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Biology and Biochemistry

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48
Citations
9224
World Ranking
18343
National Ranking
7489

Overview

Robert M. Grainger is affiliated with the University of Virginia in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a focused contribution to several subfields including Molecular Biology, Genetics, Aging, Cell Biology, and Radiology, Nuclear Medicine and Imaging.

The main topics covered by their work include:

  • CRISPR and Genetic Engineering
  • Developmental Biology and Gene Regulation
  • Genetics and Neurodevelopmental Disorders
  • Congenital Heart Defects Research
  • Genomics and Rare Diseases
  • Pluripotent Stem Cells Research
  • Genetics, Aging, and Longevity in Model Organisms

Recent publications by Robert M. Grainger reflect a focus on developmental biology and gene editing techniques, especially in the study of amphibian models such as Xenopus species. Notable papers include:

  • "Simple embryo injection of long single-stranded donor templates with the CRISPR/Cas9 system leads to homology-directed repair in Xenopus tropicalis and Xenopus laevis", 2020, genesis
  • "Modelling human genetic disorders in Xenopus tropicalis", 2024, Disease Models & Mechanisms
  • "Genetics and Gene Editing Methods in Xenopus laevis and Xenopus tropicalis", 2022, Cold Spring Harbor Protocols
  • "Elucidating the framework for specification and determination of the embryonic retina", 2020, Experimental Cell Research
  • "Six3 acts independently of Pax6 to provide an essential contribution to lens development", 2023, bioRxiv (Cold Spring Harbor Laboratory)

Their collaborations include frequent co-authorships with several researchers, including Takuya Nakayama, Matthew Guille, Marilyn Fisher, Helen Rankin Willsey, and Eleanor G. Seaby. These collaborations reflect a network of research partnerships often centered on genetic engineering and developmental biology themes.

In terms of publication venues, Robert M. Grainger's work is regularly featured in:

  • Cold Spring Harbor Protocols
  • Disease Models & Mechanisms
  • genesis
  • Experimental Cell Research
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Early development of Xenopus laevis : a laboratory manual

    Hazel L. Sive;Robert M. Grainger;Richard M. Harland

  • The genome of the western clawed frog xenopus tropicalis

    Uffe Hellsten;Richard M. Harland;Michael J. Gilchrist;David Hendrix

  • Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis.

    Takuya Nakayama;Margaret B. Fish;Marilyn Fisher;Jamina Oomen-Hajagos

  • Embryonic lens induction: shedding light on vertebrate tissue determination.

    Robert M. Grainger

  • Xenopus research: metamorphosed by genetics and genomics

    Richard M. Harland;Robert M. Grainger

  • Disruption of Autoregulatory Feedback by a Mutation in a Remote, Ultraconserved PAX6 Enhancer Causes Aniridia

    Shipra Bhatia;Hemant Bengani;Margaret Fish;Alison Brown

  • Conservative assembly and segregation of nucleosomal histories

    I.Michael Leffak;Robert Grainger;Harold Weintraub

  • Frog genetics: Xenopus tropicalis jumps into the future

    Enrique Amaya;Martin F Offield;Robert M Grainger

  • Xenopus, the Next Generation : X. tropicalis Genetics and Genomics

    Nicolas Hirsch;Lyle B. Zimmerman;Robert M. Grainger

  • A Newly Discovered Mycobacterial Pathogen Isolated from Laboratory Colonies of Xenopus Species with Lethal Infections Produces a Novel Form of Mycolactone, the Mycobacterium ulcerans Macrolide Toxin

    Armand Mve-Obiang;Richard E. Lee;Edward S. Umstot;Kristin A. Trott

  • Early tissue interactions leading to embryonic lens formation in Xenopus laevis.

    Jonathan J. Henry;Robert M. Grainger

  • Inductive interactions in the spatial and temporal restriction of lens-forming potential in embryonic ectoderm of Xenopus laevis.

    Jonathan J. Henry;Robert M. Grainger

  • Gene activation during early stages of lens induction in Xenopus

    C.A. Zygar;T.L. Cook;R.M. Grainger

  • High-throughput transgenesis in Xenopus using I-SceI meganuclease

    Hajime Ogino;William B McConnell;Robert M Grainger

  • The development of Xenopus tropicalis transgenic lines and their use in studying lens developmental timing in living embryos

    Martin F. Offield;Nicholas Hirsch;Robert M. Grainger

  • A labile period in the determination of the anterior-posterior axis during early neural development in Xenopus.

    Margaret S. Saha;Robert M. Grainger

  • Changes in neural and lens competence in Xenopus ectoderm: evidence for an autonomous developmental timer

    M. Servetnick;R.M. Grainger

  • Highly efficient transgenesis in Xenopus tropicalis using I-SceI meganuclease

    Hajime Ogino;William B. McConnell;Robert M. Grainger

  • Cas9-based genome editing in Xenopus tropicalis.

    Takuya Nakayama;Ira L. Blitz;Margaret B. Fish;Akinleye O. Odeleye

  • Vertebrate eye development.

    Margaret S. Saha;Marc Servetnick;Robert M. Grainger

Frequent Co-Authors

Richard M. Harland
Richard M. Harland University of California, Berkeley
Daniel S. Rokhsar
Daniel S. Rokhsar University of California, Berkeley
Inna Dubchak
Inna Dubchak Lawrence Berkeley National Laboratory
Derek L. Stemple
Derek L. Stemple Camena Bioscience
Erika Lindquist
Erika Lindquist United States Department of Energy
Veronica van Heyningen
Veronica van Heyningen University College London
Jeremy Schmutz
Jeremy Schmutz Lawrence Berkeley National Laboratory
Igor V. Grigoriev
Igor V. Grigoriev Lawrence Berkeley National Laboratory
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital

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