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Molecular Biology
Norway
2026

D-Index & Metrics

Molecular Biology

D-Index
80
Citations
30795
World Ranking
985
National Ranking
3

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Norway Leader Award
  • 2025 - Research.com Molecular Biology in Norway Leader Award
  • 2023 - Research.com Molecular Biology in Norway Leader Award
  • Member of the Norwegian Academy of Science and Letters Biochemistry, Biophysics, and Molecular Biology
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the Norwegian Academy of Science and Letters Biochemistry, Biophysics, and Molecular Biology
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Hans E. Krokan is affiliated with the Norwegian University of Science and Technology in Norway. Their research spans multiple disciplines within biochemistry, genetics, and molecular biology, with contributions also in medicine.

Their primary fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, Krokan has focused on several subfields such as molecular biology, oncology, hematology, genetics, and parasitology.

The main research topics covered by Krokan consist of:

  • DNA Repair Mechanisms
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Acute Myeloid Leukemia Research
  • PARP inhibition in cancer therapy
  • CRISPR and Genetic Engineering
  • Single-cell and spatial transcriptomics

Some of Krokan's recent publications include:

  • Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress, 2022, Nature Cancer
  • Targeting OGG1 arrests cancer cell proliferation by inducing replication stress, 2020, Nucleic Acids Research
  • Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication, 2020, Science Advances
  • TiSA: TimeSeriesAnalysis-a pipeline for the analysis of longitudinal transcriptomics data, 2023, NAR Genomics and Bioinformatics
  • Genomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignancies, 2021, International Journal of Molecular Sciences

Krokan has collaborated frequently with several researchers including Antonio Sarno, Elisée Wiita, Camilla Göktürk, Therese Pham, and Ann-Sofie Jemth.

Their work has been published in prominent scientific journals such as Nature Cancer, Nucleic Acids Research, NAR Genomics and Bioinformatics, Science Advances, and the International Journal of Molecular Sciences.

In recognition of their contributions to science, Hans E. Krokan has been named a member of the Norwegian Academy of Science and Letters in the fields of biochemistry, biophysics, and molecular biology. They are also a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

    Guanqun Zheng;John Arne Dahl;Yamei Niu;Peter Fedorcsak

  • A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

    Rayjean J. Hung;James D. Mckay;Valerie Gaborieau;Paolo Boffetta

  • Base Excision Repair

    Hans E. Krokan;Magnar Bjørås

  • DNA glycosylases in the base excision repair of DNA.

    Hans E. Krokan;Rune Standal;Geir Slupphaug

  • Alkylation damage in DNA and RNA--repair mechanisms and medical significance.

    Finn Drabløs;Emadoldin Feyzi;Per Arne Aas;Cathrine B. Vaagbø

  • Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.

    Kohsuke Imai;Geir Slupphaug;Wen I. Lee;Wen I. Lee;Patrick Revy

  • Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

    Per Arne Aas;Marit Otterlei;Pål Ø. Falnes;Cathrine B. Vågbø

  • The interacting pathways for prevention and repair of oxidative DNA damage.

    Geir Slupphaug;Bodil Kavli;Hans E Krokan

  • A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.

    Geir Slupphaug;Clifford D. Mol;Bodil Kavli;Andrew S. Arvai

  • Lung cancer susceptibility locus at 5p15.33

    James D McKay;Rayjean J Hung;Rayjean J Hung;Valerie Gaborieau;Paolo Boffetta

  • Uracil in DNA – occurrence, consequences and repair

    Hans E Krokan;Finn Drabløs;Geir Slupphaug

  • A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma.

    Maria Teresa Landi;Nilanjan Chatterjee;Kai Yu;Lynn R. Goldin

  • Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

    Sudip S. Parikh;Clifford D. Mol;Geir Slupphaug;Sangeeta Bharati

  • Base excision repair of DNA in mammalian cells

    Hans E Krokan;Hilde Nilsen;Frank Skorpen;Marit Otterlei

  • Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.

    Clifford D Mol;Andrew S Arvai;Geir Slupphaug;Bodil Kavli

  • Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

    Yufei Wang;James D McKay;Thorunn Rafnar;Zhaoming Wang

  • The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease.

    P Klepstad;T T Rakvåg;S Kaasa;M Holthe

  • Post-replicative base excision repair in replication foci.

    Marit Otterlei;Emma Warbrick;Toril A. Nagelhus;Terje Haug

  • The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients.

    Trude Teoline Rakvåg;Pål Klepstad;Cecilie Baar;Tor-Morten Kvam

  • hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.

    Bodil Kavli;Ottar Sundheim;Mansour Akbari;Marit Otterlei

Frequent Co-Authors

Geir Slupphaug
Geir Slupphaug Norwegian University of Science and Technology
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Mark Lathrop
Mark Lathrop McGill University
Lars J. Vatten
Lars J. Vatten Norwegian University of Science and Technology
Rayjean J. Hung
Rayjean J. Hung Lunenfeld-Tanenbaum Research Institute
Paul Brennan
Paul Brennan International Agency For Research On Cancer
Arne Klungland
Arne Klungland Oslo University Hospital
John K. Field
John K. Field University of Liverpool
James McKay
James McKay International Agency For Research On Cancer
Chu Chen
Chu Chen Fred Hutchinson Cancer Research Center

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