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D-Index & Metrics

Medicine

D-Index
86
Citations
26337
World Ranking
14154
National Ranking
7170

Research.com Recognitions

  • 2000 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Kathryn B. Horwitz is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research focuses on biochemistry, genetics, and molecular biology, with additional work in medicine. The scientist's investigations delve into subfields including genetics, molecular biology, oncology, cancer research, and pathology and forensic medicine.

Horwitz's primary research topics encompass estrogen and related hormone effects, PI3K/AKT/mTOR signaling in cancer, Wnt/β-catenin signaling in development and cancer, cancer cells and metastasis, cancer hypoxia and metabolism, microtubule and mitosis dynamics, and phytoestrogen effects and research.

Frequent coauthors working alongside Horwitz include Carol A. Sartorius, Heather M. Brechbuhl, Alexander Barrett, Etana Kopin, and Jaime Hagen.

Key recent publications include:

  • 90 YEARS OF PROGESTERONE: Progesterone and progesterone receptors in breast cancer: past, present, future (2020, Journal of Molecular Endocrinology)
  • Fibroblast subtypes define a metastatic matrisome in breast cancer (2020, JCI Insight)
  • Response to: Progesterone and breast cancer pathogenesis (2020, Journal of Molecular Endocrinology)
  • Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features (2020, UNC Libraries)

The primary publication venues for Horwitz's work are:

  • Journal of Molecular Endocrinology
  • JCI Insight
  • UNC Libraries

Kathryn B. Horwitz was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2000.

Best Publications

  • Nuclear Receptor Coactivators and Corepressors

    K B Horwitz;T A Jackson;D L Bain;J K Richer

  • Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.

    K B Horwitz;W L McGuire

  • Phytoestrogen interaction with estrogen receptors in human breast cancer cells.

    Pierre M. Martin;Kathryn B. Horwitz;Dale S. Ryan;William L. McGUIRE

  • Predicting response to endocrine therapy in human breast cancer: a hypothesis.

    K B Horwitz;W L McGuire

  • Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells.

    Jennifer K. Richer;Britta M. Jacobsen;Nicole G. Manning;M. Greg Abel

  • Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.

    Carol A. Lange;Tianjie Shen;Kathryn B. Horwitz

  • The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT

    Twila A. Jackson;Jennifer K. Richer;David L. Bain;Glenn S. Takimoto

  • Estrogen Control of Progesterone Receptor in Human Breast Cancer: Role of Estradiol and Antiestrogen*

    Kathryn B. Horwitz;Yoshihiro Koseki;William L. McGUIRE

  • MCF-7: A human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors

    K.B. Horwitz;M.E. Costlow;W.L. McGuire

  • CURRENT STATUS OF ESTROGEN AND PROGESTERONE RECEPTORS IN BREAST CANCER

    W. L. McGuire;K. B. Horwitz;O. H. Pearson;A. Segaloff

  • Nuclear mechanisms of estrogen action. Effects of estradiol and anti-estrogens on estrogen receptors and nuclear receptor processing.

    K B Horwitz;W L McGuire

  • Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors.

    Lin Tung;Mohamed Kamel Mohamed;J. P. Hoeffler;G. S. Takimoto

  • Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300.

    Gareth I. Owen;Jennifer K. Richer;Lin Tung;Glenn Takimoto

  • Steroid receptor analyses of nine human breast cancer cell lines.

    Kathryn B. Horwitz;David T. Zava;Arulasanam K. Thilagar;Erling M. Jensen

  • A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform.

    C. A. Sartorius;M. Y. Melville;A. R. Hovland;Lin Tung

  • Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1

    Steve D. Groshong;Gareth I. Owen;Bryn Grimison;Irene E. Schauer

  • Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance

    Kathryn B. Horwitz;Mary B. Mockus;Bruce A. Lessey

  • In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation.

    Horwitz Kb;Alexander Ps

  • Canine vascular tissues are targets for androgens, estrogens, progestins, and glucocorticoids.

    Kathryn B. Horwitz;Lawrence D. Horwitz

  • PREDICTING RESPONSE TO ENDOCRINE THERAPY IN HUMAN BREAST CANCER: A HYPOTHESIS

    Kathryn B. Horwitz;William L. McGUIRE;Olof H. Pearson;Albert Segaloff

Frequent Co-Authors

Jennifer K. Richer
Jennifer K. Richer University of Colorado Anschutz Medical Campus
William L. McGuire
William L. McGuire The University of Texas Health Science Center at San Antonio
Virginia F. Borges
Virginia F. Borges University of Colorado Boulder
Dean P. Edwards
Dean P. Edwards Baylor College of Medicine
Anthony D. Elias
Anthony D. Elias University of Colorado Boulder
D. Craig Allred
D. Craig Allred The University of Texas Health Science Center at San Antonio
Paul A. Bunn
Paul A. Bunn University of Colorado Boulder
Jan J. Brosens
Jan J. Brosens University of Warwick
James L. McManaman
James L. McManaman University of Colorado Denver
David O. Toft
David O. Toft Mayo Clinic

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