World's Best Scientists 2026 revealed!
David O. Toft

David O. Toft

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
29725
World Ranking
2691
National Ranking
1396

David O. Toft publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where David O. Toft sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 182 publications — 42nd percentile

42% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

David O. Toft D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where David O. Toft sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 88 D-Index — 87th percentile

87% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

David O. Toft is a researcher affiliated with the Mayo Clinic in the United States, specializing in the interdisciplinary fields of biochemistry, genetics, molecular biology, and computer science. Their work spans both experimental and computational approaches, focusing primarily on molecular and computational biology.

Their recent publication history includes a paper titled "Structures of the N-Terminal and Middle Domains of E. coli Hsp90 and Conformation Changes upon ADP Binding", published in 2021 in the venue UNC Libraries. This work addresses structural biology aspects of heat shock proteins, specifically the Escherichia coli Hsp90 protein, and details biochemical mechanisms related to ADP binding.

Research topics central to their work include:

  • Heat shock proteins research
  • ATP Synthase and ATPases Research
  • Computational Drug Discovery Methods

These topics reflect an overlap of biochemical mechanisms and computational methods applied to molecular systems.

The subfields of study contributing to their research are:

  • Molecular Biology
  • Computational Theory and Mathematics

Frequent coauthors collaborating with David O. Toft include:

  • Qing Huai
  • Huanchen Wang
  • Yudong Liu
  • Hwa-Young Kim
  • Hengming Ke

Collaborations indicate a team approach involving multiple contributors from related scientific backgrounds.

Among publication venues, UNC Libraries is a notable platform for their work. Their contributions to this venue solidify their presence in accessible research dissemination, particularly related to heat shock proteins and ATPase activity studies.

Best Publications

  • Steroid receptor interactions with heat shock protein and immunophilin chaperones.

    William B. Pratt;David O. Toft

  • Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.

    William B. Pratt;David O. Toft

  • A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization

    David Toft;Jack Gorski

  • The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

    James P. Grenert;William P. Sullivan;Patrick Fadden;Timothy A.J. Haystead

  • Functional requirement of p23 and Hsp90 in telomerase complexes

    Shawn E. Holt;Shawn E. Holt;Dara L. Aisner;Joseph Baur;Valerie M. Tesmer

  • Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

    E R Sanchez;D O Toft;M J Schlesinger;W B Pratt

  • Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.

    Theodor W. Schulte;Shiro Akinaga;Shiro Soga;William Sullivan

  • The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.

    Sara J. Felts;Barbara A.L. Owen;PhuongMai Nguyen;Jane Trepel

  • An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

    Bradley T. Scroggins;Kenneth Robzyk;Dongxia Wang;Monica G. Marcu

  • Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23

    Brian C. Freeman;David O. Toft;Richard I. Morimoto

  • A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

    S Schuh;W Yonemoto;J Brugge;V J Bauer

  • Hepadnavirus assembly and reverse transcription require a multi‐component chaperone complex which is incorporated into nucleocapsids

    Jianming Hu;David O. Toft;Christoph Seeger

  • Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Advanced Cancer

    Matthew P. Goetz;David Toft;Joel Reid;Matthew Ames

  • Response of human breast cancer cells to heat shock and chemotherapeutic drugs.

    Daniel R. Ciocca;Suzanne A. W. Fuqua;Sarah Lock-Lim;David O. Toft

  • Inhibition of progesterone receptor activation by sodium molybdate.

    Hideo Nishigori;David Toft

  • Nucleotides and Two Functional States of hsp90

    William Sullivan;Bridget Stensgard;George Caucutt;Bence Bartha

  • Molecular Cloning of the Chicken Progesterone Receptor

    Orla M. Conneely;William P. Sullivan;David O. Toft;Mariel Birnbaumer

  • Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins.

    D F Smith;L E Faber;D O Toft

  • Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.

    Yongle Guo;Toumy Guettouche;Mary Fenna;Frank Boellmann

  • Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.

    E R Sanchez;S Meshinchi;W Tienrungroj;M J Schlesinger

Frequent Co-Authors

William J. Sullivan
William J. Sullivan Indiana University
William T. Schrader
William T. Schrader Baylor College of Medicine
Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
Orla M. Conneely
Orla M. Conneely Baylor College of Medicine
William B. Pratt
William B. Pratt University of Michigan–Ann Arbor
Alan D. W. Dobson
Alan D. W. Dobson University College Cork
Dean P. Edwards
Dean P. Edwards Baylor College of Medicine
Larry M. Karnitz
Larry M. Karnitz Mayo Clinic

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