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Medicine

D-Index
76
Citations
26173
World Ranking
18665
National Ranking
9301

Overview

James J. Hsieh is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions within the subfields of Pulmonary and Respiratory Medicine, Molecular Biology, Cancer Research, Oncology, and Surgery.

The scientist's research topics focus extensively on renal and related cancers, covering aspects related to renal cell carcinoma treatment, cancer genomics and diagnostics, cancer immunotherapy and biomarkers, bladder and urothelial cancer treatments, ferroptosis and cancer prognosis, and the roles of immune cells in cancer.

Some of their recent papers include:

  • Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma, 2021, New England Journal of Medicine
  • TGF-β suppresses type 2 immunity to cancer, 2020, Nature
  • Lenvatinib plus pembrolizumab in patients with either treatment-naive or previously treated metastatic renal cell carcinoma (Study 111/KEYNOTE-146): a phase 1b/2 study, 2021, The Lancet Oncology
  • Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness, 2022, Cancer Cell
  • Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer, 2022, Immunity

Frequent co-authors of James J. Hsieh include:

  • Yang Lyu
  • Robert J. Motzer
  • A. Ari Hakimi
  • Ravshan Ataullakhanov
  • Ekaterina Postovalova

The scientist commonly publishes in venues such as:

  • Clinical Genitourinary Cancer
  • Journal of Clinical Oncology
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Cell

This profile underscores James J. Hsieh's extensive involvement in research related to cancer biology and treatment, especially focused on renal cell carcinoma and its broader oncological context. Their collaborations and publication record reflect an active engagement in advancing knowledge in oncology through a multidisciplinary approach integrating molecular biology and clinical research.

Best Publications

  • Comprehensivemolecular characterization of clear cell renal cell carcinoma

    Chad J. Creighton;Margaret Morgan;Preethi H. Gunaratne;Preethi H. Gunaratne;David A. Wheeler

  • Renal cell carcinoma.

    James J. Hsieh;Mark P. Purdue;Sabina Signoretti;Charles Swanton

  • Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

    W. Marston Linehan;Paul T. Spellman;Christopher J. Ricketts;Chad J. Creighton

  • Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

    Toni K. Choueiri;Thomas Powles;Mauricio Burotto;Bernard Escudier

  • Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures

    Yasin Şenbabaoğlu;Ron S. Gejman;Ron S. Gejman;Andrew G. Winer;Ming Liu

  • The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

    Caleb F. Davis;Christopher J. Ricketts;Min Wang;Lixing Yang

  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

    Christopher J Ricketts;Aguirre A De Cubas;Huihui Fan;Christof C Smith

  • Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

    Samra Turajlic;Samra Turajlic;Hang Xu;Kevin Litchfield;Andrew Rowan

  • Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.

    David J. Clark;Saravana M. Dhanasekaran;Francesca Petralia;Jianbo Pan

  • Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

    Hyungjin Kim;Ho-Chou Tu;Decheng Ren;Osamu Takeuchi

  • An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

    A. Ari Hakimi;Ed Reznik;Chung Han Lee;Chad J. Creighton

  • Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2.

    J. J.-D. Hsieh;T. Henkel;P. Salmon;E. Robey

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

    Decheng Ren;Ho Chou Tu;Hyungjin Kim;Gary X. Wang

  • Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

    Carrie Shawber;Donna Nofziger;James J.D. Hsieh;Claire Lindsell

  • Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2

    J. J.-D. Hsieh;S. D. Hayward

  • Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.

    A Ari Hakimi;Irina Ostrovnaya;Boris A Reva;Nikolaus Schultz

  • Proteogenomic Characterization of Endometrial Carcinoma.

    Yongchao Dou;Emily A. Kawaler;Daniel Cui Zhou;Marina A. Gritsenko

  • SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.

    Sifang Zhou;Masahiro Fujimuro;James J.-D. Hsieh;Lin Chen

  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (vol 23, pg 313, 2018)

    Christopher J Ricketts;Aguirre A De Cubas;Huihui Fan;Christof C Smith

Frequent Co-Authors

Robert J. Motzer
Robert J. Motzer Memorial Sloan Kettering Cancer Center
Emily H. Cheng
Emily H. Cheng Memorial Sloan Kettering Cancer Center
Paul Russo
Paul Russo Memorial Sloan Kettering Cancer Center
Victor E. Reuter
Victor E. Reuter Memorial Sloan Kettering Cancer Center
Toni K. Choueiri
Toni K. Choueiri Harvard University
Chris Sander
Chris Sander Harvard University
Ed Reznik
Ed Reznik Memorial Sloan Kettering Cancer Center
Maria E. Arcila
Maria E. Arcila Memorial Sloan Kettering Cancer Center
Pheroze Tamboli
Pheroze Tamboli The University of Texas MD Anderson Cancer Center
Sabina Signoretti
Sabina Signoretti Brigham and Women's Hospital

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