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Neuroscience

D-Index
55
Citations
9473
World Ranking
4775
National Ranking
2148

Overview

James E. Zadina is affiliated with Tulane University in the United States and has contributed to the fields of neuroscience and medicine through several research publications. Their main focus is on cellular and molecular neuroscience, with additional work in physiology, pharmacology, reproductive medicine, and molecular biology.

Zadina's research primarily addresses neuropeptides and animal physiology, pain mechanisms and treatments, neurotransmitter receptor influence on behavior, pharmacological effects of natural compounds, hypothalamic control of reproductive hormones, and biochemical and structural characterization.

Recent papers authored or coauthored by Zadina include:

  • "Endomorphin analog ZH853 shows low reward, tolerance, and affective-motivational signs of withdrawal, while inhibiting opioid withdrawal and seeking", 2023, Neuropharmacology
  • "Comparison of Morphine and Endomorphin Analog ZH853 for Tolerance and Immunomodulation in a Rat Model of Neuropathic Pain", 2024, Journal of Pain
  • "Cyclic Glycopeptide Analogs of Endomorphin-1 Provide Highly Effective Antinociception in Male and Female Mice", 2024, ACS Medicinal Chemistry Letters

Zadina's frequent coauthors include Leticia Ferreira Nakatani, Ariel T. Amgott-Kwan, Terrence J. Hunter, Zoe M Videlefsky, and Lajos Szabó.

Their research has been published in venues such as:

  • Neuropharmacology
  • Journal of Pain
  • ACS Medicinal Chemistry Letters

Best Publications

  • A potent and selective endogenous agonist for the µ-opiate receptor

    Unknown

  • Differential distribution of endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent.

    Sheryl Martin-Schild;Arnold A. Gerall;Abba J. Kastin;Abba J. Kastin;James E. Zadina;James E. Zadina

  • Opiate tolerance and dependence: receptors, G-proteins, and antiopiates

    Laura M Harrison;Abba J Kastin;James E Zadina

  • Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models.

    Adam Stewart;Nadine Wu;Jonathan Cachat;Peter Hart

  • Isolation of Relatively Large Amounts of Endomorphin-1 and Endomorphin-2 From Human Brain Cortex

    Laszlo Hackler;James E Zadina;Lin-Jun Ge;Abba J Kastin

  • Tumor Necrosis Factor-α: a Neuromodulator in the CNS

    Weihong Pan;James E Zadina;Richard E Harlan;Joseph T Weber

  • Chronic corticosterone impairs memory performance in the Barnes maze.

    Robert N McLay;Scott M Freeman;James E Zadina;James E Zadina

  • The neurotrophins and their receptors: Structure, function, and neuropathology

    Lawrence M. Maness;Lawrence M. Maness;Abba J. Kastin;Abba J. Kastin;Joseph T. Weber;Joseph T. Weber;William A. Banks;William A. Banks

  • Localization of endomorphin-2-like immunoreactivity in the rat medulla and spinal cord.

    Sheryl Martin-Schild;James E Zadina;Arnold A Gerall;Sandor Vigh

  • Endomorphins: novel endogenous mu-opiate receptor agonists in regions of high mu-opiate receptor density.

    James E. Zadina;James E. Zadina;Sheryl Martin-Schild;Arnold A. Gerall;Abba J. Kastin;Abba J. Kastin

  • Rewarding and Psychomotor Stimulant Effects of Endomorphin-1: Anteroposterior Differences within the Ventral Tegmental Area and Lack of Effect in Nucleus Accumbens

    Abraham Zangen;Satoshi Ikemoto;James E. Zadina;Roy A. Wise

  • Differential Cardiorespiratory Effects of Endomorphin 1, Endomorphin 2, DAMGO, and Morphine

    Marc A. Czapla;David Gozal;Oscar A. Alea;Robert C. Beckerman

  • Differential involvement of μ-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception

    Shinobu Sakurada;James E Zadina;Abba J Kastin;Sou Katsuyama

  • Endomorphin-2 is an endogenous opioid in primary sensory afferent fibers

    Sheryl Martin-Schild;Arnold A. Gerall;Abba J. Kastin;Abba J. Kastin;James E. Zadina;James E. Zadina

  • Dissociation of analgesic and rewarding effects of endomorphin-1 in rats

    Aimee M Wilson;R.Denis Soignier;James E Zadina;James E Zadina;Abba J Kastin;Abba J Kastin;Abba J Kastin

  • Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum

    James E. Zadina;Abba J. Kastin;Douglas Kersh;Allan Wyatt

  • Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine.

    James E. Zadina;Mark R. Nilges;Jenny Morgenweck;Xing Zhang

  • Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse

    Shinobu Sakurada;Takafumi Hayashi;Masayuki Yuhki;Tohru Orito

  • Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1)

    Judit Erchegyi;Judit Erchegyi;Abba J. Kastin;Abba J. Kastin;James E. Zadina;James E. Zadina

  • Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone.

    Shinobu Sakurada;Takafumi Hayashi;Masayuki Yuhki;Tsutomu Fujimura

  • Characterization of binding sites for N-Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) in rat brain

    James E. Zadina;Abba J. Kastin;Edward F. Krieg;David H. Coy

  • Endomorphin 1 and 2, Endogenous Ligands for the μ-opioid Receptor, Decrease Cardiac Output, and Total Peripheral Resistance in the Rat

    Hunter C Champion;James E Zadina;James E Zadina;Abba J Kastin;Abba J Kastin;Laszlo Hackler;Laszlo Hackler

Frequent Co-Authors

Bradley K. Taylor
Bradley K. Taylor University of Pittsburgh
Tsukasa Sakurada
Tsukasa Sakurada Daiichi University of Pharmacy
H. Elliott Albers
H. Elliott Albers Georgia State University
Shinobu Sakurada
Shinobu Sakurada Tohoku Medical and Pharmaceutical University
Sue A. Aicher
Sue A. Aicher Oregon Health & Science University
Abraham Zangen
Abraham Zangen Ben-Gurion University of the Negev
Roy A. Wise
Roy A. Wise National Institute on Drug Abuse
Kim L. Huhman
Kim L. Huhman Georgia State University
Grace C. Rossi
Grace C. Rossi Long Island University
Jun Lu
Jun Lu Zhejiang University

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