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Shuhei Yamada

Shuhei Yamada

D-Index & Metrics

Chemistry

D-Index
46
Citations
7187
World Ranking
16107
National Ranking
1270

Overview

Shuhei Yamada is affiliated with Meijo University in Japan, with a primary research focus in the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Cell Biology, Molecular Biology, Genetics, Organic Chemistry, and Cancer Research.

The scientist has contributed significantly to topics related to Proteoglycans and Glycosaminoglycans research, Connective tissue disorders research, Glycosylation and Glycoproteins Research, Carbohydrate Chemistry and Synthesis, Fibroblast Growth Factor Research, Skin and Cellular Biology Research, and Protease and Inhibitor Mechanisms.

Yamada's recent publications include the following papers:

  • Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis, 2021, Frontiers in Genetics
  • An Overview of in vivo Functions of Chondroitin Sulfate and Dermatan Sulfate Revealed by Their Deficient Mice, 2021, Frontiers in Cell and Developmental Biology
  • The Specific Role of Dermatan Sulfate as an Instructive Glycosaminoglycan in Tissue Development, 2022, International Journal of Molecular Sciences
  • Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia, 2021, Cancer Science
  • Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain, 2020, Biochimica et Biophysica Acta (BBA) - General Subjects

Frequent co-authors of Yamada include:

  • Shuji Mizumoto
  • Tomoki Kosho
  • Yuko Nitahara-Kasahara
  • Takashi Okada
  • Shinji Miyata

In terms of publication venues, Yamada regularly publishes in:

  • Frontiers in Cell and Developmental Biology
  • Trends in Glycoscience and Glycotechnology
  • International Journal of Molecular Sciences
  • Genes
  • Journal of Human Genetics

The breadth of Yamada's research spans molecular mechanisms underlying glycosaminoglycan biosynthesis, functional roles of chondroitin sulfate and dermatan sulfate in tissue development, and metabolic regulation under stress conditions. Their interdisciplinary contributions also cover connective tissue disorders and the chemistry of carbohydrates.

Best Publications

  • Potential therapeutic application of chondroitin sulfate/dermatan sulfate.

    Shuhei Yamada;Kazuyuki Sugahara

  • Oversulfated Chondroitin/Dermatan Sulfates Containing GlcAβ1/IdoAα1–3GalNAc(4,6-O-disulfate) Interact with L- and P-selectin and Chemokines

    Hiroto Kawashima;Kazuyuki Atarashi;Mayumi Hirose;Jun Hirose

  • Evolution of glycosaminoglycans: Comparative biochemical study.

    Shuhei Yamada;Kazuyuki Sugahara;Suat Özbek

  • Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.

    Anurag Purushothaman;Toru Uyama;Fumi Kobayashi;Shuhei Yamada

  • Chondroitin Sulfate Chains on Syndecan-1 and Syndecan-4 from Normal Murine Mammary Gland Epithelial Cells Are Structurally and Functionally Distinct and Cooperate with Heparan Sulfate Chains to Bind Growth Factors A NOVEL FUNCTION TO CONTROL BINDING OF MIDKINE, PLEIOTROPHIN, AND BASIC FIBROBLAST GROWTH FACTOR

    Sarama Sathyaseelan Deepa;Shuhei Yamada;Masahiro Zako;Olga Goldberger

  • Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

    Alexandra Abramsson;Sindhulakshmi Kurup;Marta Busse;Shuhei Yamada

  • Molecular interactions between chondroitin–dermatan sulfate and growth factors/receptors/matrix proteins

    Shuji Mizumoto;Shuhei Yamada;Kazuyuki Sugahara;Kazuyuki Sugahara

  • Structural Recognition by Recombinant Human Heparanase That Plays Critical Roles in Tumor Metastasis: HIERARCHICAL SULFATE GROUPS WITH DIFFERENTIAL EFFECTS AND THE ESSENTIAL TARGET DISULFATED TRISACCHARIDE SEQUENCE *

    Yukihiko Okada;Shuhei Yamada;Minako Toyoshima;Jian Dong

  • Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome.

    Noriko Miyake;Tomoki Kosho;Shuji Mizumoto;Tatsuya Furuichi

  • Chondroitin sulfate/dermatan sulfate hybrid chains from embryonic pig brain, which contain a higher proportion of L-iduronic acid than those from adult pig brain, exhibit neuritogenic and growth factor binding activities.

    Xingfeng Bao;Shuji Nishimura;Tadahisa Mikami;Shuhei Yamada

  • Chondroitin Sulfate Characterized by the E-disaccharide Unit Is a Potent Inhibitor of Herpes Simplex Virus Infectivity and Provides the Virus Binding Sites on gro2C Cells

    Kicki Bergefall;Edward Trybala;Maria Johansson;Toru Uyama

  • Demonstration of glycosaminoglycans in Caenorhabditis elegans

    Shuhei Yamada;Irma Van Die;Dirk H. Van den Eijnden;Akiko Yokota

  • Structural studies on the bacterial lyase-resistant tetrasaccharides derived from the antithrombin III-binding site of porcine intestinal heparin.

    S. Yamada;K. Yoshida;M. Sugiura;K. Sugahara

  • Structure and Function of Oversulfated Chondroitin Sulfate Variants Unique Sulfation Patterns and Neuroregulatory Activities

    Kazuyuki Sugahara;Shuhei Yamada

  • Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence.

    Tomoyuki Kaneiwa;Shuji Mizumoto;Kazuyuki Sugahara;Shuhei Yamada

  • One- and two-dimensional 1H-NMR characterization of two series of sulfated disaccharides prepared from chondroitin sulfate and heparan sulfate/heparin by bacterial eliminase digestion.

    Shuhei Yamada;Keiichi Yoshida;Makiko Sugiura;Kazuyuki Sugahara

  • Involvement of highly sulfated chondroitin sulfate in the metastasis of the Lewis lung carcinoma cells.

    Fuchuan Li;Fuchuan Li;Gerdy B. ten Dam;Sengottuvelan Murugan;Shuhei Yamada;Shuhei Yamada

  • Novel Tetrasaccharides Isolated from Squid Cartilage Chondroitin Sulfate E Contain Unusual Sulfated Disaccharide Units GlcA(3-O-sulfate)β1–3GalNAc(6-O-sulfate) or GlcA(3-O-sulfate)β1–3GalNAc(4,6-O-disulfate)

    Akiko Kinoshita;Shuhei Yamada;Stuart M. Haslam;Howard R. Morris

  • Heparin-binding Growth Factor, Pleiotrophin, Mediates Neuritogenic Activity of Embryonic Pig Brain-derived Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains

    Xingfeng Bao;Tadahisa Mikami;Shuhei Yamada;Andreas Faissner

  • Important role of heparan sulfate in postnatal islet growth and insulin secretion.

    Iwao Takahashi;Naoya Noguchi;Koji Nata;Shuhei Yamada

  • Novel sulfated oligosaccharides containing 3-O-sulfated glucuronic acid from king crab cartilage chondroitin sulfate K. Unexpected degradation by chondroitinase ABC.

    Kazuyuki Sugahara;Yukako Tanaka;Shuhei Yamada;Nobuko Seno

Frequent Co-Authors

Kazuyuki Sugahara
Kazuyuki Sugahara Hokkaido University
Howard R. Morris
Howard R. Morris Imperial College London
Noriko Miyake
Noriko Miyake Yokohama City University
Hiroshi Kitagawa
Hiroshi Kitagawa Kobe Pharmaceutical University
Kay-Hooi Khoo
Kay-Hooi Khoo National Taiwan University
Stuart M. Haslam
Stuart M. Haslam Imperial College London
Naomichi Matsumoto
Naomichi Matsumoto Yokohama City University
Anne Dell
Anne Dell Imperial College London
Toin H. van Kuppevelt
Toin H. van Kuppevelt Radboud University

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