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Biology and Biochemistry

D-Index
72
Citations
24928
World Ranking
6168
National Ranking
470

Overview

Hitoshi Nakagama is affiliated with the National Cancer Research Institute, UK, based in the United Kingdom. Their research primarily spans biochemistry, genetics, and molecular biology, with a significant focus on medicine. Within these fields, Nakagama's work is concentrated on key subfields including molecular biology, cancer research, radiology, nuclear medicine and imaging, oncology, and pulmonary and respiratory medicine.

The scientist has contributed to a number of topics related to cancer biology and molecular mechanisms. These main topics include:

  • DNA Repair Mechanisms
  • Carcinogens and Genotoxicity Assessment
  • Wnt/β-catenin signaling in development and cancer
  • Boron Compounds in Chemistry
  • Radiopharmaceutical Chemistry and Applications
  • Cancer, Lipids, and Metabolism
  • Cancer Cells and Metastasis

Nakagama's publication record shows frequent contributions to various academic venues. The prominent journals where their research appears are:

  • Cancer Science (5 publications)
  • Cancer Research (3 publications)
  • Japanese Journal of Clinical Oncology (2 publications)
  • Clinical and Translational Radiation Oncology (1 publication)
  • JNCI Cancer Spectrum (1 publication)

Notable recent papers include:

  • "Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer," published in 2020 in Cancer Research
  • "Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer," published in 2021 in Cancer Science
  • "Scalp angiosarcoma treated with linear accelerator-based boron neutron capture therapy: A report of two patients," published in 2022 in Clinical and Translational Radiation Oncology
  • "Prediction of tissue-of-origin of early stage cancers using serum miRNomes," published in 2022 in JNCI Cancer Spectrum
  • "Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane," published in 2020 in Proceedings of the Japan Academy Series B

Collaborations form an essential part of Nakagama's research activity. Frequent co-authors include:

  • Kazuaki Shimada
  • Daisuke Shiokawa
  • Hiroaki Sakai
  • Hirokazu Ohata
  • Mamoru Kato

The scientist's research touches on several molecular and clinical aspects related to cancer development and treatment, including studies on cancer stem cells, immune evasion, boron neutron capture therapy, and tissue-of-origin prediction using molecular signatures. Their interdisciplinary approach integrates molecular biology techniques with clinical oncology and radiology.

Best Publications

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

    Shinichi Yachida;Sayaka Mizutani;Hirotsugu Shiroma;Satoshi Shiba

  • Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

    Hiroshi Tazawa;Naoto Tsuchiya;Masashi Izumiya;Hitoshi Nakagama

  • Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

    Akihiro Fujimoto;Yasushi Totoki;Tetsuo Abe;Keith A. Boroevich

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish.

    Takashi Sugimura;Keiji Wakabayashi;Hitoshi Nakagama;Minako Nagao

  • Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

    Naoomi Tominaga;Nobuyoshi Kosaka;Makiko Ono;Takeshi Katsuda

  • Frequent inactivation of A20 in B-cell lymphomas

    Motohiro Kato;Masashi Sanada;Itaru Kato;Yasuharu Sato

  • FGF receptors: cancer biology and therapeutics.

    Masaru Katoh;Hitoshi Nakagama

  • Cancer genetics and genomics of human FOX family genes

    Masuko Katoh;Maki Igarashi;Hirokazu Fukuda;Hitoshi Nakagama

  • Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes.

    Mitsuko Masutani;Hiroshi Suzuki;Nobuo Kamada;Miho Watanabe

  • Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial

    Kunihiro Hosono;Hiroki Endo;Hirokazu Takahashi;Michiko Sugiyama

  • Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice.

    Rikako Suzuki;Hiroyuki Kohno;Shigeyuki Sugie;Hitoshi Nakagama

  • Peroxisome proliferator-activated receptor γ ligands suppress colon carcinogenesis induced by azoxymethane in mice☆

    Emi Osawa;Atsushi Nakajima;Koichiro Wada;Satoko Ishimine

  • Metformin suppresses intestinal polyp growth in ApcMin/+ mice

    Ayako Tomimoto;Hiroki Endo;Michiko Sugiyama;Toshio Fujisawa

  • Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway.

    Michiko Sugiyama;Hirokazu Takahashi;Kunihiro Hosono;Hiroki Endo

  • Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer

    Erina Takai;Yasushi Totoki;Hiromi Nakamura;Chigusa Morizane

  • Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase.

    Kunihiro Hosono;Hiroki Endo;Hirokazu Takahashi;Michiko Sugiyama

  • Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition

    Toshio Fujisawa;Hiroki Endo;Ayako Tomimoto;Michiko Sugiyama

  • Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

    Hideki Ogino;Tadashige Nozaki;Akemi Gunji;Miho Maeda

Frequent Co-Authors

Takashi Sugimura
Takashi Sugimura National Cancer Centre
Minako Nagao
Minako Nagao National Cancer Research Institute, UK
Atsushi Nakajima
Atsushi Nakajima Yokohama City University
Hiroshi Suzuki
Hiroshi Suzuki Obihiro University of Agriculture and Veterinary Medicine
Keiji Wakabayashi
Keiji Wakabayashi University of Shizuoka
Tatsuhiro Shibata
Tatsuhiro Shibata University of Tokyo
Takahiro Ochiya
Takahiro Ochiya Tokyo Medical University
Yoichi Taya
Yoichi Taya National University of Singapore
Takehiko Nohmi
Takehiko Nohmi Gifu University
Fumie Hosoda
Fumie Hosoda National Cancer Centre

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