Clifford C. Taggart

Overview

Best Publications

• Oxidation of either methionine 351 or Methionine 358 in alpha-1-Antitrypsin causes loss of anti-neutrophil elastase activity

  Clifford Taggart;Daniel Cervantes-Laurean;Geumsoo Kim;Noel G. McElvaney

  401
  Citations

• Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers

  Murali Shyamsundar;Scott T. W. McKeown;Cecilia M. O'Kane;Thelma R. Craig

  305
  Citations

• Secretory leucoprotease inhibitor binds to NF-κB binding sites in monocytes and inhibits p65 binding

  Clifford C. Taggart;Sally Ann Cryan;Sinead Weldon;Aileen Gibbons

  287
  Citations

• TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells.

  Catherine M. Greene;Tomás P. Carroll;Stephen G. J. Smith;Clifford C. Taggart

  285
  Citations

• Neutrophil elastase up‐regulates interleukin‐8 via toll‐like receptor 4

  James M Devaney;Catherine M Greene;Clifford C Taggart;Tomás P Carroll

  280
  Citations

• Inactivation of Human β-Defensins 2 and 3 by Elastolytic Cathepsins

  Clifford C. Taggart;Catherine M. Greene;Stephen G. Smith;Rodney L. Levine

  260
  Citations

• Cathepsin B, L, and S Cleave and Inactivate Secretory Leucoprotease Inhibitor

  Clifford C. Taggart;Gregory J. Lowe;Catherine M. Greene;Alan T. Mulgrew

  223
  Citations

• Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.

  Matthew W. Lawless;Catherine M. Greene;Alan Mulgrew;Clifford C. Taggart

  207
  Citations

• Loss of Microbicidal Activity and Increased Formation of Biofilm Due to Decreased Lactoferrin Activity in Patients with Cystic Fibrosis

  Mark P. Rogan;Clifford C. Taggart;Catherine M. Greene;Philip G. Murphy

  195
  Citations

• Interleukin-8 Up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human Bronchial Epithelium

  Deirdre E. Walsh;Catherine M. Greene;Tomás P. Carroll;Clifford C. Taggart

  195
  Citations

• Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: formulation, characterisation and functionalisation with dornase alfa (DNase).

  Jill Deacon;Sharif M. Abdelghany;Derek J. Quinn;Daniela Schmid

  192
  Citations

• Z α1-Antitrypsin Polymerizes in the Lung and Acts as a Neutrophil Chemoattractant

  Alan T. Mulgrew;Clifford C. Taggart;Matthew W. Lawless;Catherine M. Greene

  190
  Citations

• Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection.

  Sharif M Abdelghany;Derek J Quinn;Rebecca J Ingram;Brendan F Gilmore

  190
  Citations

• Secretory Leucoprotease Inhibitor Prevents Lipopolysaccharide-induced IκBα Degradation without Affecting Phosphorylation or Ubiquitination

  Clifford C Taggart;Catherine M Greene;Noel G McElvaney;Shane J O'Neill

  189
  Citations

• Antimicrobial proteins and polypeptides in pulmonary innate defence

  Mark P Rogan;Patrick Geraghty;Catherine M Greene;Shane J O'Neill

  187
  Citations

• Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-α and interleukin-8

  Clifford Taggart;Raymond J. Coakley;Peter Greally;Gerry Canny

  158
  Citations

• Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation

  Sinéad Weldon;Paul McNally;Noel G. McElvaney;J. Stuart Elborn

  150
  Citations

• Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide

  Ruth E MacRedmond;Catherine M Greene;Clifford C Taggart;Noel G McElvaney

  146
  Citations

• Activation of the Epidermal Growth Factor Receptor (EGFR) by a Novel Metalloprotease Pathway

  David A. Bergin;Catherine M. Greene;Erwin E. Sterchi;Cliona Kenna

  142
  Citations

• Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis

  Raymond J. Coakley;Clifford Taggart;Noel G. McElvaney;Shane J. O'Neill

  139
  Citations