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Nobuyuki Takakura

Nobuyuki Takakura

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
19109
World Ranking
7709
National Ranking
519

Overview

Nobuyuki Takakura is affiliated with Osaka University in Japan and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their research mainly focuses on molecular biology and cancer research, with notable work also in immunology, cellular and molecular neuroscience, and surgery.

Their research interests cover a range of topics including:

  • Angiogenesis and VEGF in Cancer
  • Apelin-related biomedical research
  • Cancer, Hypoxia, and Metabolism
  • Nuclear Receptors and Signaling
  • Zebrafish Biomedical Research Applications
  • Axon Guidance and Neuronal Signaling
  • Epigenetics and DNA Methylation

Takakura has published in several scientific venues, with frequent publications in:

  • Scientific Reports
  • Orthopaedic Proceedings
  • Nature Communications
  • Journal of Medicinal Chemistry
  • Angiogenesis

Notable recent papers include:

  • "Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells," 2020, International Immunology
  • "Identification of the first highly selective inhibitor of human lactate dehydrogenase B," 2021, Scientific Reports
  • "The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis," 2020, Nature Communications
  • "Japanese clinical practice guidelines for vascular anomalies 2017," 2020, Japanese Journal of Radiology
  • "Design and Identification of a GPR40 Full Agonist (SCO-267) Possessing a 2-Carbamoylphenyl Piperidine Moiety," 2020, Journal of Medicinal Chemistry

Their frequent coauthors reflect collaborations with researchers from various specialties and include:

  • Hiroyasu Kidoya
  • Fumitaka Muramatsu
  • Weizhen Jia
  • Hisamichi Naito
  • Fitriana Nur Rahmawati

Best Publications

  • Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

    Takashi Nagasawa;Seiichi Hirota;Kazunobu Tachibana;Nobuyuki Takakura

  • A role for hematopoietic stem cells in promoting angiogenesis.

    Nobuyuki Takakura;Toshio Watanabe;Souichi Suenobu;Yoshihiro Yamada

  • A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

    Hirofumi Misu;Toshinari Takamura;Hiroaki Takayama;Hiroto Hayashi

  • Cyclic AMP Potentiates Vascular Endothelial Cadherin-Mediated Cell-Cell Contact To Enhance Endothelial Barrier Function through an Epac-Rap1 Signaling Pathway

    Shigetomo Fukuhara;Atsuko Sakurai;Hideto Sano;Akiko Yamagishi

  • Identification and functional analysis of endothelial tip cell–enriched genes

    Raquel del Toro;Raquel del Toro;Claudia Prahst;Claudia Prahst;Thomas Mathivet;Thomas Mathivet;Geraldine Siegfried

  • Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

    Shigetomo Fukuhara;Keisuke Sako;Takashi Minami;Kazuomi Noda

  • Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

    Keiichi Kumasawa;Masahito Ikawa;Hiroyasu Kidoya;Hidetoshi Hasuwa

  • Critical Role of the TIE2 Endothelial Cell Receptor in the Development of Definitive Hematopoiesis

    Nobuyuki Takakura;Xu Ling Huang;Takeshi Naruse;Isao Hamaguchi

  • STEPWISE REQUIREMENT OF C-KIT TYROSINE KINASE IN MOUSE OVARIAN FOLLICLE DEVELOPMENT

    Hisahiro Yoshida;Nobuyuki Takakura;Hiroshi Kataoka;Takahiro Kunisada

  • Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

    Takashi Satoh;Hiroyasu Kidoya;Hisamichi Naito;Masahiro Yamamoto

  • Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis

    Hiroyasu Kidoya;Masaya Ueno;Yoshihiro Yamada;Naoki Mochizuki

  • PDGF mediates a neuron-astrocyte interaction in the developing retina

    Marcus Fruttiger;Andrew R Calver;Winfried H Krüger;Hardeep S Mudhar

  • Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells

    Hiroshi Kataoka;Nobuyuki Takakura;Satomi Nishikawa;Kunihiro Tsuchida

  • Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34.

    K Kita;K Nakase;H Miwa;M Masuya

  • Mice Homozygous for a Truncated Form of CREB-Binding Protein Exhibit Defects in Hematopoiesis and Vasculo-angiogenesis

    Yuichi Oike;Nobuyuki Takakura;Nobuyuki Takakura;Akira Hata;Akira Hata;Tadashi Kaname;Tadashi Kaname

  • Functional Blockade of Platelet-Derived Growth Factor Receptor-β but Not of Receptor-α Prevents Vascular Smooth Muscle Cell Accumulation in Fibrous Cap Lesions in Apolipoprotein E–Deficient Mice

    Hideto Sano;Tetsuo Sudo;Masayuki Yokode;Toshinori Murayama

  • Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

    Kazuaki Yoshioka;Kotaro Yoshida;Hong Cui;Tomohiko Wakayama

  • Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis.

    Kazunari Koga;Tatemi Todaka;Motohiro Morioka;Jun-ichiro Hamada

  • VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis.

    Koichi Hamada;Yuichi Oike;Nobuyuki Takakura;Yasuhiro Ito

  • PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5.

    N. Takakura;H. Yoshida;Y. Ogura;H. Kataoka

Frequent Co-Authors

Toshio Suda
Toshio Suda National University of Singapore
Yuichi Oike
Yuichi Oike Kumamoto University
Naoki Mochizuki
Naoki Mochizuki National Cerebral and Cardiovascular Center
Shizuo Akira
Shizuo Akira Osaka University
Masahide Asano
Masahide Asano Kyoto University
Eiichi Morii
Eiichi Morii Osaka University
Masatsugu Ema
Masatsugu Ema Shiga University of Medical Science
George D. Yancopoulos
George D. Yancopoulos Regeneron (United States)
Akiyoshi Fukamizu
Akiyoshi Fukamizu University of Tsukuba

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