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Neuroscience

D-Index
36
Citations
4688
World Ranking
9048
National Ranking
3822

Overview

George Z. Mentis is affiliated with Columbia University in the United States. Their research primarily focuses on medicine, with significant contributions in biochemistry, genetics, and molecular biology. Their work spans various subfields including genetics, molecular biology, neurology, surgery, and cellular and molecular neuroscience.

Mentz's research topics cover a range of areas centered on neurogenetic and muscular disorders, muscle physiology and disorders, RNA modifications and cancer, genetics and neurodevelopmental disorders, RNA research and splicing, neuroinflammation and neurodegeneration mechanisms, and cardiac structural anomalies and repair.

Their recent publications include:

  • Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit, 2021, Nature Neuroscience
  • Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA, 2021, Science Translational Medicine
  • Molecular correlates of muscle spindle and Golgi tendon organ afferents, 2021, Nature Communications
  • Control of mammalian locomotion by ventral spinocerebellar tract neurons, 2022, Cell
  • SMN controls neuromuscular junction integrity through U7 snRNP, 2022, Cell Reports

Mentz frequently publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain
  • Nature Communications
  • Cell Reports
  • Nature Neuroscience

Frequent coauthors working alongside Mentis are:

  • John G. Pagiazitis
  • Christian M. Simon
  • Livio Pellizzoni
  • Nicolas Delestrée
  • Meaghan Van Alstyne

Best Publications

  • Early Functional Impairment of Sensory-Motor Connectivity in a Mouse Model of Spinal Muscular Atrophy

    George Z. Mentis;Dvir Blivis;Wenfang Liu;Estelle Drobac

  • ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

    Aarti Sharma;Alexander K. Lyashchenko;Lei Lu;Sara Ebrahimi Nasrabady

  • An SMN-dependent U12 splicing event essential for motor circuit function.

    Francesco Lotti;Wendy L. Imlach;Luciano Saieva;Erin S. Beck

  • Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits

    Jay B. Bikoff;Mariano I. Gabitto;Andre F. Rivard;Estelle Drobac

  • Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit

    Meaghan Van Alstyne;Ivan Tattoli;Nicolas Delestrée;Yocelyn Recinos

  • Noncholinergic excitatory actions of motoneurons in the neonatal mammalian spinal cord

    George Z. Mentis;Francisco J. Alvarez;Agnes Bonnot;Dannette S. Richards

  • Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.

    Emily V Fletcher;Christian M Simon;John G Pagiazitis;Joshua I Chalif

  • The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA.

    Aleksandra Vukojicic;Nicolas Delestrée;Emily V. Fletcher;John G. Pagiazitis

  • Reduced gap junctional coupling leads to uncorrelated motor neuron firing and precocious neuromuscular synapse elimination

    Kirkwood E. Personius;Qiang Chang;George Z. Mentis;Michael J. O'Donovan

  • Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA

    Lingling Kong;David O. Valdivia;Christian M. Simon;Cera W. Hassinan

  • Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody

    Sarah Cantor;Wei Zhang;Nicolas Delestrée;Leonor Remédio

  • Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy

    Christian M. Simon;Ya Dai;Meaghan Van Alstyne;Charalampia Koutsioumpa

  • Molecular correlates of muscle spindle and Golgi tendon organ afferents

    Unknown

  • SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3′-End Formation of Histone mRNAs

    Sarah Tisdale;Francesco Lotti;Luciano Saieva;James P. Van Meerbeke

  • Locomotor-like activity generated by the neonatal mouse spinal cord.

    Agnès Bonnot;Patrick J Whelan;George Z Mentis;Michael J O’Donovan

  • Primary afferent synapses on developing and adult Renshaw cells.

    George Z. Mentis;Valerie C. Siembab;Ricardo Zerda;Michael J. O'Donovan

  • Dual personality of GABA/glycine-mediated depolarizations in immature spinal cord

    Céline Jean-Xavier;George Z. Mentis;Michael J. O'Donovan;Daniel Cattaert

  • Motoneurons destined to die are rescued by blocking n-methyl-d-aspartate receptors by MK-801

    G.Z. Mentis;L. Greensmith;G. Vrbová

  • Target Selection of Proprioceptive and Motor Axon Synapses on Neonatal V1-Derived Ia Inhibitory Interneurons and Renshaw Cells

    Valerie C. Siembab;Courtney A. Smith;Laskaro Zagoraiou;Maria C. Berrocal

  • Spatiotemporal pattern of motoneuron activation in the rostral lumbar and the sacral segments during locomotor-like activity in the neonatal mouse spinal cord.

    Agnès Bonnot;Patrick J. Whelan;George Z. Mentis;Michael J. O'Donovan

  • Blockade of N-methyl-D-aspartate receptors by MK-801 (dizocilpine maleate) rescues motoneurones in developing rats.

    L. Greensmith;G.Z. Mentis;G. Vrbová

Frequent Co-Authors

Michael J. O'Donovan
Michael J. O'Donovan National Institutes of Health
Francisco J. Alvarez
Francisco J. Alvarez Emory University
Gerta Vrbová
Gerta Vrbová University College London
Angel M. Pastor
Angel M. Pastor University of Seville
Teresa A. Milner
Teresa A. Milner Cornell University
Patrick J. Whelan
Patrick J. Whelan University of Calgary
Thomas M. Jessell
Thomas M. Jessell Columbia University
Christopher E. Henderson
Christopher E. Henderson Biogen (United States)
Anna Simon
Anna Simon Christian Medical College & Hospital
Karen P. Steel
Karen P. Steel King's College London

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