Roger M. Perlmutter

Research.com Recognitions

• 2019 - Distinguished Fellows of the American Association of Immunologists (AAI)
• 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
• 2000 - Fellow of the American Academy of Arts and Sciences

Overview

Best Publications

• A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27Kip1-Deficient Mice

  Matthew L. Fero;Michael Rivkin;Michael Tasch;Peggy Porter

  1845
  Citations

• Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

  Julia M. Turner;Michael H. Brodsky;Bryan A. Irving;Steven D. Levin

  832
  Citations

• Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

  Masanori Hatakeyama;Takeshi Kono;Naoki Kobayashi;Atsuo Kawahara

  736
  Citations

• Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

  Mark W. Appleby;Jane A. Gross;Michael P. Cooke;Steven D. Levin

  723
  Citations

• A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

  Jamey D. Marth;Richard Peet;Richard Peet;Edwin G. Krebs;Roger M. Perlmutter;Roger M. Perlmutter

  691
  Citations

• Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

  Tadaaki Miyazaki;Tadaaki Miyazaki;Zhao Jun Liu;Atsuo Kawahara;Yasuhiro Minami

  524
  Citations

• Selective requirement for MAP kinase activation in thymocyte differentiation.

  Jose Alberola-lla;Jose Alberola-lla;Katherine A. Forbush;Katherine A. Forbush;Rony Seger;Rony Seger;Edwin G. Krebs

  500
  Citations

• Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

  Michael A. Farrar;José Alberola-lla;Roger M. Perlmutter

  466
  Citations

• Developmentally Controlled Expression of Immunoglobulin VH Genes

  Roger M. Perlmutter;John F. Kearney;Sandra P. Chang;Leroy E. Hood

  450
  Citations

• A dominant-negative transgene defines a role for p56lck in thymopoiesis.

  Steven D. Levin;Steven J. Anderson;Katherine A. Forbush;Roger M. Perlmutter

  418
  Citations

• Involvement of p21ras distinguishes positive and negative selection in thymocytes.

  K.A. Swan;J. Alberola-Ila;J.A. Gross;M.W. Appleby

  393
  Citations

• DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

  Jose Alberola-Ila;Satoshi Takaki;James D. Kerner;Roger M. Perlmutter

  384
  Citations

• Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

  Karen E. Chaffin;Chan R. Beals;Thomas M. Wilkie;Katherine A. Forbush

  331
  Citations

• Positive and negative selection invoke distinct signaling pathways.

  José Alberola-Ila;Kristin A. Hogquist;Kathryn A. Swan;Kathryn A. Swan;Michael J. Bevan

  329
  Citations

• The impact of systems approaches on biological problems in drug discovery

  Leroy Hood;Roger M Perlmutter

  321
  Citations

• Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

  S F Ziegler;J D Marth;D B Lewis;R M Perlmutter

  293
  Citations

• Fyn Can Partially Substitute for Lck in T Lymphocyte Development

  Tim Groves;Patricia Smiley;Michael P Cooke;Katherine Forbush

  291
  Citations

• Regulation of lymphocyte function by protein phosphorylation.

  Roger M. Perlmutter;Steven D. Levin;Mark W. Appleby;Steven J. Anderson

  278
  Citations

• Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

  Steven J. Anderson;Kristin M. Abraham;Toshinori Nakayama;Alfred Singer

  238
  Citations

• T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation

  Masakatsu Yamashita;Motoko Kimura;Motoko Kimura;Masato Kubo;Chiori Shimizu

  235
  Citations