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Takashi Nagasawa

Takashi Nagasawa

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
32443
World Ranking
6125
National Ranking
393

Overview

Takashi Nagasawa is affiliated with Osaka University in Japan and has made significant contributions across the fields of Medicine and Immunology and Microbiology. Their research primarily focuses on hematology, immunology, oncology, genetics, and molecular biology, with substantial work in the subfields of hematopoietic stem cell transplantation, mesenchymal stem cell research, acute myeloid leukemia research, immune cell function and interaction, immunotherapy and immune responses, chemokine receptors and signaling, and T-cell and B-cell immunology.

Their recent publications include:

  • A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration (2020, Nature Communications)
  • Remodeling of light and dark zone follicular dendritic cells governs germinal center responses (2020, Nature Immunology)
  • Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions (2021, The Journal of Experimental Medicine)
  • Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation (2021, The Journal of Experimental Medicine)
  • Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion (2020, Blood)

Among frequent collaborators in their research are Yoshiki Omatsu, César Nombela-Arrieta, Stephan Isringhausen, Álvaro Gomariz, and Tatsuki Sugiyama.

Nagasawa has published in various notable scientific venues, including:

  • Nature Communications
  • Cell Reports
  • The Journal of Experimental Medicine
  • Food Science and Technology Research
  • Experimental Hematology

In addition to journal articles, Nagasawa has contributed to book publications, including a work titled Bone Marrow Niche published by Springer Science+Business Media in 2021.

The scientist's research topics represent diverse aspects of cellular and molecular mechanisms related to stem cells and immune system function. Major topics of inquiry include hematopoietic stem cell transplantation, mesenchymal stem cell research, acute myeloid leukemia, immune cell function and interaction, immunotherapy and immune responses, chemokine receptor signaling, and lymphocyte immunology.

Best Publications

  • Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

    Takashi Nagasawa;Seiichi Hirota;Kazunobu Tachibana;Nobuyuki Takakura

  • Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches

    Tatsuki Sugiyama;Hiroshi Kohara;Mamiko Noda;Takashi Nagasawa

  • Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

    Qing Ma;Dan Jones;Paul R. Borghesani;Rosalind A. Segal

  • The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.

    Kazunobu Tachibana;Seiichi Hirota;Hisashi Iizasa;Hisahiro Yoshida

  • CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

    Adam Greenbaum;Yen-Michael S. Hsu;Ryan B. Day;Laura G. Schuettpelz

  • Molecular cloning and structure of a pre-B-cell growth-stimulating factor

    Takashi Nagasawa;Hitoshi Kikutani;Tadamitsu Kishimoto

  • The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

    Yoshiki Omatsu;Tatsuki Sugiyama;Hiroshi Kohara;Gen Kondoh

  • Cellular niches controlling B lymphocyte behavior within bone marrow during development

    Koji Tokoyoda;Takeshi Egawa;Tatsuki Sugiyama;Byung Il Choi

  • Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

    María Casanova-Acebes;Christophe Pitaval;Linnea A. Weiss;César Nombela-Arrieta

  • Stromal cell–derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model

    Toshiyuki Kitaori;Hiromu Ito;Edward M. Schwarz;Ryosuke Tsutsumi

  • CXCR4 Regulates Interneuron Migration in the Developing Neocortex

    Ralf K. Stumm;Chun Zhou;Toshiaki Ara;Françoise Lazarini

  • Microenvironmental niches in the bone marrow required for B-cell development

    Takashi Nagasawa

  • A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection

    Tsutomu Murakami;Toshihiro Nakajima;Yoshio Koyanagi;Kazunobu Tachibana

  • Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin

    Takashi Nagasawa;Toshihiro Nakajima;Kazunobu Tachibana;Hisashi Iizasa

  • Long-Term Hematopoietic Stem Cells Require Stromal Cell-Derived Factor-1 for Colonizing Bone Marrow during Ontogeny

    Toshiaki Ara;Koji Tokoyoda;Tatsuki Sugiyama;Takeshi Egawa

  • Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1)

    Toshiaki Ara;Yuri Nakamura;Takeshi Egawa;Tatsuki Sugiyama

  • A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

    Noriaki Ono;Wanida Ono;Takashi Nagasawa;Henry M. Kronenberg

  • Paranodal junction formation and spermatogenesis require sulfoglycolipids.

    Koichi Honke;Yukie Hirahara;Jeffrey Dupree;Kinuko Suzuki

  • Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

    Tetsuji Naka;Tomoshige Matsumoto;Masashi Narazaki;Minoru Fujimoto

  • Resting zone of the growth plate houses a unique class of skeletal stem cells

    Koji Mizuhashi;Wanida Ono;Yuki Matsushita;Naoko Sakagami

Frequent Co-Authors

Tadamitsu Kishimoto
Tadamitsu Kishimoto Osaka University
Nobutaka Fujii
Nobutaka Fujii Kyoto University
Nobuaki Yoshida
Nobuaki Yoshida University of Tokyo
Toshio Suda
Toshio Suda National University of Singapore
Koichi Ikuta
Koichi Ikuta Kyoto University
Paul S. Frenette
Paul S. Frenette Albert Einstein College of Medicine
Daniel C. Link
Daniel C. Link Washington University in St. Louis
Yuzuru Kanakura
Yuzuru Kanakura Osaka University
Fabienne Mackay
Fabienne Mackay QIMR Berghofer Medical Research Institute
Fujio Murakami
Fujio Murakami Osaka University

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