World's Best Scientists 2026 revealed!
Yoshihiko Hirohashi

Yoshihiko Hirohashi

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
8122
World Ranking
18065
National Ranking
1302

Overview

Yoshihiko Hirohashi is affiliated with Sapporo Medical University in Japan and primarily conducts research in the fields of Medicine and Immunology and Microbiology. Their work spans several subfields, including Oncology, Immunology, Molecular Biology, Cancer Research, and Surgery.

The main topics addressed in Hirohashi's research focus on Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, Immune Cell Function and Interaction, CAR-T cell therapy research, Bladder and Urothelial Cancer Treatments, Cancer Cells and Metastasis, and T-cell and B-cell Immunology.

Frequent coauthors collaborating with Hirohashi include:

  • Toshihiko Torigoe
  • Takayuki Kanaseki
  • Tomohide Tsukahara
  • Terufumi Kubo
  • Kenji Murata

Hirohashi often publishes in several academic journals and venues, with the most frequent including:

  • Anticancer Research
  • Cancer Science
  • Medical Molecular Morphology
  • Immunological Medicine
  • Cancer Immunology Immunotherapy

Selected recent papers by Hirohashi illustrate the scope of their work:

  • "Aldolase A promotes epithelial-mesenchymal transition to increase malignant potentials of cervical adenocarcinoma" (2020, Cancer Science)
  • "A screening assistance system for cervical cytology of squamous cell atypia based on a two-step combined CNN algorithm with label smoothing" (2021, Cancer Medicine)
  • "CD8+ T-cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA PVT1" (2021, Cancer Immunology Research)
  • "Association between radiotherapy-induced alteration of programmed death ligand 1 and survival in patients with uterine cervical cancer undergoing preoperative radiotherapy" (2020, Strahlentherapie und Onkologie)
  • "Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair-deficient colorectal cancer tissue" (2021, JCI Insight)

Best Publications

  • Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells.

    Hiroko Asanuma;Toshihiko Torigoe;Kenjiro Kamiguchi;Yoshihiko Hirohashi

  • An HLA-A24-restricted Cytotoxic T Lymphocyte Epitope of a Tumor-associated Protein, Survivin

    Yoshihiko Hirohashi;Toshihiko Torigoe;Akiko Maeda;Yuki Nabeta

  • Aberrant Expression and Potency as a Cancer Immunotherapy Target of Inhibitor of Apoptosis Protein Family, Livin/ML-IAP in Lung Cancer

    Hiroyuki Hariu;Yoshihiko Hirohashi;Toshihiko Torigoe;Hiroko Asanuma

  • Phase I clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer

    Tetsuhiro Tsuruma;Fumitake Hata;Toshihiko Torigoe;Tomohisa Furuhata

  • Detection of autoantibodies to livin and survivin in Sera from lung cancer patients.

    Atsuhito Yagihashi;Koichi Asanuma;Daisuke Kobayashi;Naoki Tsuji

  • A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins

    Satomi Idenoue;Yoshihiko Hirohashi;Toshihiko Torigoe;Yuriko Sato

  • Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.

    R. Yamada;A. Takahashi;T. Torigoe;R. Morita

  • Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients.

    Jun-ichi Kobayashi;Toshihiko Torigoe;Yoshihiko Hirohashi;Satomi Idenoue

  • Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells.

    Satoko Inoda;Yoshihiko Hirohashi;Toshihiko Torigoe;Rena Morita

  • HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem-like Cells

    Satoshi Nishizawa;Yoshihiko Hirohashi;Toshihiko Torigoe;Akari Takahashi

  • SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity

    Munehide Nakatsugawa;Akari Takahashi;Yoshihiko Hirohashi;Toshihiko Torigoe

  • ALDH1-High Ovarian Cancer Stem-Like Cells Can Be Isolated from Serous and Clear Cell Adenocarcinoma Cells, and ALDH1 High Expression Is Associated with Poor Prognosis

    Takafumi Kuroda;Yoshihiko Hirohashi;Toshihiko Torigoe;Kazuyo Yasuda

  • Efficient Cross-Presentation by Heat Shock Protein 90-Peptide Complex-Loaded Dendritic Cells via an Endosomal Pathway

    Takehiro Kurotaki;Yasuaki Tamura;Gosei Ueda;Gosei Ueda;Jun Oura

  • Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma.

    Satoko Inoda;Yoshihiko Hirohashi;Toshihiko Torigoe;Munehide Nakatsugawa

  • Clinical and immunological evaluation of anti-apoptosis protein, survivin-derived peptide vaccine in phase I clinical study for patients with advanced or recurrent breast cancer

    Tetsuhiro Tsuruma;Yuji Iwayama;Tosei Ohmura;Tadashi Katsuramaki

  • Immune responses to human cancer stem-like cells/cancer-initiating cells.

    Yoshihiko Hirohashi;Toshihiko Torigoe;Tomohide Tsukahara;Takayuki Kanaseki

  • Immunotherapeutic benefit of α-interferon (IFNα) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients.

    Hidekazu Kameshima;Tetsuhiro Tsuruma;Goro Kutomi;Hiroaki Shima

  • Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcoma.

    Yuriko Sato;Yuki Nabeta;Tomohide Tsukahara;Yoshihiko Hirohashi

  • Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor.

    Tomohide Tsukahara;Yuki Nabeta;Satoshi Kawaguchi;Hideyuki Ikeda

  • Ovarian Cancer Stem Cells Are Enriched in Side Population and Aldehyde Dehydrogenase Bright Overlapping Population

    Kazuyo Yasuda;Toshihiko Torigoe;Rena Morita;Takahumi Kuroda

Frequent Co-Authors

Toshihiko Torigoe
Toshihiko Torigoe Sapporo Medical University
Noriyuki Sato
Noriyuki Sato Sapporo Medical University
Koichi Hirata
Koichi Hirata Sapporo Medical University
Mark I. Greene
Mark I. Greene University of Pennsylvania
Takashi Tokino
Takashi Tokino Sapporo Medical University
Kohzoh Imai
Kohzoh Imai University of Tokyo
Hongtao Zhang
Hongtao Zhang University of Pennsylvania
Akiko Maeda
Akiko Maeda Case Western Reserve University
Minoru Toyota
Minoru Toyota Sapporo Medical University
Norimasa Sawada
Norimasa Sawada Sapporo Medical University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a degree in Biology or Biochemistry can open the door to many rewarding careers in healthcare and science. Increasingly, online programs have become popular, allowing students to gain specialized skills while maintaining flexibility. Some key pathways include medical coding, health information management, and nutrition.

For those interested in healthcare administration, becoming a medical coder is a viable option. This role involves translating patient data into standardized codes for billing and records, and a medical.coder salary can be competitive, especially with experience and certifications. Understanding the medical billing and coding job outlook is also crucial, as demand for these positions continues to grow alongside the healthcare industry.

For students seeking affordable pathways, consider affordable online him programs or the cheapest online nutrition degree options. These programs not only reduce financial strain but also prepare graduates for high-demand sectors in health data management and nutrition science.

Best Scientists Citing Yoshihiko Hirohashi

Trending Scientists

Recently Published Articles