World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
72
Citations
28456
World Ranking
2094
National Ranking
953

Overview

Malachi Griffith is affiliated with Washington University in St. Louis in the United States. Their academic work spans multiple disciplines primarily within biochemistry, genetics, and molecular biology, as well as medicine. The focus of their research includes molecular biology, cancer research, genetics, immunology, and oncology.

The main topics addressed in their publications cover cancer genomics and diagnostics, genomics and rare diseases, immunotherapy and immune responses, genetic factors in colorectal cancer, cancer immunotherapy and biomarkers, biomedical text mining and ontologies, and vaccines and immunoinformatics approaches.

Griffith's research output includes notable papers published in respected journals. Recent papers include:

  • Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts, 2020, Nucleic Acids Research
  • Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial, 2020, Clinical Cancer Research
  • DGIdb 5.0: rebuilding the drug-gene interaction database for precision medicine and drug discovery platforms, 2023, Nucleic Acids Research
  • GA4GH: International policies and standards for data sharing across genomic research and healthcare, 2021, Cell Genomics
  • pVACtools: A Computational Toolkit to Identify and Visualize Cancer Neoantigens, 2020, Cancer Immunology Research

Frequent co-authors of Malachi Griffith include Obi L. Griffith, Arpad Danos, Alex H. Wagner, Jason Saliba, and Zachary L. Skidmore. The extent of collaboration with these individuals is reflected in multiple joint publications.

The scientist's work often appears in venues such as Cancer Genetics, Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Blood, and Clinical Cancer Research, indicating a focus on cancer and biomedical research.

Best Publications

  • The clonal and mutational evolution spectrum of primary triple-negative breast cancers

    Sohrab P. Shah;Andrew Roth;Rodrigo Goya;Arusha Oloumi

  • Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

    Ryan D Morin;María Méndez-Lago;Andrew J Mungall;Rodrigo Goya

  • Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells.

    Ryan D Morin;Michael D O'Connor;Malachi Griffith;Florian Kuchenbauer

  • Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

    Ramaswamy Govindan;Li Ding;Malachi Griffith;Janakiraman Subramanian

  • De novo assembly and analysis of RNA-seq data

    Gordon Robertson;Jacqueline Schein;Readman Chiu;Richard Corbett

  • DGIdb 3.0: a redesign and expansion of the drug-gene interaction database.

    Kelsy C Cotto;Alex H Wagner;Yang-Yang Feng;Susanna Kiwala

  • The status, quality, and expansion of the NIH full-length cDNA project: The Mammalian Gene Collection (MGC)

    Daniela S. Gerhard;Lukas Wagner;Elise A. Feingold;Carolyn M. Shenmen

  • Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts.

    Sharon L Freshour;Susanna Kiwala;Kelsy C Cotto;Adam C Coffman

  • Defuse: An algorithm for gene fusion discovery in tumor rna-seq data

    Andrew McPherson;Fereydoun Hormozdiari;Abdalnasser Zayed;Ryan Giuliany

  • Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

    Dejan Juric;Pau Castel;Malachi Griffith;Obi L. Griffith

  • CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer

    Malachi Griffith;Nicholas C. Spies;Kilannin Krysiak;Joshua F. McMichael

  • DGIdb: mining the druggable genome

    Malachi Griffith;Obi L Griffith;Adam C Coffman;James V Weible

  • SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.

    Christopher A. Miller;Brian S. White;Nathan D. Dees;Malachi Griffith

  • Functional heterogeneity of genetically defined subclones in acute myeloid leukemia

    Jeffery M. Klco;David H. Spencer;Christopher A. Miller;Malachi Griffith

  • DGIdb 2.0: mining clinically relevant drug-gene interactions.

    Alex H. Wagner;Adam C. Coffman;Benjamin J. Ainscough;Nicholas C. Spies

  • Alternative expression analysis by RNA sequencing.

    Malachi Griffith;Malachi Griffith;Obi L Griffith;Obi L Griffith;Jill Mwenifumbo;Rodrigo Goya

  • pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens.

    Jasreet Hundal;Beatriz M. Carreno;Allegra A. Petti;Gerald P. Linette

  • Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

    Jeffery M. Klco;Christopher A. Miller;Malachi Griffith;Allegra Petti

  • Mitelman Database (Chromosome Aberrations and Gene Fusions in Cancer)

    Malachi Griffith;Obi L. Griffith

  • Integration of the Drug-Gene Interaction Database (DGIdb) with open crowdsource efforts

    Sharon Freshour;Susanna Kiwala;Kelsy C. Cotto;Adam C. Coffman

Frequent Co-Authors

Obi L. Griffith
Obi L. Griffith Washington University in St. Louis
Elaine R. Mardis
Elaine R. Mardis The Ohio State University
Robert S. Fulton
Robert S. Fulton Washington University in St. Louis
Steven J.M. Jones
Steven J.M. Jones University of British Columbia
Marco A. Marra
Marco A. Marra University of British Columbia
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital
David E. Larson
David E. Larson Washington University in St. Louis
Vincent Magrini
Vincent Magrini The Ohio State University
Catrina Fronick
Catrina Fronick Washington University in St. Louis
Todd A. Fehniger
Todd A. Fehniger Washington University in St. Louis

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