2026 David M. Underhill: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	69	2462	2262	1177	1072	162	41821

Overview

David M. Underhill is affiliated with Cedars-Sinai Medical Center in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a focus on molecular biology, immunology, epidemiology, infectious diseases, and surgery.

Their work addresses several key topics, including:

Gut microbiota and health
Antifungal resistance and susceptibility
Probiotics and fermented foods
Pelvic floor disorders treatments
Immune cells in cancer
Inflammasome and immune disorders
Urinary tract infections management

Among recent publications authored or co-authored by David M. Underhill are:

Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans, 2020, Cell
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy, 2021, Cancer Cell
Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice, 2021, Science
Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation, 2023, Science Immunology
Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine, 2022, Cell Host & Microbe

Frequent co-authors collaborating with David M. Underhill include:

Suzanne Devkota
Stephen L. Shiao
Simon Knott
Zachary S. Zumsteg
Karyn S. Eilber

Their research has been published in various scholarly venues, with a notable number of publications in:

bioRxiv (Cold Spring Harbor Laboratory)
Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
The Journal of Immunology
Regular and Young Investigator Award Abstracts
Nature

Best Publications

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.

Fumitaka Hayashi;Kelly D. Smith;Adrian Ozinsky;Thomas R. Hawn;Thomas R. Hawn

4794
Citations
MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES

Alan Aderem;David M. Underhill

3967
Citations
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

Adrian Ozinsky;David M. Underhill;Jason D. Fontenot;Adeline M. Hajjar

2762
Citations
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

Benjamin N. Gantner;Randi M. Simmons;Scott J. Canavera;Shizuo Akira

2387
Citations
Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

Kenichi Shimada;Timothy R. Crother;Justin Karlin;Jargalsaikhan Dagvadorj

2288
Citations
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

David M. Underhill;Adrian Ozinsky;Adeline M. Hajjar;Anne Stevens

1823
Citations
Phagocytosis of Microbes: Complexity in Action

David M. Underhill;Adrian Ozinsky

1458
Citations
Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

Iliyan D. Iliev;Vincent A. Funari;Vincent A. Funari;Kent D. Taylor;Quoclinh Nguyen

1147
Citations
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

David M. Underhill;Adrian Ozinsky;Kelly D. Smith;Alan Aderem

1113
Citations
Toll-like receptors: key mediators of microbe detection.

David M Underhill;Adrian Ozinsky

993
Citations
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

Catherine Werts;Catherine Werts;Richard I. Tapping;John C. Mathison;Tsung Hsien Chuang

963
Citations
Activation of the innate immune receptor Dectin-1 upon formation of a /`phagocytic synapse/'

Helen S. Goodridge;Christopher N. Reyes;Courtney A. Becker;Tamiko R. Katsumoto

932
Citations
Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments

Benjamin N Gantner;Randi M Simmons;David M Underhill

879
Citations
β‐glucan recognition by the innate immune system

Helen S. Goodridge;Andrea J. Wolf;David M. Underhill

828
Citations
The mycobiota: interactions between commensal fungi and the host immune system.

David M. Underhill;Iliyan D. Iliev

806
Citations
Information processing during phagocytosis

David M. Underhill;Helen S. Goodridge

736
Citations
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

David M. Underhill;Eddie Rossnagle;Eddie Rossnagle;Clifford A. Lowell;Clifford A. Lowell;Randi M. Simmons;Randi M. Simmons

640
Citations
Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

Adeline M. Hajjar;D. Shane O’Mahony;Adrian Ozinsky;David M. Underhill

629
Citations
C9orf72 is required for proper macrophage and microglial function in mice

J. G. O’Rourke;L. Bogdanik;A. Yáñez;D. Lall

606
Citations
Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor γ chain to induce innate immune responses

Kota Sato;Xiao Li Yang;Tatsuo Yudate;Jin Sung Chung

549
Citations
Dectin-1 and TLRs Permit Macrophages to Distinguish between Different Aspergillus fumigatus Cellular States

Geoffrey M. Gersuk;David M. Underhill;Liqun Zhu;Kieren A. Marr;Kieren A. Marr

492
Citations
Dectin-1 Stimulation by Candida albicans Yeast or Zymosan Triggers NFAT Activation in Macrophages and Dendritic Cells

Helen S. Goodridge;Randi M. Simmons;David M. Underhill

490
Citations

Frequent Co-Authors

George Y. Liu University of California, San Diego

Alan Aderem Seattle Children's Hospital

Moshe Arditi Cedars-Sinai Medical Center

Michael R. Freeman Cedars-Sinai Medical Center

Dermot P.B. McGovern Cedars-Sinai Medical Center

David A. Hume University of Queensland

Brandon J. Wainwright University of Queensland

Timothy Ravasi Okinawa Institute of Science and Technology

Christine A. Wells University of Melbourne

Sean M. Grimmond University of Melbourne

External Links

Personal website of David M. Underhill

If you think any of the details on this page are incorrect, let us know.

Related Online Degrees & Career Pathways

For those interested in immunology, pursuing related online degrees can open diverse and rewarding career paths. Many healthcare professionals choose to enhance their credentials through programs such as the cheapest online pmhnp certificate programs, which offer affordable options for becoming a psychiatric-mental health nurse practitioner. These programs allow nurses to specialize and work in critical immunology-related fields like neuroimmunology and mental health.

Advanced practice nurses often pursue a doctorate in nursing salary and career data to gauge potential earnings and job growth. A doctoral degree can significantly boost a nurse practitioner’s expertise and salary, especially in specialized immunology areas.

Transitioning roles is common, and resources like acute care nurse practitioner certification guide family nurse practitioners aiming to work in acute and critical care settings, where immunological knowledge is essential.

For accelerated entry into specialized nursing roles, learners often explore the nurse practitioner accelerated program. These programs provide an efficient pathway to becoming a nurse practitioner with a focus on immunology or infectious diseases, paving the way for impactful careers in healthcare and research.