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Immunology

D-Index
82
Citations
30110
World Ranking
1485
National Ranking
748

Research.com Recognitions

  • 1995 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Christopher B. Wilson is affiliated with the Bill & Melinda Gates Foundation in the United States and has an extensive publication record in biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology, genetics, and epidemiology, with significant contributions to subfields such as molecular biology, epidemiology, genetics, surgery, and hematology.

Their scientific work covers several key topics including:

  • CRISPR and Genetic Engineering
  • RNA regulation and disease
  • Enzyme Structure and Function
  • RNA Interference and Gene Delivery
  • Nuclear Structure and Function
  • RNA modifications and cancer
  • HVDC Systems and Fault Protection

Christopher B. Wilson has published several notable papers, including:

  • Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020, Nature Biotechnology)
  • In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice (2021, Nature)
  • Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase (2020, Nature Biotechnology)
  • Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning (2020, Cell)
  • Ancient origins of allosteric activation in a Ser-Thr kinase (2020, Science)

Frequent co-authors working with Wilson include:

  • David R. Liu
  • Gregory A. Newby
  • Luke W. Koblan
  • Dorothee Kern
  • Michelle F. Richter

Wilson's research is frequently published in venues such as:

  • Nature Biotechnology
  • Science
  • Antimicrobial Stewardship & Healthcare Epidemiology
  • American Journal of Infection Control
  • European Journal of Surgical Oncology

Wilson's scholarly contributions have been recognized through their election as a Fellow of the American Association for the Advancement of Science (AAAS) in 1995. Their professional profile reflects a sustained engagement with advanced molecular techniques, particularly in gene editing and RNA biology.

Best Publications

  • The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

    Adrian Ozinsky;David M. Underhill;Jason D. Fontenot;Adeline M. Hajjar

  • Regulation of interferon-gamma during innate and adaptive immune responses.

    Jamie R Schoenborn;Christopher B Wilson

  • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

    David M. Underhill;Adrian Ozinsky;Adeline M. Hajjar;Anne Stevens

  • A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

    Peggy P. Lee;David R. Fitzpatrick;Caroline Beard;Heidi K. Jessup

  • Epigenetic control of T-helper-cell differentiation

    Christopher B. Wilson;Emily Rowell;Masayuki Sekimata

  • Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.

    Laurie Jackson-Grusby;Caroline Beard;Richard Possemato;Matthew Tudor

  • Human Toll-like receptor 4 recognizes host-specific LPS modifications

    Adeline M. Hajjar;Robert K. Ernst;Jeff H. Tsai;Christopher B. Wilson

  • T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer.

    Bradley S Cobb;Tatyana Nesterova;Elizabeth A. Thompson;Arnulf Hertweck

  • Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

    Adeline M. Hajjar;D. Shane O’Mahony;Adrian Ozinsky;David M. Underhill

  • Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

    Tobias R. Kollmann;Juliet Crabtree;Annie Rein-Weston;Darren Blimkie

  • Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis.

    Margaret Rosenfeld;Ronald L. Gibson;Sharon McNamara;Julia Emerson

  • Immunologic basis for increased susceptibility of the neonate to infection.

    Christopher B. Wilson

  • Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration.

    Mark A. Kay;Ai Xuan Holterman;Leonard Meuse;Allen Gown

  • Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma.

    Jamie R Schoenborn;Michael O Dorschner;Masayuki Sekimata;Deanna M Santer

  • Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

    Anita Wolfer;Talitha Bakker;Anne Wilson;Michael Nicolas

  • Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes.

    S K Burchett;W M Weaver;J A Westall;A Larsen

  • Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies.

    C B Wilson;J Westall;L Johnston;D B Lewis

  • Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

    L. Penix;W. M. Weaver;Yubin Pang;H. A. Young

  • Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells.

    D B Lewis;C C Yu;J Meyer;B K English

  • Successful readministration of adeno-associated virus vectors to the mouse lung requires transient immunosuppression during the initial exposure.

    Christine L. Halbert;Thomas A. Standaert;Christopher B. Wilson;A. Dusty Miller;A. Dusty Miller

  • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

    D Barr;J Tubb;D Ferguson;A Scaria

Frequent Co-Authors

David B. Lewis
David B. Lewis Stanford University
Arnold L. Smith
Arnold L. Smith Center for Infectious Disease Research
Tobias R. Kollmann
Tobias R. Kollmann Dalhousie University
Mark A. Kay
Mark A. Kay Stanford University
Shawn J. Skerrett
Shawn J. Skerrett University of Washington
Lawrence Corey
Lawrence Corey Fred Hutchinson Cancer Research Center
Samuel I. Miller
Samuel I. Miller University of Washington
Seymour J. Klebanoff
Seymour J. Klebanoff University of Washington
Robert K. Ernst
Robert K. Ernst University of Maryland, Baltimore
Thomas R. Martin
Thomas R. Martin University of Washington

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