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Immunology

D-Index
43
Citations
8479
World Ranking
4827
National Ranking
2166

Overview

Dawn C. Newcomb is affiliated with Vanderbilt University Medical Center in the United States. Their research has contributed extensively to the fields of Medicine and Immunology and Microbiology, with notable work in subfields including Physiology, Immunology, Pulmonary and Respiratory Medicine, Surgery, and Epidemiology.

The primary focus of Newcomb's research centers on asthma and respiratory diseases, IL-33, ST2, and ILC pathways, neonatal respiratory health, eosinophilic esophagitis, immune cell function and interaction, respiratory viral infections, and chronic obstructive pulmonary disease (COPD) research.

Notable recent papers include:

  • Sex and gender in asthma, 2021, European Respiratory Review
  • MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function, 2021, Immunity
  • TSLP and IL-33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation, 2020, Allergy
  • Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD, 2020, Journal of Clinical Investigation
  • Estrogen receptor-α signaling increases allergen-induced IL-33 release and airway inflammation, 2020, Allergy

Frequent co-authors in their collaborative work include:

  • R. Stokes Peebles
  • Nowrin U. Chowdhury
  • Allison E. Norlander
  • Shinji Toki
  • Weisong Zhou

Newcomb has published repeatedly in several venues, with the highest number of publications appearing in:

  • The Journal of Immunology
  • Journal of Allergy and Clinical Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Respiratory and Critical Care Medicine
  • Allergy

Best Publications

  • Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

    Marc O. Johnson;Marc O. Johnson;Melissa M. Wolf;Matthew Z. Madden;Gabriela Andrejeva

  • Mechanisms Driving Gender Differences in Asthma

    Hubaida Fuseini;Dawn C. Newcomb;Dawn C. Newcomb

  • Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

    William E. Lawson;Dong-Sheng Cheng;Amber L. Degryse;Harikrishna Tanjore

  • Sex and gender in asthma.

    Nowrin U. Chowdhury;Vamsi P. Guntur;Dawn C. Newcomb;Dawn C. Newcomb;Michael E. Wechsler

  • Th17-mediated inflammation in asthma

    Dawn C Newcomb;R Stokes Peebles

  • PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

    Lindsay J. Celada;Jonathan A. Kropski;Jose D. Herazo-Maya;Weifeng Luo

  • Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation.

    Jacqueline Yvonne Cephus;Matthew T. Stier;Hubaida Fuseini;Jeffrey A. Yung

  • Sex Bias in Asthma Prevalence and Pathogenesis.

    Ruchi Shah;Dawn C. Newcomb;Dawn C. Newcomb

  • Differential Pathogenesis of Respiratory Syncytial Virus Clinical Isolates in BALB/c Mice

    Kate L. Stokes;Michael H. Chi;Kaori Sakamoto;Dawn C. Newcomb

  • Hormones, sex, and asthma.

    Jeffrey A. Yung;Hubaida Fuseini;Dawn C. Newcomb

  • MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

    Ayaka Sugiura;Gabriela Andrejeva;Kelsey Voss;Darren R. Heintzman

  • Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

    Matthew T. Stier;Melissa H. Bloodworth;Shinji Toki;Dawn C. Newcomb

  • A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction

    Martin L. Moore;Michael H. Chi;Cindy Luongo;Nicholas W. Lukacs

  • H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression

    Umadevi S. Sajjan;Yue Jia;Dawn C. Newcomb;J. Kelley Bentley

  • IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow

    Matthew T. Stier;Jian Zhang;Kasia Goleniewska;Jacqueline Y. Cephus

  • A Functional IL-13 Receptor is Expressed on Polarized Murine CD4+ Th17 Cells and IL-13 Signaling Attenuates Th17 Cytokine Production

    Dawn C. Newcomb;Weisong Zhou;Martin L. Moore;Kasia Goleniewska

  • Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.

    Weisong Zhou;Shinji Toki;Jian Zhang;Kasia Goleniewksa

  • Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma.

    Dawn C. Newcomb;Jacqueline Yvonne Cephus;Madison G. Boswell;John M. Fahrenholz

  • Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.

    Hubaida Fuseini;Jeffrey A. Yung;Jacqueline Yvonne Cephus;Jian Zhang

  • Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice.

    Dawn C. Newcomb;Umadevi S. Sajjan;Deepti R. Nagarkar;Qiong Wang

  • Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production

    Dawn C. Newcomb;Madison G. Boswell;Weisong Zhou;Matthew M. Huckabee

Frequent Co-Authors

R. Stokes Peebles
R. Stokes Peebles Vanderbilt University
Kelli L. Boyd
Kelli L. Boyd Vanderbilt University Medical Center
Timothy S. Blackwell
Timothy S. Blackwell University of Michigan–Ann Arbor
Martin L. Moore
Martin L. Moore Emory University
Jay K. Kolls
Jay K. Kolls Tulane University
Tina V. Hartert
Tina V. Hartert Vanderbilt University Medical Center
Garret A. FitzGerald
Garret A. FitzGerald University of Pennsylvania
Jeffrey C. Rathmell
Jeffrey C. Rathmell Vanderbilt University Medical Center
William Lawson
William Lawson Stony Brook University
Nicholas W. Lukacs
Nicholas W. Lukacs University of Michigan–Ann Arbor

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