Michael F. Dunn

Research.com Recognitions

• 1997 - Fellow of the American Association for the Advancement of Science (AAAS)
• 1991 - Fellow of the American Society of Mechanical Engineers
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians

Overview

Best Publications

• Zinc–Ligand Interactions Modulate Assembly and Stability of the Insulin Hexamer – A Review

  Michael F. Dunn

  478
  Citations

• Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis.

  Unknown

  342
  Citations

• The tryptophan synthase bienzyme complex transfers indole between the alpha- and beta-sites via a 25-30 A long tunnel.

  Michael F. Dunn;Valentin Aguilar;Peter Brzovic;William F. Drewe

  226
  Citations

• Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin.

  Niels C. Kaarsholm;Hui Chong Ko;Michael F. Dunn

  212
  Citations

• Tryptophan synthase: the workings of a channeling nanomachine.

  Michael F. Dunn;Dimitri Niks;Huu Ngo;Thomas R.M. Barends

  209
  Citations

• Mechanistic studies on equine liver alcohol dehydrogenase. I. The stoichiometry relationship of the coenzyme binding sites to the catalytic sites active in the reduction of aromatic aldehydes in the transient state.

  Sidney A. Bernhard;Michael F. Dunn;Pier L. Luisi;Poul Schack

  200
  Citations

• Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex.

  Michael F. Dunn

  194
  Citations

• Protein architecture, dynamics and allostery in tryptophan synthase channeling

  Peng Pan;Eilika Woehl;Michael F. Dunn

  137
  Citations

• Detection and identification of intermediates in the reaction of L-serine with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy.

  William Frederick Drewe;Michael F. Dunn

  136
  Citations

• On the relationship of zinc ion to the structure and function of the 7S nerve growth factor protein.

  Scott E. Pattison;Michael F. Dunn

  133
  Citations

• Role of the proximal ligand in peroxidase catalysis. Crystallographic, kinetic, and spectral studies of cytochrome c peroxidase proximal ligand mutants.

  Kalidip Choudhury;Munirathiram Sundaramoorthy;A. Hickman;T. Yonetani

  130
  Citations

• Characterization of precrystallization aggregation of canavalin by dynamic light scattering

  W. Kadima;A. McPherson;M.F. Dunn;F.A. Jurnak

  127
  Citations

• Insulin-metal ion interactions: the binding of divalent cations to insulin hexamers and tetramers and the assembly of insulin hexamers.

  Frederick D. Coffman;Michael F. Dunn

  122
  Citations

• Mechanisms of Stabilization of the Insulin Hexamer through Allosteric Ligand Interactions

  S Rahuel-Clermont;C A French;N C Kaarsholm;M F Dunn

  119
  Citations

• Allosteric interactions coordinate catalytic activity between successive metabolic enzymes in the tryptophan synthase bienzyme complex.

  Peter S. Brzović;Khiet Ngo;Michael F. Dunn

  118
  Citations

• Reaction mechanism of Escherichia coli cystathionine gamma-synthase: direct evidence for a pyridoxamine derivative of vinylglyoxylate as a key intermediate in pyridoxal phosphate dependent gamma-elimination and gamma-replacement reactions.

  Peter Brzovic;Elizabeth Litzenberger Holbrook;Ronald C. Greene;Michael F. Dunn

  110
  Citations

• Characterization of the reaction of L-serine and indole with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy

  William Frederick Drewe;Michael F. Dunn

  108
  Citations

• Spectroscopic signatures of the T to R conformational transition in the insulin hexamer.

  M. Roy;M. Roy;M. L. Brader;R. W.-K. Lee;N. C. Kaarsholm

  108
  Citations

• Evidence that mutations in a loop region of the alpha-subunit inhibit the transition from an open to a closed conformation in the tryptophan synthase bienzyme complex.

  Peter S. Brzovic;Yoshihiro Sawa;C. Craig Hyde;Edith W. Miles

  107
  Citations

• X-ray structure of an unusual Ca2+ site and the roles of Zn2+ and Ca2+ in the assembly, stability, and storage of the insulin hexamer.

  Christopher P. Hill;Zbigniew Dauter;Zbigniew Dauter;Eleanor J. Dodson;Guy G. Dodson

  98
  Citations

• Rapid kinetic evidence for adduct formation between the substrate analog p-nitroso-N,N-dimethylaniline and reduced nicotinamide-adenine dinucleotide during enzymic reduction.

  M. F. Dunn;Sidney A. Bernhard

  97
  Citations