World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
103
Citations
41265
World Ranking
7330
National Ranking
3838

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Jeffrey E. Saffitz is affiliated with the Beth Israel Deaconess Medical Center in the United States. Their research primarily focuses on medicine, with a concentration on cardiology and cardiovascular medicine, orthopedics and sports medicine, surgery, molecular biology, and complementary and alternative medicine.

The main topics of their work include:

  • Cardiovascular Effects of Exercise
  • Sports injuries and prevention
  • Viral Infections and Immunology Research
  • Cardiac electrophysiology and arrhythmias
  • Cardiomyopathy and Myosin Studies
  • Cardiovascular and exercise physiology
  • Cardiac Structural Anomalies and Repair

Some of Jeffrey E. Saffitz's recent papers feature the following:

  • Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy, 2021, Science Translational Medicine
  • CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress, 2020, Circulation Research
  • Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC, 2021, Journal of Clinical Medicine
  • GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy, 2023, Circulation Research
  • NFĸB signaling drives myocardial injury via CCR2+ macrophages in a preclinical model of arrhythmogenic cardiomyopathy, 2024, Journal of Clinical Investigation

The scientist's frequent co-authors include:

  • Stephen P. Chelko
  • Vinay Penna
  • Angeliki Asimaki
  • Morgan Engel
  • Kory J. Lavine

Jeffrey E. Saffitz has published extensively in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Heart Rhythm
  • Circulation
  • Journal of Clinical Investigation
  • Circulation Arrhythmia and Electrophysiology

Throughout their career, Saffitz has focused research efforts on cardiomyopathies, arrhythmias, and the effects of exercise on cardiovascular physiology, contributing to an understanding of molecular and immunologic mechanisms underlying these conditions.

An award associated with the scientist includes membership in the Association of American Physicians.

Best Publications

  • Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia Proposed Modification of the Task Force Criteria

    Frank I. Marcus;William J. McKenna;Duane Sherrill;Cristina Basso

  • Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia

    Frank I. Marcus;William J. McKenna;Duane Sherrill;Cristina Basso

  • Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

    John J. Lehman;Philip M. Barger;Attila Kovacs;Jeffrey E. Saffitz

  • PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

    Teresa C Leone;John J Lehman;Brian N Finck;Paul J Schaeffer

  • A novel mouse model of lipotoxic cardiomyopathy.

    Hsiu-Chiang Chiu;Attila Kovacs;David A. Ford;Fong-Fu Hsu

  • 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy

    Jeffrey A. Towbin;William J. McKenna;Dominic J. Abrams;Michael J. Ackerman

  • The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart.

    C Antzelevitch;W Shimizu;G X Yan;S Sicouri

  • Dephosphorylation and Intracellular Redistribution of Ventricular Connexin43 During Electrical Uncoupling Induced by Ischemia

    Michael A. Beardslee;Deborah L. Lerner;Peter N. Tadros;James G. Laing

  • Evidence for Cardiomyocyte Repopulation by Extracardiac Progenitors in Transplanted Human Hearts

    Michael A. Laflamme;David Myerson;Jeffrey E. Saffitz;Charles E. Murry

  • A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

    Fatima Djouadi;Carla J. Weinheimer;Jeffrey E. Saffitz;Clovis Pitchford

  • Rapid Turnover of Connexin43 in the Adult Rat Heart

    Michael A. Beardslee;James G. Laing;Eric C. Beyer;Jeffrey E. Saffitz

  • 2011 Consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology

    Ornella Leone;John P. Veinot;Annalisa Angelini;Ulrik T. Baandrup

  • Cardiac-Specific Induction of the Transcriptional Coactivator Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Promotes Mitochondrial Biogenesis and Reversible Cardiomyopathy in a Developmental Stage-Dependent Manner

    Laurie K. Russell;Carolyn M. Mansfield;John J. Lehman;Attila Kovacs

  • Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: Evidence supporting the concept of arrhythmogenic cardiomyopathy

    Paul A. van der Zwaag;Ingrid A. W. van Rijsingen;Angeliki Asimaki;Jan D. H. Jongbloed

  • A New Diagnostic Test for Arrhythmogenic Right Ventricular Cardiomyopathy

    Angeliki Asimaki;Harikrishna Tandri;Hayden Huang;Marc K. Halushka

  • The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.

    Pu Liao;Dimitrios Georgakopoulos;Attila Kovacs;Meizi Zheng

  • Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease)

    Starr R Kaplan;Joseph J Gard;Nikos Protonotarios;Adalena Tsatsopoulou

  • Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium.

    J E Saffitz;H L Kanter;K G Green;T K Tolley

  • Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

    Ronald J. Diebold;Michael J. Eis;Moying Yin;Ilona Ormsby

  • A New Diagnostic Test For Arrhythmogenic Right Ventricular Cardiomyopathy

    A Asimaki;H Tandri;H Huang;M Halushka

Frequent Co-Authors

Richard B. Schuessler
Richard B. Schuessler Washington University in St. Louis
Eric C. Beyer
Eric C. Beyer University of Chicago
Hugh Calkins
Hugh Calkins Johns Hopkins University
William J. McKenna
William J. McKenna University College London
Gaetano Thiene
Gaetano Thiene University of Padua
Burton E. Sobel
Burton E. Sobel Washington University in St. Louis
Daniel P. Judge
Daniel P. Judge Medical University of South Carolina
Cristina Basso
Cristina Basso University of Padua
Thomas L. Spray
Thomas L. Spray Children's Hospital of Philadelphia
Calum A. MacRae
Calum A. MacRae Brigham and Women's Hospital

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