Winfried Barchet mainly investigates Interferon, Cell biology, Virology, Molecular biology and RNA. His work in the fields of Interferon, such as Alpha interferon, intersects with other areas such as Toll-Like Receptor 9 and TLR9. His Cell biology research is multidisciplinary, incorporating elements of NK-92, Interleukin 21 and Granzyme B, Granzyme A.
His work in Virology is not limited to one particular discipline; it also encompasses Innate immune system. Winfried Barchet combines subjects such as Virus and Herpes simplex virus with his study of Innate immune system. His studies in Molecular biology integrate themes in fields like Non-coding RNA, 2'-O-methylation, Gene expression, Five-prime cap and RNA-binding protein.
His primary areas of study are Immunology, Cell biology, Innate immune system, Interferon and Immune system. The study incorporates disciplines such as Cytokine, Antigen-presenting cell, Interleukin 21, Dendritic cell and Endothelium in addition to Cell biology. His research in Innate immune system focuses on subjects like RNA, which are connected to Molecular biology.
Interferon is the subject of his research, which falls under Virology. His Virology research integrates issues from RIG-I and Microbiology. His work deals with themes such as Respiratory burst, Receptor, Nucleic acid and DNA, which intersect with Immune system.
His scientific interests lie mostly in Cell biology, Innate immune system, Interferon, Immune system and Molecular biology. His research in Cell biology intersects with topics in Cytokine, TLR7, Dendritic cell, Chemokine and Endogeny. His Innate immune system study combines topics from a wide range of disciplines, such as RNA and Immunity.
His Interferon study contributes to a more complete understanding of Virology. His study in Virology is interdisciplinary in nature, drawing from both RIG-I and Nucleotide. His Immune system study is associated with Immunology.
Winfried Barchet spends much of his time researching Immunology, Interferon, Nucleic acid, Immune system and Cytotoxic T cell. He works in the field of Interferon, focusing on Alpha interferon in particular. Within one scientific family, Winfried Barchet focuses on topics pertaining to Pattern recognition receptor under Nucleic acid, and may sometimes address concerns connected to Cancer.
His work carried out in the field of Immune system brings together such families of science as Receptor and Drug discovery. His Cytotoxic T cell research includes themes of Cancer cell, CD8, Immunogenicity, Immunotherapy and Effector. Cellular immunity and Cell biology are frequently intertwined in his study.
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Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
William J. Grossman;James W. Verbsky;Winfried Barchet;Marco Colonna.
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
Leonid Gitlin;Winfried Barchet;Susan Gilfillan;Marina Cella.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
Thirumala Devi Kanneganti;Nesrin Özören;Mathilde Body-Malapel;Amal Amer.
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.
Anne Krug;Anthony R French;Winfried Barchet;Jens A.A Fischer.
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.
Anne Krug;Gary D. Luker;Gary D. Luker;Winfried Barchet;Winfried Barchet;David A. Leib;David A. Leib.
Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus
Martin Schlee;Andreas Roth;Veit Hornung;Christina Amparo Hagmann.
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
Pu Gao;Manuel Ascano;Yang Wu;Winfried Barchet.
Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
Roland Züst;Roland Züst;Luisa Cervantes-Barragan;Matthias Habjan;Reinhard Maier.
Nature Immunology (2011)
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1|[beta]| production
Hendrik Poeck;Michael Bscheider;Olaf Gross;Olaf Gross;Katrin Finger.
Nature Immunology (2010)
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
Delphine Goubau;Martin Schlee;Safia Deddouche;Andrea J. Pruijssers.
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