endocrine Society

Frequent collaborators in their research include:

  • Basil Rapoport
  • Holly A. Aliesky
  • A. Aubin
  • Félix Lombard-Vadnais
  • Roxanne Collin

Best Publications

  • Autoantibodies to the thyrotropin receptor.

    Bernard Rees Smith;Sandra Melissa McLACHLAN;Jadwiga Furmaniak

  • The Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies

    Basil Rapoport;Gregorio D. Chazenbalk;Juan Carlos Jaume;Sandra M. McLachlan

  • Mechanisms of Autoantibody-Induced Pathology.

    Ralf J. Ludwig;Karen Vanhoorelbeke;Frank Leypoldt;Ziya Kaya

  • Lack of promiscuity in autoantigen-specific H and L chain combinations as revealed by human H and L chain "roulette".

    S Portolano;G D Chazenbalk;J S Hutchison;S M McLachlan

  • Carbimazole and the autoimmune response in Graves' disease.

    Alan M. McGregor;Meryl M. Petersen;Sandra M. McLachlan;Patricia Rooke

  • Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein-Barr virus-induced B-cell lines.

    A. Graham Bird;Sandra M. McLachlan;Sven Britton

  • Vitamin D Deficiency in Mice Impairs Colonic Antibacterial Activity and Predisposes to Colitis

    Venu Lagishetty;Alexander V. Misharin;Nancy Q. Liu;Thomas S. Lisse

  • The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim

    Chun-Rong Chen;Pavel Pichurin;Yuji Nagayama;Francesco Latrofa

  • The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease.

    Sandra M. McLACHLAN;Basil Rapoport

  • Breaking Tolerance to Thyroid Antigens: Changing Concepts in Thyroid Autoimmunity

    Sandra M. McLachlan;Basil Rapoport

  • Thyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa.

    Sandra M. McLachlan;Basil Rapoport

  • Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase.

    K Beever;J Bradbury;D Phillips;S M McLachlan

  • Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ.

    G D Chazenbalk;S Portolano;D Russo;J S Hutchison

  • Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor

    Gregorio D. Chazenbalk;Pavel Pichurin;Chun-Rong Chen;Francesco Latrofa

  • The thyrotropin receptor in Graves' disease.

    Basil Rapoport;Sandra M. McLachlan

  • Insight into Graves' hyperthyroidism from animal models.

    Sandra M. McLachlan;Yuji Nagayama;Basil Rapoport

  • The Link between Graves’ Disease and Hashimoto’s Thyroiditis: A Role for Regulatory T Cells

    Sandra M. McLachlan;Yuji Nagayama;Pavel N. Pichurin;Yumiko Mizutori

  • Why measure thyroglobulin autoantibodies rather than thyroid peroxidase autoantibodies

    Sandra M. McLachlan;Basil Rapoport

  • Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease.

    Basil Rapoport;Randa Alsabeh;David Aftergood;Sandra M. McLachlan

  • Engineering the Human Thyrotropin Receptor Ectodomain from a Non-secreted Form to a Secreted, Highly Immunoreactive Glycoprotein That Neutralizes Autoantibodies in Graves' Patients' Sera

    Gregorio D. Chazenbalk;Juan Carlos Jaume;Sandra M. McLachlan;Basil Rapoport

Frequent Co-Authors

Basil Rapoport
Basil Rapoport University of California, San Francisco
Bernard Rees Smith
Bernard Rees Smith Cardiff University
Robert W. Williams
Robert W. Williams University of Tennessee Health Science Center
Anne M. Dickinson
Anne M. Dickinson Newcastle University
John C. Morris
John C. Morris Washington University in St. Louis
Masami Niwa
Masami Niwa Nagasaki University
Ramachandran Murali
Ramachandran Murali Cedars-Sinai Medical Center
Chella S. David
Chella S. David Mayo Clinic
Wilmar M. Wiersinga
Wilmar M. Wiersinga University of Amsterdam
Meena Upadhyaya
Meena Upadhyaya Cardiff University

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