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Biology and Biochemistry

D-Index
74
Citations
19141
World Ranking
5614
National Ranking
23

Overview

Kay-Hooi Khoo is affiliated with National Taiwan University in Taiwan and has contributed extensively to research in biochemistry, genetics, and molecular biology. Their work spans multiple specialized subfields including molecular biology, immunology, infectious diseases, spectroscopy, and organic chemistry.

The scientist's research focuses substantially on glycosylation and glycoproteins, with additional significant contributions to galectins and cancer biology, carbohydrate chemistry and synthesis, viral gastroenteritis research and epidemiology, genomics and phylogenetic studies, advanced proteomics techniques and applications, as well as SARS-CoV-2 and COVID-19 research.

Frequent collaborators in their research include Tzu-Jing Yang, Shang-Te Danny Hsu, Chu-Wei Kuo, Yu-Xi Tsai, and Ning-En Chang. These collaborations reflect a network of co-authors with whom they have published multiple papers, indicating ongoing partnerships in their scientific endeavors.

The scientist's publications have appeared regularly in several venues, with the most frequent including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Communications
  • Nature Methods
  • Proceedings of the National Academy of Sciences

Among their recent papers are:

  • Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity, 2020, Cancer Research
  • Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis, 2021, Nature Methods
  • Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans, 2020, Proceedings of the National Academy of Sciences
  • Carbohydrate Sulfation As a Mechanism for Fine-Tuning Siglec Ligands, 2021, ACS Chemical Biology
  • Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer, 2020, Cancer Immunology Research

Kay-Hooi Khoo's research encompasses both fundamental and applied aspects of molecular biology and immunology, focusing on mechanisms related to glycoproteins and their role in disease processes including cancer and viral infections. Their work utilizes methods from spectroscopy and proteomics to structural analyses such as cryo-electron microscopy.

Best Publications

  • Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

    Chia Wei Li;Seung Oe Lim;Weiya Xia;Heng Huan Lee

  • Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.

    Jong-Ho Cha;Wen-Hao Yang;Weiya Xia;Yongkun Wei

  • Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.

    Chia Wei Li;Seung Oe Lim;Ezra M. Chung;Yong Soo Kim

  • Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study.

    Yoshinao Wada;Parastoo Azadi;Catherine E. Costello;Anne Dell

  • Mycobacterial lipoarabinomannan: an extraordinary lipoheteroglycan with profound physiological effects.

    Delphi Chatterjee;Kay-Hooi Khoo

  • Glycans on influenza hemagglutinin affect receptor binding and immune response.

    Cheng-Chi Wang;Juine-Ruey Chen;Yung-Chieh Tseng;Che-Hsiung Hsu

  • Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida.

    Poh-Choo Pang;Philip C. N. Chiu;Cheuk-Lun Lee;Lan-Yi Chang

  • Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

    Ying-Chih Liu;Hsin-Yung Yen;Chien-Yu Chen;Chein-Hung Chen

  • STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.

    Jung Mao Hsu;Weiya Xia;Yi Hsin Hsu;Li Chuan Chan;Li Chuan Chan

  • Studies on the immuno-Modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-Containing glycoprotein fraction responsible for the activities

    Yuan-Yuan Wang;Kay-Hooi Khoo;Shui-Tein Chen;Chun-Cheng Lin

  • A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resonance spectroscopy

    Gurdyal S. Besra;Kay-Hooi Khoo;Michael R. McNeil;Anne Dell

  • Mass Spectrometry of Carbohydrate-Containing Biopolymers

    Anne Dell;Andrew J. Reason;Kay-Hooi Khoo;Maria Panico

  • The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s).

    L. Stephens;T. Radenberg;U. Thiel;G. Vogel

  • Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides.

    Hung-Sen Chen;Yow-Fu Tsai;Steven Lin;Chia-Ching Lin

  • The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan.

    Vincent E. Escuyer;Marie-Annick Lety;Jordi B. Torrelles;Kay-Hooi Khoo

  • Definition of the full extent of glycosylation of the 45-kilodalton glycoprotein of Mycobacterium tuberculosis.

    Karen M. Dobos;Kay-Hooi Khoo;Kristine M. Swiderek;Patrick J. Brennan

  • Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium

    Kay-Hooi Khoo;Anne Dell;Howard R. Morris;Patrick J. Brennan

  • Cysteine S-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation *

    Yi-Yun Chen;Hsing-Mao Chu;Hsing-Mao Chu;Kuan-Ting Pan;Chun-Hung Teng

  • Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment.

    Junya Mitoma;Xingfeng Bao;Bronislawa Petryanik;Patrick Schaerli

  • Structural mapping of the glycans from the egg glycoproteins of Schistosoma mansoni and Schistosoma japonicum: identification of novel core structures and terminal sequences

    Kay-Hooi Khoo;Delphi Chatterjee;John P. Caulfield;Howard R. Morris

Frequent Co-Authors

Anne Dell
Anne Dell Imperial College London
Howard R. Morris
Howard R. Morris Imperial College London
Delphi Chatterjee
Delphi Chatterjee Colorado State University
Patrick J. Brennan
Patrick J. Brennan Colorado State University
Michael R. McNeil
Michael R. McNeil Colorado State University
Gurdyal S. Besra
Gurdyal S. Besra University of Birmingham
Koichi Kato
Koichi Kato National Institutes of Natural Sciences
Ken Kitajima
Ken Kitajima Nagoya University
Chi-Huey Wong
Chi-Huey Wong Scripps Research Institute
Stuart M. Haslam
Stuart M. Haslam Imperial College London

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