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David O. Toft

David O. Toft

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
29725
World Ranking
2692
National Ranking
1397

Overview

David O. Toft is a researcher affiliated with the Mayo Clinic in the United States, specializing in the interdisciplinary fields of biochemistry, genetics, molecular biology, and computer science. Their work spans both experimental and computational approaches, focusing primarily on molecular and computational biology.

Their recent publication history includes a paper titled "Structures of the N-Terminal and Middle Domains of E. coli Hsp90 and Conformation Changes upon ADP Binding", published in 2021 in the venue UNC Libraries. This work addresses structural biology aspects of heat shock proteins, specifically the Escherichia coli Hsp90 protein, and details biochemical mechanisms related to ADP binding.

Research topics central to their work include:

  • Heat shock proteins research
  • ATP Synthase and ATPases Research
  • Computational Drug Discovery Methods

These topics reflect an overlap of biochemical mechanisms and computational methods applied to molecular systems.

The subfields of study contributing to their research are:

  • Molecular Biology
  • Computational Theory and Mathematics

Frequent coauthors collaborating with David O. Toft include:

  • Qing Huai
  • Huanchen Wang
  • Yudong Liu
  • Hwa-Young Kim
  • Hengming Ke

Collaborations indicate a team approach involving multiple contributors from related scientific backgrounds.

Among publication venues, UNC Libraries is a notable platform for their work. Their contributions to this venue solidify their presence in accessible research dissemination, particularly related to heat shock proteins and ATPase activity studies.

Best Publications

  • Steroid receptor interactions with heat shock protein and immunophilin chaperones.

    William B. Pratt;David O. Toft

  • Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.

    William B. Pratt;David O. Toft

  • A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization

    David Toft;Jack Gorski

  • The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

    James P. Grenert;William P. Sullivan;Patrick Fadden;Timothy A.J. Haystead

  • Functional requirement of p23 and Hsp90 in telomerase complexes

    Shawn E. Holt;Shawn E. Holt;Dara L. Aisner;Joseph Baur;Valerie M. Tesmer

  • Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

    E R Sanchez;D O Toft;M J Schlesinger;W B Pratt

  • Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.

    Theodor W. Schulte;Shiro Akinaga;Shiro Soga;William Sullivan

  • The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.

    Sara J. Felts;Barbara A.L. Owen;PhuongMai Nguyen;Jane Trepel

  • An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

    Bradley T. Scroggins;Kenneth Robzyk;Dongxia Wang;Monica G. Marcu

  • Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23

    Brian C. Freeman;David O. Toft;Richard I. Morimoto

  • A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

    S Schuh;W Yonemoto;J Brugge;V J Bauer

  • Hepadnavirus assembly and reverse transcription require a multi‐component chaperone complex which is incorporated into nucleocapsids

    Jianming Hu;David O. Toft;Christoph Seeger

  • Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Advanced Cancer

    Matthew P. Goetz;David Toft;Joel Reid;Matthew Ames

  • Response of human breast cancer cells to heat shock and chemotherapeutic drugs.

    Daniel R. Ciocca;Suzanne A. W. Fuqua;Sarah Lock-Lim;David O. Toft

  • Inhibition of progesterone receptor activation by sodium molybdate.

    Hideo Nishigori;David Toft

  • Nucleotides and Two Functional States of hsp90

    William Sullivan;Bridget Stensgard;George Caucutt;Bence Bartha

  • Molecular Cloning of the Chicken Progesterone Receptor

    Orla M. Conneely;William P. Sullivan;David O. Toft;Mariel Birnbaumer

  • Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins.

    D F Smith;L E Faber;D O Toft

  • Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.

    Yongle Guo;Toumy Guettouche;Mary Fenna;Frank Boellmann

  • Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.

    E R Sanchez;S Meshinchi;W Tienrungroj;M J Schlesinger

Frequent Co-Authors

William J. Sullivan
William J. Sullivan Indiana University
William T. Schrader
William T. Schrader Baylor College of Medicine
Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
Orla M. Conneely
Orla M. Conneely Baylor College of Medicine
William B. Pratt
William B. Pratt University of Michigan–Ann Arbor
Alan D. W. Dobson
Alan D. W. Dobson University College Cork
Dean P. Edwards
Dean P. Edwards Baylor College of Medicine
Larry M. Karnitz
Larry M. Karnitz Mayo Clinic

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