World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
19657
World Ranking
17403
National Ranking
608

Overview

Gerald D. Gish is affiliated with the Lunenfeld-Tanenbaum Research Institute in Canada and has contributed to research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work encompasses various subfields including Molecular Biology, Cell Biology, Cardiology and Cardiovascular Medicine, Spectroscopy, and Pathology and Forensic Medicine.

The scientist's research topics cover Protein Structure and Dynamics, RNA Research and Splicing, RNA and protein synthesis mechanisms, Fungal and yeast genetics research, Bioinformatics and Genomic Networks, RNA regulation and disease, and Viral Infections and Immunology Research.

Among recent publications, notable papers include:

  • Protein context shapes the specificity of SH3 domain-mediated interactions in vivo, 2021, Nature Communications
  • A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency, 2020, Proceedings of the National Academy of Sciences
  • Engineered SH2 Domains for Targeted Phosphoproteomics, 2022, ACS Chemical Biology
  • The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma, 2023, Cancers
  • The Shb scaffold binds the Nck adaptor protein, p120 RasGAP, and Chimaerins and thereby facilitates heterotypic cell segregation by the receptor EphB2, 2020, Journal of Biological Chemistry

The scientist has published in several frequently appearing venues, including:

  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • ACS Chemical Biology
  • Cancers
  • Structure

Collaborative efforts have featured frequent co-authors such as Frank Sicheri, Ugo Dionne, Émilie Bourgault, Alexandre K. Dubé, and David Bradley. These partnerships have contributed to advancing research within their primary scientific areas.

Best Publications

  • SH2 domains recognize specific phosphopeptide sequences

    Songyang Zhou;Songyang Zhou;Steven E. Shoelson;Manas Chaudhuri;Gerald Gish

  • Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation

    Neil A. Farrow;Ranjith Muhandiram;Alex U. Singer;Steven M. Pascal

  • SH2 and SH3 domains: From structure to function

    Tony Pawson;Gerald D. Gish

  • The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen

    Wolfgang Vogel;Gerald D Gish;Frauke Alves;Tony Pawson;Tony Pawson

  • The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

    Robert J Ingham;Gerald Gish;Tony Pawson;Tony Pawson

  • Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

    Lorri Puil;Jiaxin Liu;Gerald Gish;Geraldine Mbamalu

  • SH2 domains, interaction modules and cellular wiring.

    Tony Pawson;Gerald D Gish;Piers Nash

  • Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells.

    Samantha Gruenheid;Rebekah DeVinney;Rebekah DeVinney;Friedhelm Bladt;Danika Goosney

  • A Rich1/Amot Complex Regulates the Cdc42 GTPase and Apical-Polarity Proteins in Epithelial Cells

    Clark D. Wells;James P. Fawcett;Andreas Traweger;Yojiro Yamanaka

  • Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype

    Tilo Kunath;Gerald Gish;Heiko Lickert;Nina Jones

  • The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif.

    Dan Lin;Gerald D. Gish;Zhou Songyang;Tony Pawson;Tony Pawson

  • Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

    Sacha J. Holland;Nicholas W. Gale;Gerald D. Gish;Richard A. Roth

  • Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

    Sylvain Latour;Sylvain Latour;Gerald Gish;Cheryl D. Helgason;R. Keith Humphries

  • Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.

    Steven M. Pascal;Alex U. Singer;Gerry Gish;Toshio Yamazaki

  • WW domains provide a platform for the assembly of multiprotein networks.

    Robert J. Ingham;Karen Colwill;Caley Howard;Sabine Dettwiler

  • The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions.

    Peter van der Geer;Sandra Wiley;Gerald D. Gish;Tony Pawson

  • SRPK1 and Clk/Sty Protein Kinases Show Distinct Substrate Specificities for Serine/Arginine-rich Splicing Factors

    Karen Colwill;Karen Colwill;Lana L. Feng;Joanne.M. Yeakley;Gerald D. Gish

  • SH2 domain specificity and activity modified by a single residue

    Luc E. M. Marengere;Luc E. M. Marengere;Zhou Songyang;Gerald D. Gish;Michael D. Schaller

  • Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

    Sebastian Guettler;Sebastian Guettler;Jose LaRose;Evangelia Petsalaki;Evangelia Petsalaki;Gerald Gish

  • SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

    Dorothy Yanling Zhao;Dorothy Yanling Zhao;Gerald Gish;Ulrich Braunschweig;Yue Li

Frequent Co-Authors

Tony Pawson
Tony Pawson University of Toronto
Frank Sicheri
Frank Sicheri Lunenfeld-Tanenbaum Research Institute
Robert Rottapel
Robert Rottapel University of Toronto
Ingemar Ernberg
Ingemar Ernberg Karolinska Institute
Lewis E. Kay
Lewis E. Kay University of Toronto
Lewis C. Cantley
Lewis C. Cantley Harvard University
Christian R. Landry
Christian R. Landry Université Laval
Jinrong Min
Jinrong Min Structural Genomics Consortium
Mark Henkemeyer
Mark Henkemeyer The University of Texas Southwestern Medical Center
Janet Rossant
Janet Rossant University of Toronto

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