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Biology and Biochemistry

D-Index
58
Citations
35507
World Ranking
12871
National Ranking
5476

Overview

Emily H. Cheng is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research spans biochemistry, genetics, molecular biology, and medicine, with key contributions in molecular biology, pulmonary and respiratory medicine, cancer research, pathology and forensic medicine, and immunology.

The main research topics covered by Cheng include:

  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Lung Cancer Treatments and Mutations
  • Ferroptosis and cancer prognosis
  • RNA modifications and cancer
  • Cell death mechanisms and regulation
  • Cancer Mechanisms and Therapy

Cheng frequently collaborates with several scientists:

  • James J. Hsieh
  • Elisa de Stanchina
  • Romel Somwar
  • Kota Ishizawa
  • Igor Odintsov

The research has been published repeatedly in several journals, reflecting areas of focus and expertise:

  • Nature Cancer
  • Cancer Cell
  • Nature Communications
  • JCI Insight
  • Cancer Research

Among recent publications authored or co-authored by Emily H. Cheng are:

  • Apoptotic cell death in disease-Current understanding of the NCCD 2023 (2023), published in Cell Death and Differentiation
  • Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis (2021), published in Cancer Cell
  • Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma (2020), published in Cancer Cell
  • Apoptosis in Cancer Biology and Therapy (2025), published in Annual Review of Pathology Mechanisms of Disease
  • SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes (2022), published in Nature Cancer

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

    Michael C. Wei;Michael C. Wei;Wei-Xing Zong;Emily H.-Y. Cheng;Tullia Lindsten

  • BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

    Emily H.-Y.A Cheng;Michael C Wei;Solly Weiler;Richard A Flavell

  • BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis

    Luca Scorrano;Scott A. Oakes;Joseph T. Opferman;Emily H. Cheng

  • Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

    Emily H.-Y. Cheng;Emily H.-Y. Cheng;David G. Kirsch;David G. Kirsch;Rollie J. Clem;Rollie J. Clem;Rajani Ravi;Rajani Ravi

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • VDAC2 inhibits BAK activation and mitochondrial apoptosis.

    Emily H.-Y. Cheng;Tatiana V. Sheiko;Jill K. Fisher;William J. Craigen

  • Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.

    Hyungjin Kim;Mubina Rafiuddin-Shah;Ho-Chou Tu;John R. Jeffers

  • Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures

    Yasin Şenbabaoğlu;Ron S. Gejman;Ron S. Gejman;Andrew G. Winer;Ming Liu

  • BAX activation is initiated at a novel interaction site

    Evripidis Gavathiotis;Motoshi Suzuki;Marguerite L. Davis;Marguerite L. Davis;Kenneth L. Pitter;Kenneth L. Pitter

  • Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

    Hyungjin Kim;Ho-Chou Tu;Decheng Ren;Osamu Takeuchi

  • Modulation of cell death by Bcl-XL through caspase interaction.

    Rollie J. Clem;Rollie J. Clem;Emily H.-Y. Cheng;Emily H.-Y. Cheng;Christopher L. Karp;David G. Kirsch

  • An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

    A. Ari Hakimi;Ed Reznik;Chung Han Lee;Chad J. Creighton

  • Bax-independent inhibition of apoptosis by Bcl-XL

    Emily H Y Cheng;Beth Levine;Lawrence H. Boise;Craig B. Thompson

  • A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

    Emily H.Y. Cheng;John Nicholas;David S. Bellows;Gary S. Hayward

  • BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

    Decheng Ren;Ho Chou Tu;Hyungjin Kim;Gary X. Wang

  • Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion

    Ji Zhang;Jing Fan;Sriram Venneti;Justin R. Cross

  • Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.

    A Ari Hakimi;Irina Ostrovnaya;Boris A Reva;Nikolaus Schultz

  • A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast.

    Evgeny V. Pavlov;Muriel Priault;Dawn Pietkiewicz;Emily H.-Y. Cheng

  • Taspase1: A Threonine Aspartase Required for Cleavage of MLL and Proper HOX Gene Expression

    James J.-D. Hsieh;Emily H.-Y. Cheng;Stanley J. Korsmeyer

Frequent Co-Authors

James J. Hsieh
James J. Hsieh Washington University in St. Louis
Paul Russo
Paul Russo Memorial Sloan Kettering Cancer Center
Robert J. Motzer
Robert J. Motzer Memorial Sloan Kettering Cancer Center
Victor E. Reuter
Victor E. Reuter Memorial Sloan Kettering Cancer Center
Chris Sander
Chris Sander Harvard University
J. Marie Hardwick
J. Marie Hardwick Johns Hopkins University
Chad J. Creighton
Chad J. Creighton Baylor College of Medicine
Satish K. Tickoo
Satish K. Tickoo Memorial Sloan Kettering Cancer Center
David P. Kelsen
David P. Kelsen Memorial Sloan Kettering Cancer Center
Nikolaus Schultz
Nikolaus Schultz Memorial Sloan Kettering Cancer Center

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