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Biology and Biochemistry

D-Index
56
Citations
24855
World Ranking
14142
National Ranking
995

Overview

Sven Diederichs is affiliated with the German Cancer Research Center in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine as well. The scientist's work emphasizes Molecular Biology, Cancer Research, and Oncology, while also addressing topics related to Pulmonary and Respiratory Medicine and Cell Biology.

The main topics of Sven Diederichs' research include RNA modifications and cancer, RNA research and splicing, RNA and protein synthesis mechanisms, cancer-related molecular mechanisms research, epigenetics and DNA methylation, CRISPR and genetic engineering, and CAR-T cell therapy research.

They have published numerous papers, with some notable recent examples including:

  • The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer (2020, Nature Communications)
  • RBP2GO: a comprehensive pan-species database on RNA-binding proteins, their interactions and functions (2020, Nucleic Acids Research)
  • The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway (2020, eLife)
  • Saturation genome editing maps the functional spectrum of pathogenic VHL alleles (2024, Nature Genetics)
  • The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells (2020, Cancers)

Their frequent co-authors include:

  • Maïwen Caudron-Herger
  • Jeanette Seiler
  • Bernward Passlick
  • Marisa Riester
  • Elsa Wassmer

Regarding publication venues, Sven Diederichs has contributed multiple works to:

  • Nature Communications
  • Cancers
  • Cancer Letters
  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Many roads to maturity: microRNA biogenesis pathways and their regulation

    Julia Winter;Stephanie Jung;Sarina Keller;Richard I. Gregory

  • MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer.

    Ping Ji;Sven Diederichs;Wenbing Wang;Sebastian Böing

  • Detection of Mutations in EGFR in Circulating Lung-Cancer Cells

    Shyamala Maheswaran;Lecia V. Sequist;Sunitha Nagrath;Lindsey Ulkus

  • The hallmarks of cancer: a long non-coding RNA point of view.

    Tony Gutschner;Sven Diederichs

  • The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells

    Tony Gutschner;Monika Hämmerle;Moritz Eißmann;Jeff Hsu

  • Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression

    Sven Diederichs;Daniel A. Haber

  • MALAT1 -- a paradigm for long noncoding RNA function in cancer

    Tony Gutschner;Monika Hämmerle;Sven Diederichs;Sven Diederichs

  • Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients

    Luca Quagliata;Matthias S. Matter;Salvatore Piscuoglio;Salvatore Piscuoglio;Leila Arabi

  • Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development.

    Moritz Eißmann;Tony Gutschner;Monika Hämmerle;Stefan Günther

  • Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.

    Marcel Klingenberg;Marcel Klingenberg;Marcel Klingenberg;Akiko Matsuda;Sven Diederichs;Tushar Patel

  • Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells

    Carsten Müller-Tidow;Björn Steffen;Thomas Cauvet;Lara Tickenbrock

  • The four dimensions of noncoding RNA conservation.

    Sven Diederichs

  • Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells

    Pedro de Souza Rocha Simonini;Pedro de Souza Rocha Simonini;Achim Breiling;Nibedita Gupta;Mahdi Malekpour

  • Tumor-derived exosomes modulate PD-L1 expression in monocytes.

    Franziska Haderk;Ralph Schulz;Murat Iskar;Laura Llaó Cid

  • From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis

    Sonam Dhamija;Sonam Dhamija;Sonam Dhamija;Sven Diederichs;Sven Diederichs;Sven Diederichs

  • Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization

    Julia Winter;Sven Diederichs

  • Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1).

    Monika Hämmerle;Tony Gutschner;Hannah Uckelmann;Sevim Ozgur

  • The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations.

    Sven Diederichs;Sven Diederichs;Lorenz Bartsch;Julia C Berkmann;Karin Fröse

  • Sequence Variations of MicroRNAs in Human Cancer: Alterations in Predicted Secondary Structure Do Not Affect Processing

    Sven Diederichs;Daniel A. Haber

  • S100 Family Members and Trypsinogens Are Predictors of Distant Metastasis and Survival in Early-Stage Non-Small Cell Lung Cancer

    Sven Diederichs;Etmar Bulk;Björn Steffen;Ping Ji

Frequent Co-Authors

Wolfgang E. Berdel
Wolfgang E. Berdel University of Münster
Carsten Müller-Tidow
Carsten Müller-Tidow University Hospital Heidelberg
Daniel A. Haber
Daniel A. Haber Harvard University
Peter Schirmacher
Peter Schirmacher University Hospital Heidelberg
Hubert Serve
Hubert Serve Goethe University Frankfurt
Gabriele Köhler
Gabriele Köhler University of Münster
H. Phillip Koeffler
H. Phillip Koeffler Cedars-Sinai Medical Center
Kannanganattu V. Prasanth
Kannanganattu V. Prasanth University of Illinois at Urbana-Champaign
Ashish Lal
Ashish Lal National Institutes of Health
Michael Boutros
Michael Boutros German Cancer Research Center

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