World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
16410
World Ranking
14196
National Ranking
70

Research.com Recognitions

  • Member of the Norwegian Academy of Science and Letters Biochemistry, Biophysics, and Molecular Biology
  • Member of the Norwegian Academy of Science and Letters Biochemistry, Biophysics, and Molecular Biology
  • Member of the Norwegian Academy of Science and Letters Biochemistry, Biophysics, and Molecular Biology

Overview

Geir Slupphaug is affiliated with the Norwegian University of Science and Technology in Norway. Their research spans multiple intersecting fields within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology and cancer-related studies. The scientist's work often emphasizes mechanisms of DNA repair, RNA modifications, and epigenetic regulation.

The main topics addressed in their research include:

  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • DNA Repair Mechanisms
  • Cancer-related gene regulation
  • RNA and protein synthesis mechanisms
  • Cytomegalovirus and herpesvirus research
  • Histone Deacetylase Inhibitors Research

Within their publication record, significant venues where their work has appeared multiple times are:

  • Journal of Translational Medicine
  • Materials Today Bio
  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal for ImmunoTherapy of Cancer

Frequent co-authors collaborating with Slupphaug include:

  • Lars Hagen
  • Animesh Sharma
  • Anna Kuśnierczyk
  • Cathrine Broberg Vågbø
  • Tobias S. Iveland

Their notable recent papers provide insight into the specific research topics addressed:

  • Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade, 2020, Journal for ImmunoTherapy of Cancer
  • Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN, 2020, Molecular Metabolism
  • Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation, 2024, Nature Communications
  • RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork, 2021, Nucleic Acids Research
  • ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA, 2021, Journal of Translational Medicine

Geir Slupphaug's research is grounded in understanding molecular mechanisms central to cancer biology and DNA repair processes. Their studies address epigenetic modifications, enzymatic functions in nucleic acid metabolism, and the cellular responses to DNA damage and stress.

Recognition of their contributions includes election as a Member of the Norwegian Academy of Science and Letters in the category of Biochemistry, Biophysics, and Molecular Biology.

Best Publications

  • DNA glycosylases in the base excision repair of DNA.

    Hans E. Krokan;Rune Standal;Geir Slupphaug

  • Alkylation damage in DNA and RNA--repair mechanisms and medical significance.

    Finn Drabløs;Emadoldin Feyzi;Per Arne Aas;Cathrine B. Vaagbø

  • Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.

    Kohsuke Imai;Geir Slupphaug;Wen I. Lee;Wen I. Lee;Patrick Revy

  • Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

    Per Arne Aas;Marit Otterlei;Pål Ø. Falnes;Cathrine B. Vågbø

  • The interacting pathways for prevention and repair of oxidative DNA damage.

    Geir Slupphaug;Bodil Kavli;Hans E Krokan

  • A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.

    Geir Slupphaug;Clifford D. Mol;Bodil Kavli;Andrew S. Arvai

  • Uracil in DNA – occurrence, consequences and repair

    Hans E Krokan;Finn Drabløs;Geir Slupphaug

  • Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

    Sudip S. Parikh;Clifford D. Mol;Geir Slupphaug;Sangeeta Bharati

  • Base excision repair of DNA in mammalian cells

    Hans E Krokan;Hilde Nilsen;Frank Skorpen;Marit Otterlei

  • Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.

    Clifford D Mol;Andrew S Arvai;Geir Slupphaug;Bodil Kavli

  • Post-replicative base excision repair in replication foci.

    Marit Otterlei;Emma Warbrick;Toril A. Nagelhus;Terje Haug

  • hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.

    Bodil Kavli;Ottar Sundheim;Mansour Akbari;Marit Otterlei

  • Uracil-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication

    Hilde Nilsen;Hilde Nilsen;Ian Rosewell;Peter Robins;Camilla F Skjelbred

  • Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

    Monica D. Bjørge;Gunn A. Hildrestrand;Katja Scheffler;Katja Scheffler;Rajikala Suganthan

  • Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: Protein mimicry of DNA

    Clifford D Mol;Andrew S Arvai;Russell J Sanderson;Geir Slupphaug

  • Uracil-DNA glycosylase–DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

    Sudip S. Parikh;Gunter Walcher;Garry D. Jones;Geir Slupphaug

  • Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.

    Geir Slupphaug;Ingrid Eftedal;Bodil Kavli;Sangeeta Bharati

  • GLUCOCORTICOIDS INHIBIT THE PRODUCTION OF IL6 FROM MONOCYTES, ENDOTHELIAL CELLS AND FIBROBLASTS

    Anders Waage;Geir Slupphaug;Refaat Shalaby

  • Human Immunodeficiency Virus Type 1 Vpr Protein Binds to the Uracil DNA Glycosylase DNA Repair Enzyme

    Mohamad Bouhamdan;S. Benichou;F. Rey;J.-M. Navarro

  • Cell cycle regulation of human DNA repair and chromatin remodeling genes

    Robin Mjelle;Siv Anita Hegre;Per Arne Aas;Geir Slupphaug

Frequent Co-Authors

Hans E. Krokan
Hans E. Krokan Norwegian University of Science and Technology
Magnar Bjørås
Magnar Bjørås Norwegian University of Science and Technology
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Andrew S. Arvai
Andrew S. Arvai Scripps Research Institute
Ulrik Wisløff
Ulrik Wisløff Norwegian University of Science and Technology
Pål Aukrust
Pål Aukrust Oslo University Hospital
Bente Halvorsen
Bente Halvorsen University of Oslo
Arne Klungland
Arne Klungland Oslo University Hospital
Anders Waage
Anders Waage Norwegian University of Science and Technology

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