Manuel Fresno mostly deals with Molecular biology, Cell biology, Immunology, T cell and Tumor necrosis factor alpha. He has researched Molecular biology in several fields, including Jurkat cells, Transcription factor, Transactivation, IκBα and Cyclooxygenase. His study in Cell biology is interdisciplinary in nature, drawing from both Secretion, Peptide sequence, Cyclosporin a and Cytoskeleton.
His studies in Immunology integrate themes in fields like Heart disease, Myocarditis, Disease and Virology. His T cell research includes themes of Myeloid, Spleen, Lymphokine and Biochemistry. His Tumor necrosis factor alpha study combines topics from a wide range of disciplines, such as Macrophage, Cytokine and Transfection.
The scientist’s investigation covers issues in Molecular biology, Immunology, Trypanosoma cruzi, Cell biology and Virology. His biological study spans a wide range of topics, including Tumor necrosis factor alpha, Jurkat cells, T cell, Biochemistry and Antigen. His studies examine the connections between Tumor necrosis factor alpha and genetics, as well as such issues in Cytokine, with regards to Cell culture.
The concepts of his T cell study are interwoven with issues in Myeloid, Internal medicine, Cytotoxic T cell and Endocrinology. His Trypanosoma cruzi research is multidisciplinary, incorporating perspectives in Genetics, Myocarditis, Chagas disease, Macrophage and Monoclonal antibody. He has included themes like Cell adhesion and NFAT in his Cell biology study.
His scientific interests lie mostly in Trypanosoma cruzi, Immune system, Immunology, Chagas disease and Cancer research. His Trypanosoma cruzi study also includes fields such as
His Receptor research focuses on Acquired immune system and how it relates to Cell biology. His Flow cytometry study also includes
His primary areas of investigation include Immunology, Cancer research, Inflammation, Immune system and Chagas disease. His Immunology study combines topics in areas such as Infectious disease, Disease and Entamoeba gingivalis. He works mostly in the field of Cancer research, limiting it down to concerns involving Kinase and, occasionally, Cytokine secretion and Phosphatase.
His Inflammation study integrates concerns from other disciplines, such as PI3K/AKT/mTOR pathway, Signal transduction, Cell biology, Innate immune system and ATP synthase. Manuel Fresno interconnects Spleen, Gene expression and EBI3 in the investigation of issues within Immune system. The various areas that Manuel Fresno examines in his Chagas disease study include Asymmetric dimethylarginine, Arginine, Nitric oxide, Trypanosoma cruzi and Parasitemia.
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The role of tumour necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system
Ma Angeles Muñoz-Fernández;Manuel Fresno.
Progress in Neurobiology (1998)
Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism.
M A Muñoz-Fernández;M A Fernández;M Fresno.
European Journal of Immunology (1992)
Inhibition of Translation in Eukaryotic Systems by Harringtonine
Manuel Fresno;Antonio Jiménez;David Vázquez.
FEBS Journal (1977)
An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes
Miguel A. Íñiguez;Sara Martı́nez-Martı́nez;Carmen Punzón;Juan Miguel Redondo.
Journal of Biological Chemistry (2000)
Cyclooxygenase-2: a therapeutic target in angiogenesis
Miguel A Iñiguez;Antonio Rodrı́guez;Olga V Volpert;Manuel Fresno.
Trends in Molecular Medicine (2003)
Induction of Cyclooxygenase-2 on Activated T Lymphocytes: Regulation of T Cell Activation by Cyclooxygenase-2 Inhibitors
Miguel A. Iñiguez;Carmen Punzón;Manuel Fresno.
Journal of Immunology (1999)
Immunosuppression during acute Trypanosoma cruzi infection : involvement of Ly6G (Gr1^+)CD11b^+ immature myeloid suppressor cells
Oscar Goñi;Pilar Alcaide;Manuel Fresno.
International Immunology (2002)
Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-α and IFN-γ through a nitric oxide-dependent mechanism
Maria Angeles Muñoz-Fernández;Monica A. Fernández;Manuel Fresno.
Immunology Letters (1992)
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression
Enrique Lara-Pezzi;Maria Victoria Gómez-Gaviro;Beatriz G. Gálvez;Emilia Mira.
Journal of Clinical Investigation (2002)
Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice
Iñigo Angulo;Iñigo Angulo;Federico Gómez de las Heras;Federico Gómez de las Heras;José F. Garcı́a-Bustos;José F. Garcı́a-Bustos;Domingo Gargallo;Domingo Gargallo.
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