What is he best known for?
The fields of study he is best known for:
His primary areas of study are Genetics, Cell biology, Huntingtin, Polyglutamine tract and Neurodegeneration.
His Cell biology study frequently links to related topics such as Ataxin 1.
He works mostly in the field of Huntingtin, limiting it down to concerns involving Molecular biology and, occasionally, Gene expression, Tetratricopeptide, Chaperone and Nuclear protein.
He has included themes like Spinocerebellar Ataxia Type 1, Genetic screen and Protein–protein interaction in his Polyglutamine tract study.
His Neurodegeneration study frequently intersects with other fields, such as Ubiquitin ligase.
His Huntingtin Protein research includes themes of Cerebral cortex and Proteomics.
His most cited work include:
- Identification of genes that modify ataxin-1-induced neurodegeneration (581 citations)
- Interaction of Akt-Phosphorylated Ataxin-1 with 14-3-3 Mediates Neurodegeneration in Spinocerebellar Ataxia Type 1 (369 citations)
- Huntingtin interacting proteins are genetic modifiers of neurodegeneration. (344 citations)
What are the main themes of his work throughout his whole career to date?
Juan Botas spends much of his time researching Cell biology, Genetics, Neurodegeneration, Huntingtin and Neuroscience.
The concepts of his Cell biology study are interwoven with issues in Alpha-synuclein, Trinucleotide repeat expansion, Regulation of gene expression and Nuclear protein, Ataxin 1.
The study incorporates disciplines such as Spinocerebellar Ataxia Type 1 and Spinocerebellar ataxia in addition to Ataxin 1.
His study in Neurodegeneration is interdisciplinary in nature, drawing from both Alzheimer's disease, Gene knockdown, Chaperone and Genetic screen.
His Huntingtin study incorporates themes from Molecular biology, Gene expression and DNA damage.
His study looks at the intersection of Neuroscience and topics like Disease with Computational biology.
He most often published in these fields:
- Cell biology (60.44%)
- Genetics (46.15%)
- Neurodegeneration (41.76%)
What were the highlights of his more recent work (between 2016-2021)?
- Neurodegeneration (41.76%)
- Spinocerebellar Ataxia Type 1 (20.88%)
- Ataxin 1 (24.18%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Neurodegeneration, Spinocerebellar Ataxia Type 1, Ataxin 1, Cell biology and Disease.
His Neurodegeneration study frequently draws parallels with other fields, such as Gene.
His Spinocerebellar Ataxia Type 1 study combines topics from a wide range of disciplines, such as Kinase and Genetic screen.
His research on Cell biology often connects related topics like Huntingtin.
His work is dedicated to discovering how Disease, Computational biology are connected with RNA interference, Druggability, Small hairpin RNA, Genome and Copy-number variation and other disciplines.
His research investigates the connection with Apolipoprotein E and areas like Genetics which intersect with concerns in Evolutionary information.
Between 2016 and 2021, his most popular works were:
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) (38 citations)
- A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach. (18 citations)
- A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach. (18 citations)
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