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Biology and Biochemistry

D-Index
77
Citations
23171
World Ranking
4742
National Ranking
2297

Overview

Aris N. Economides is affiliated with Regeneron in the United States and specializes in medical research with a focus on genetics and molecular biology. Their work spans across several important fields, primarily Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Genetics, Molecular Biology, Rheumatology, Pulmonary and Respiratory Medicine, and Hematology.

Their research topics cover a diverse range of areas including:

  • Heterotopic Ossification and Related Conditions
  • Medical Imaging and Pathology Studies
  • Genetic Associations and Epidemiology
  • Parathyroid Disorders and Treatments
  • Genomics and Rare Diseases
  • Liver Disease Diagnosis and Treatment
  • Lysosomal Storage Disorders Research

Aris N. Economides has contributed to a number of publications in notable scientific venues. Their frequent publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • Bone
  • Proceedings of the National Academy of Sciences
  • Journal of the Endocrine Society

The scientist has collaborated regularly with several co-authors, among them:

  • John D. Overton
  • Jeffrey G. Reid
  • Alan R. Shuldiner
  • Luca A. Lotta
  • Aris Baras

Among their recent published papers are:

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis, 2020, Nature Genetics
  • Exome sequencing and characterization of 49,960 individuals in the UK Biobank, 2020, Nature
  • Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank, 2021, Nature Genetics
  • Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity, 2021, Science
  • Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease, 2022, Nature Genetics

Best Publications

  • Bone morphogenetic proteins, their antagonists, and the skeleton.

    Ernesto Canalis;Ernesto Canalis;Aris N. Economides;Elisabetta Gazzerro;Elisabetta Gazzerro

  • Neural induction by the secreted polypeptide noggin

    Teresa M. Lamb;Anne K. Knecht;William C. Smith;Scott E. Stachel

  • The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

    David R Hsu;Aris N Economides;Xiaorong Wang;Peter M Eimon

  • High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

    David M Valenzuela;Andrew J Murphy;David Frendewey;Nicholas W Gale

  • The bone marrow microenvironment at single-cell resolution.

    Anastasia N. Tikhonova;Igor Dolgalev;Hai Hu;Kishor K Sivaraj

  • Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

    Jay Groppe;Jason Greenwald;Ezra Wiater;Joaquin Rodriguez-Leon

  • Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2

    Bo Gao;Hai Song;Kevin Bishop;Gene Elliot

  • Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

    Luca Grumolato;Guizhong Liu;Phyllus Mong;Raksha Mudbhary

  • Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

    Frederick E. Dewey;Michael F. Murray;John D. Overton;Lukas Habegger

  • Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy

    Ka-Man V. Lai;Michael Gonzalez;William T. Poueymirou;William O. Kline

  • Cytokine traps: multi-component, high-affinity blockers of cytokine action

    Aris N. Economides;Laura Rocco Carpenter;John S. Rudge;Vivien Wong

  • RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.

    Evangelos Pefanis;Jiguang Wang;Gerson Rothschild;Junghyun Lim

  • Exome sequencing and characterization of 49,960 individuals in the UK Biobank.

    Cristopher V Van Hout;Ioanna Tachmazidou;Ioanna Tachmazidou;Joshua D Backman;Joshua D Hoffman

  • Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin.

    Etsuko Abe;Matsuo Yamamoto;Yasuto Taguchi;Beata Lecka‐Czernik

  • The BMP antagonist noggin regulates cranial suture fusion.

    Stephen M. Warren;Lisa J. Brunet;Richard M. Harland;Aris N. Economides

  • ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

    Sarah J. Hatsell;Vincent Idone;Dana M. Alessi Wolken;Lily Huang

  • The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb

    R. Merino;J. Rodriguez-Leon;D. Macias;Y. Ganan

  • The mammalian gene function resource: the international knockout mouse consortium

    Allan Bradley;Konstantinos Anastassiadis;Abdelkader Ayadi;James F. Battey

  • Morphogenesis of Digits in the Avian Limb Is Controlled by FGFs, TGFβs, and Noggin through BMP Signaling

    Ramón Merino;Yolanda Gañan;Domingo Macias;Aris N. Economides

  • Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients.

    Stephenie Paine-Saunders;Beth L. Viviano;Aris N. Economides;Scott Saunders

Frequent Co-Authors

George D. Yancopoulos
George D. Yancopoulos Regeneron (United States)
Andrew J. Murphy
Andrew J. Murphy St. Jude Children's Research Hospital
Ernesto Canalis
Ernesto Canalis University of Connecticut Health Center
David M. Valenzuela
David M. Valenzuela Regeneron (United States)
Nicholas W. Gale
Nicholas W. Gale Regeneron (United States)
David J. Carey
David J. Carey Geisinger Health System
Steven A. Goldman
Steven A. Goldman University of Rochester Medical Center
Vicki Rosen
Vicki Rosen Harvard University
Alan R. Shuldiner
Alan R. Shuldiner University of Maryland, Baltimore
Richard M. Harland
Richard M. Harland University of California, Berkeley

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