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Biology and Biochemistry

D-Index
69
Citations
15671
World Ranking
7458
National Ranking
3399

Overview

Kristoffer Valerie is affiliated with Virginia Commonwealth University in the United States. Their research contributions primarily span the fields of Biochemistry, Genetics and Molecular Biology, and Medicine.

Their subfields of study include Molecular Biology, Cancer Research, Genetics, Neurology, and Pulmonary and Respiratory Medicine. Valerie's work focuses on several specialized topics such as DNA Repair Mechanisms, Glioma Diagnosis and Treatment, Cancer, Hypoxia, and Metabolism, Neuroblastoma Research and Treatments, Cancer therapeutics and mechanisms, as well as Radiation Therapy and Dosimetry, including Advanced Radiotherapy Techniques.

Recent publications authored or co-authored by Valerie include the following:

  • Adamantinomatous Craniopharyngioma in an Adult: A Case Report with NGS Analysis, 2020, International Medical Case Reports Journal
  • ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response, 2022, Cellular and Molecular Life Sciences
  • PEAMOtecan, a novel chronotherapeutic polymeric drug for brain cancer, 2020, Journal of Controlled Release
  • EGFRvIII expression and isocitrate dehydrogenase mutations in patients with glioma, 2020, Oncology Letters
  • Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks, 2020, UNC Libraries

Frequent co-authors collaborating with Valerie include:

  • Amrita Sule
  • Lawrence F. Povirk
  • Raid Jastania
  • Hisham Alkhalidi
  • Khalid AlQuthami

Valerie's research has been published in a number of venues, with frequent contributions to:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Medical Case Reports Journal
  • Cellular and Molecular Life Sciences
  • Journal of Controlled Release

Best Publications

  • Regulation and mechanisms of mammalian double-strand break repair

    Kristoffer Valerie;Lawrence F Povirk

  • Stress and radiation-induced activation of multiple intracellular signaling pathways.

    Paul Dent;Adly Yacoub;Joseph Contessa;Ruben Caron

  • Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation.

    R K Schmidt-Ullrich;R B Mikkelsen;P Dent;D G Todd

  • Radiation-induced Release of Transforming Growth Factor α Activates the Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase Pathway in Carcinoma Cells, Leading to Increased Proliferation and Protection from Radiation-induced Cell Death

    Paul Dent;Dean B. Reardon;Jong Sung Park;Geoffrey Bowers

  • mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK

    Devanand Sarkar;Zao-Zhong Su;Irina V. Lebedeva;Moira Sauane

  • Signal transduction and cellular radiation responses

    Rupert K. Schmidt-Ullrich;Paul Dent;Steven Grant;Ross B. Mikkelsen

  • Radiation-induced cell signaling: inside-out and outside-in

    Kristoffer Valerie;Adly Yacoub;Michael P. Hagan;David T. Curiel

  • Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

    Sarah E. Golding;Elizabeth Rosenberg;Nicholas Valerie;Isa Hussaini

  • Activation of the Nuclear Factor κB Pathway by Astrocyte Elevated Gene-1: Implications for Tumor Progression and Metastasis

    Luni Emdad;Devanand Sarkar;Zao-zhong Su;Aaron Randolph

  • Deoxycholic Acid (DCA) Causes Ligand-independent Activation of Epidermal Growth Factor Receptor (EGFR) and FAS Receptor in Primary Hepatocytes: Inhibition of EGFR/Mitogen-activated Protein Kinase-Signaling Module Enhances DCA-induced Apoptosis

    Liang Qiao;Elaine Studer;Kevin Leach;Robert McKinstry

  • Activation of human immunodeficiency virus type 1 by DNA damage in human cells.

    Kristoffer Valerie;Anne Delers;Claudine Bruck;Clotilde Thiriart

  • BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

    Sagar Sengupta;Steven P. Linke;Remy Pedeux;Qin Yang

  • Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene

    Dong-chul Kang;Rahul V Gopalkrishnan;Lin Lin;Aaron Randolph

  • The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

    Stephen T. Durant;Li Zheng;Yingchun Wang;Kan Chen

  • Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.

    Zao-Zhong Su;Irina V Lebedeva;Devanand Sarkar;Rahul V Gopalkrishnan

  • Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells.

    Sarah E. Golding;Rhiannon N. Morgan;Bret R. Adams;Amy J. Hawkins

  • Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

    Liang Qiao;Song Iy Han;Youwen Fang;Jong Sung Park

  • Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.

    Sarah E. Golding;Elizabeth Rosenberg;Steven Neill;Paul Dent

  • The relative role of ErbB1–4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells

    G Bowers;G Bowers;D Reardon;D Reardon;T Hewitt;P Dent

  • Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

    Tong Zhou;Jae Wan Lee;Haritha Tatavarthi;James R. Lupski

Frequent Co-Authors

Paul Dent
Paul Dent Virginia Commonwealth University
Paul B. Fisher
Paul B. Fisher Virginia Commonwealth University
Devanand Sarkar
Devanand Sarkar Virginia Commonwealth University
Paul B. Fisher
Paul B. Fisher Virginia Commonwealth University
Zao-Zhong Su
Zao-Zhong Su Columbia University Medical Center
Steven Grant
Steven Grant Virginia Commonwealth University
David A. Gewirtz
David A. Gewirtz Virginia Commonwealth University
Adly Yacoub
Adly Yacoub Virginia Commonwealth University
Pankaj Gupta
Pankaj Gupta Post Graduate Institute of Medical Education and Research
Steven J. Neill
Steven J. Neill University of the West of England

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