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Molecular Biology

D-Index
53
Citations
13983
World Ranking
2368
National Ranking
1171

Overview

Ashish Lal is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant emphasis on molecular biology and cancer research. Their work also touches upon surgery, oncology, and epidemiology.

The scientist's main topics of study revolve around RNA research and splicing, cancer-related molecular mechanisms, and RNA modifications in cancer. Additional interests include RNA and protein synthesis mechanisms, circular RNAs in diseases, pharmacological receptor mechanisms and effects, and microRNA in disease regulation.

Frequent collaborators in Ashish Lal's research include Ioannis Grammatikakis, Xiao Ling Li, Bruna Rodrigues Muys, Lőrinc Sándor Pongor, and Mirit I. Aladjem. These co-authors have contributed to numerous joint publications.

Their publications appear most frequently in the journal Molecular and Cellular Biology, along with multiple appearances in bioRxiv (Cold Spring Harbor Laboratory). Other venues include eLife, Mammalian Genome, and Nucleic Acids Research.

Recent papers by Ashish Lal showcase various aspects of RNA biology and cancer:

  • When Long Noncoding Becomes Protein Coding, 2020, Molecular and Cellular Biology
  • A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells, 2020, eLife
  • Significance of lncRNA abundance to function, 2021, Mammalian Genome
  • AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production, 2020, Nucleic Acids Research
  • The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma, 2020, Genes & Development

Best Publications

  • Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

    Madhusudhanan Sukumar;Jie Liu;Yun Ji;Murugan Subramanian

  • Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB.

    Vidisha Tripathi;Zhen Shen;Arindam Chakraborty;Sumanprava Giri

  • miR-24 Inhibits Cell Proliferation by Targeting E2F2, MYC, and Other Cell-Cycle Genes via Binding to “Seedless” 3′UTR MicroRNA Recognition Elements

    Ashish Lal;Francisco Navarro;Christopher A. Maher;Laura E. Maliszewski

  • Phosphorylation of HuR by Chk2 regulates SIRT1 expression

    Kotb Abdelmohsen;Rudolf Pullmann;Ashish Lal;Hyeon Ho Kim

  • Identification of a target RNA motif for RNA-binding protein HuR

    Isabel López de Silanes;Ming Zhan;Ashish Lal;Xiaoling Yang

  • Desperately seeking microRNA targets.

    Marshall Thomas;Judy Lieberman;Ashish Lal;Ashish Lal

  • Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

    Ashish Lal;Krystyna Mazan-Mamczarz;Tomoko Kawai;Xiaoling Yang

  • MicroRNAs and their target gene networks in breast cancer.

    Elizabeth O'Day;Ashish Lal

  • miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases

    Derek M. Dykxhoorn;Yichao Wu;Huangming Xie;Fengyan Yu;Fengyan Yu

  • RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α

    Stefanie Galbán;Yuki Kuwano;Rudolf Pullmann;Jennifer L. Martindale

  • p16INK4a Translation Suppressed by miR-24

    Ashish Lal;Ashish Lal;Hyeon-Ho Kim;Kotb Abdelmohsen;Yuki Kuwano

  • miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.

    Ashish Lal;Yunfeng Pan;Francisco Navarro;Derek M Dykxhoorn

  • Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling

    Ashish Lal;Marshall P. Thomas;Marshall P. Thomas;Gabriel Altschuler;Francisco Navarro;Francisco Navarro

  • Posttranscriptional orchestration of an anti-apoptotic program by HuR.

    Kotb Abdelmohsen;Ashish Lal;Hyeon Ho Kim;Myriam Gorospe

  • HuR: post-transcriptional paths to malignancy.

    Isabel López de Silanes;Ashish Lal;Myriam Gorospe

  • Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes

    Emmette R. Hutchison;Emmette R. Hutchison;Elisa M. Kawamoto;Dennis D. Taub;Ashish Lal

  • RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

    Marcel P. Van Der Brug;Jeff Blackinton;Jeff Blackinton;Jayanth Chandran;Ling Yang Hao

  • Molecular basis for antagonism between PDGF and the TGFβ family of signalling pathways by control of miR-24 expression

    Mun Chun Chan;Aaron C Hilyard;Connie Wu;Brandi N Davis

  • Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs.

    Rudolf Pullmann;Hyeon Ho Kim;Kotb Abdelmohsen;Ashish Lal

  • Nuclear HuR accumulation through phosphorylation by Cdk1

    Hyeon Ho Kim;Kotb Abdelmohsen;Ashish Lal;Rudolf Pullmann

Frequent Co-Authors

Myriam Gorospe
Myriam Gorospe National Institutes of Health
Judy Lieberman
Judy Lieberman Boston Children's Hospital
Kannanganattu V. Prasanth
Kannanganattu V. Prasanth University of Illinois at Urbana-Champaign
Kotb Abdelmohsen
Kotb Abdelmohsen National Institutes of Health
Xiaoling Yang
Xiaoling Yang National Institutes of Health
Jennifer L. Martindale
Jennifer L. Martindale National Institutes of Health
Paul S. Meltzer
Paul S. Meltzer National Institutes of Health
Sven Diederichs
Sven Diederichs German Cancer Research Center
Akiko Hata
Akiko Hata University of California, San Francisco
Bing Lim
Bing Lim Thymmune Therapeutics

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