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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
16613
World Ranking
12975
National Ranking
5533

Overview

Linda Van Aelst is affiliated with Cold Spring Harbor Laboratory in the United States. Their research spans several interconnected fields, including Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Within these broad disciplines, their work focuses on Molecular Biology, Immunology, Cell Biology, Genetics, and Oncology.

The scientist's research covers a range of topics, highlighting cellular and molecular processes as well as disease mechanisms. Key topics of their work include:

  • Cellular transport and secretion
  • Immune cells in cancer
  • Cancer, Stress, Anesthesia, and Immune Response
  • Neurogenesis and neuroplasticity mechanisms
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Genetics and Neurodevelopmental Disorders

Linda Van Aelst has contributed to several notable publications. Recent papers include:

  • Connecting copper and cancer: from transition metal signalling to metalloplasia (2021) in Nature Reviews. Cancer
  • Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment (2024) in Cancer Cell
  • Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders (2020) in Trends in Neurosciences
  • Cancer cell CCR2 orchestrates suppression of the adaptive immune response (2020) in The Journal of Experimental Medicine
  • Microglia regulate chandelier cell axo-axonic synaptogenesis (2022) in Proceedings of the National Academy of Sciences

Their frequent co-authors include Shanu George, Evdokia Michalopoulou, Mikala Egeblad, Nicholas B. Gallo, and Nicholas K. Tonks. These collaborations reflect a multidisciplinary approach to research, combining expertise in cancer biology, neuroscience, and immunology.

Linda Van Aelst often publishes in venues associated with Cold Spring Harbor Laboratory, such as bioRxiv, as well as more specialized journals like Genes & Development and Proceedings of the National Academy of Sciences. The list of frequent publication venues is:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genes & Development
  • Proceedings of the National Academy of Sciences
  • Nature Reviews. Cancer
  • Cancer Cell

Best Publications

  • Connecting copper and cancer: from transition metal signalling to metalloplasia.

    Eva J Ge;Ashley I Bush;Angela Casini;Paul A Cobine

  • The role of the Rho GTPases in neuronal development

    Eve Ellen Govek;Sarah E. Newey;Linda Van Aelst

  • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

    Athena W. Lin;Marta Barradas;James C. Stone;Linda van Aelst

  • Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

    J.Julius Zhu;J.Julius Zhu;Yi Qin;Yi Qin;Mingming Zhao;Linda Van Aelst

  • Multiple Ras functions can contribute to mammalian cell transformation.

    Michael A. White;Charles Nicolette;Audrey Minden;Anthony Polverino

  • CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.

    Tina L. Gumienny;Tina L. Gumienny;Enrico Brugnera;Annie-Carole Tosello-Trampont;Jason M. Kinchen;Jason M. Kinchen

  • The paraventricular thalamus controls a central amygdala fear circuit.

    Mario A. Penzo;Vincent Robert;Jason Tucciarone;Dimitri De Bundel

  • Rho GTPases, dendritic structure, and mental retardation.

    Sarah E. Newey;Vanisree Velamoor;Eve-Ellen Govek;Linda Van Aelst

  • A Novel Regulator of p21-activated Kinases

    Shubha Bagrodia;Stephen J. Taylor;K. Antonia Jordon;Linda Van Aelst

  • The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis.

    Eve-Ellen Govek;Eve-Ellen Govek;Sarah E Newey;Colin J Akerman;Justin R Cross

  • RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase.

    Tom Joneson;Michele McDonough;Dafna Bar-Sagi;Linda Van Aelst

  • Role of Rho family GTPases in epithelial morphogenesis

    Linda Van Aelst;Marc Symons

  • The role of Rho GTPases in disease development.

    Benjamin Boettner;Linda Van Aelst

  • A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.

    Crislyn D'Souza‐Schorey;Rita L. Boshans;Michelle McDonough;Philip D. Stahl

  • Control of cell adhesion dynamics by Rap1 signaling

    Benjamin Boettner;Linda Van Aelst

  • Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging

    Ryohei Yasuda;Ryohei Yasuda;Christopher D Harvey;Christopher D Harvey;Haining Zhong;Aleksander Sobczyk;Aleksander Sobczyk

  • Rho GTPases and activity-dependent dendrite development

    Linda Van Aelst;Hollis T Cline

  • Rap2-JNK Removes Synaptic AMPA Receptors during Depotentiation

    Yinghua Zhu;Daniel Pak;Yi Qin;Yi Qin;Stefanie G. McCormack

  • The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

    Benjamin Boettner;Eve-Ellen Govek;Justin Cross;Linda Van Aelst

  • ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA.

    Rita L. Boshans;Stacey Szanto;Linda van Aelst;Crislyn D'Souza-Schorey

Frequent Co-Authors

Pier Paolo Pandolfi
Pier Paolo Pandolfi Beth Israel Deaconess Medical Center
Akiko Hata
Akiko Hata University of California, San Francisco
Ryohei Yasuda
Ryohei Yasuda Max Planck Society
Douglas T. Fearon
Douglas T. Fearon Cold Spring Harbor Laboratory
Ashish Lal
Ashish Lal National Institutes of Health
Crislyn D'Souza-Schorey
Crislyn D'Souza-Schorey University of Notre Dame
David A. Tuveson
David A. Tuveson Cold Spring Harbor Laboratory
Karel Svoboda
Karel Svoboda Allen Institute
Judy Lieberman
Judy Lieberman Boston Children's Hospital

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