What is he best known for?
The fields of study he is best known for:
- Enzyme
- Biochemistry
- Amino acid
His primary areas of study are Biochemistry, Heparan sulfate, Proteoglycan, Sulfation and Binding site.
Malcolm Lyon is involved in the study of Biochemistry that focuses on Glycosaminoglycan in particular.
His Heparan sulfate research is multidisciplinary, incorporating elements of Fibronectin, Plasma protein binding, Stereochemistry and Affinity chromatography.
Malcolm Lyon interconnects Immunology, Cell adhesion, Endothelial Cell-Specific Molecule 1 and Hepatocyte growth factor in the investigation of issues within Proteoglycan.
His Sulfation research incorporates themes from Extracellular matrix, Disaccharide and Heparin.
His studies in Binding site integrate themes in fields like Amino acid, Complement control protein, Complement system, Glycoprotein and Affinities.
His most cited work include:
- Structure and function of heparan sulphate proteoglycans (415 citations)
- Interaction of hepatocyte growth factor with heparan sulfate : elucidation of the major heparan sulfate structural determinants (285 citations)
- The Interaction of the Transforming Growth Factor-βs with Heparin/Heparan Sulfate Is Isoform-specific (226 citations)
What are the main themes of his work throughout his whole career to date?
Malcolm Lyon spends much of his time researching Biochemistry, Heparan sulfate, Sulfation, Hepatocyte growth factor and Binding site.
His work on Biochemistry deals in particular with Proteoglycan, Dermatan sulfate, Glycosaminoglycan, Heparan sulphate and Enzyme.
His work in Heparan sulfate tackles topics such as Fibroblast growth factor which are related to areas like Extracellular and Extracellular matrix.
His Sulfation study incorporates themes from Size-exclusion chromatography, Disaccharide, Tetrasaccharide and Heparinase.
The Hepatocyte growth factor study combines topics in areas such as Molecular biology, Growth factor and Cell biology.
His Binding site study which covers Plasma protein binding that intersects with Dissociation constant, Perlecan and Affinity chromatography.
He most often published in these fields:
- Biochemistry (63.64%)
- Heparan sulfate (37.66%)
- Sulfation (29.87%)
What were the highlights of his more recent work (between 2007-2011)?
- Biochemistry (63.64%)
- Heparan sulfate (37.66%)
- Stereochemistry (12.99%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Biochemistry, Heparan sulfate, Stereochemistry, Dermatan sulfate and Glycosaminoglycan.
In the subject of general Biochemistry, his work in Binding site is often linked to Selectivity, thereby combining diverse domains of study.
Malcolm Lyon combines subjects such as Liver cancer and Hepatocellular carcinoma with his study of Heparan sulfate.
The various areas that Malcolm Lyon examines in his Stereochemistry study include Tetrasaccharide, Chemical modification and Factor H.
His Dermatan sulfate study combines topics from a wide range of disciplines, such as Sulfation, Chondroitin and Hepatocyte growth factor.
In his research on the topic of Chondroitin sulfate, Growth factor is strongly related with Proteoglycan.
Between 2007 and 2011, his most popular works were:
- Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration (195 citations)
- A New Map of Glycosaminoglycan and C3b Binding Sites on Factor H (180 citations)
- A simplified and sensitive fluorescent method for disaccharide analysis of both heparan sulfate and chondroitin/dermatan sulfates from biological samples (77 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Biochemistry
- Amino acid
His main research concerns Glycosaminoglycan, ADAMTS, Aggrecan, Aggrecanase and Pathology.
His study of Heparan sulfate is a part of Glycosaminoglycan.
Among his ADAMTS studies, you can observe a synthesis of other disciplines of science such as Matrix metalloproteinase, Extracellular matrix and Intervertebral disc.
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