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Immunology

D-Index
67
Citations
28628
World Ranking
2635
National Ranking
1255

Overview

Todd A. Fehniger is affiliated with Washington University in St. Louis, United States. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, with extensive work in Immunology, Oncology, Molecular Biology, Pathology and Forensic Medicine, and Hematology. The main topics of their research include Immune Cell Function and Interaction, CAR-T cell therapy research, Lymphoma Diagnosis and Treatment, T-cell and B-cell Immunology, Immunotherapy and Immune Responses, Immune cells in cancer, and Monoclonal and Polyclonal Antibodies Research.

Fehniger has contributed to a number of scientific publications, with recent notable papers including:

  • CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas, 2020, Blood
  • Allogeneic natural killer cell therapy, 2022, Blood
  • Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant, 2021, Blood
  • Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies, 2021, Clinical Cancer Research
  • Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia, 2020, Cancer Discovery

Frequent co-authors who have collaborated extensively with Fehniger include:

  • Melissa M. Berrien-Elliott
  • Amanda F. Cashen
  • David A. Russler-Germain
  • Michelle Becker-Hapak
  • Pamela Wong

Fehniger's research contributions have often appeared in leading publication venues. These include Blood, bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, European Journal of Immunology, and Clinical Lymphoma Myeloma & Leukemia. The majority of their published work can be found in Blood, with 28 contributions.

Best Publications

  • The biology of human natural killer-cell subsets.

    Megan A Cooper;Todd A Fehniger;Michael A Caligiuri

  • Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset

    Megan A. Cooper;Todd A. Fehniger;Sarah C. Turner;Kenneth S. Chen

  • Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

    Xuefang Cao;Sheng F. Cai;Todd A. Fehniger;Jiling Song

  • Interleukin 15: biology and relevance to human disease

    Todd A. Fehniger;Michael A. Caligiuri

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  • CD56bright natural killer cells are present in human lymph nodes and are activated by T cell–derived IL-2: a potential new link between adaptive and innate immunity

    Todd A Fehniger;Megan A Cooper;Gerard J Nuovo;Marina Cella

  • Differential Cytokine and Chemokine Gene Expression by Human NK Cells Following Activation with IL-18 or IL-15 in Combination with IL-12: Implications for the Innate Immune Response

    Todd A. Fehniger;Manisha H. Shah;Matthew J. Turner;Jeffrey B. VanDeusen

  • Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

    Rizwan Romee;Maximillian Rosario;Melissa M. Berrien-Elliott;Julia A. Wagner

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes

    John S. Welch;Allegra A. Petti;Christopher A. Miller;Catrina C. Fronick

  • Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect.

    Sherif S. Farag;Todd A. Fehniger;Todd A. Fehniger;Loredana Ruggeri;Loredana Ruggeri;Andrea Velardi;Andrea Velardi

  • Cytokine activation induces human memory-like NK cells.

    Rizwan Romee;Stephanie E. Schneider;Jeffrey W. Leong;Julie M. Chase

  • NK cell and DC interactions.

    Megan A. Cooper;Todd A. Fehniger;Anja Fuchs;Marco Colonna

  • In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells.

    Megan A. Cooper;Jennifer E. Bush;Todd A. Fehniger;Jeffrey B. VanDeusen

  • Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.

    Todd A. Fehniger;Sheng F. Cai;Xuefang Cao;Andrew J. Bredemeyer

  • A potential role for interleukin-15 in the regulation of human natural killer cell survival.

    W E Carson;T A Fehniger;S Haldar;K Eckhert

  • Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells

    Todd A. Fehniger;Kazuhiro Suzuki;Anand Ponnappan;Jeffrey B. VanDeusen

  • First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation

    Rizwan Romee;Sarah Cooley;Melissa M. Berrien-Elliott;Peter Westervelt

  • Interleukin-2 and interleukin-15: immunotherapy for cancer.

    Todd A Fehniger;Megan A Cooper;Michael A Caligiuri

  • Differential expression and function of L-selectin on CD56bright and CD56dim natural killer cell subsets.

    Margaret Frey;Nalini B. Packianathan;Todd A. Fehniger;Mary E. Ross

Frequent Co-Authors

John F. DiPersio
John F. DiPersio Washington University in St. Louis
Michael A. Caligiuri
Michael A. Caligiuri City Of Hope National Medical Center
Nancy L. Bartlett
Nancy L. Bartlett Washington University in St. Louis
Peter Westervelt
Peter Westervelt Brown University
Ravi Vij
Ravi Vij Washington University in St. Louis
Megan A. Cooper
Megan A. Cooper Washington University in St. Louis
Timothy J. Ley
Timothy J. Ley Washington University in St. Louis
Obi L. Griffith
Obi L. Griffith Washington University in St. Louis
Malachi Griffith
Malachi Griffith Washington University in St. Louis
Elaine R. Mardis
Elaine R. Mardis The Ohio State University

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Related Online Degrees & Career Pathways

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