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Microbiology

D-Index
74
Citations
17070
World Ranking
1597
National Ranking
36

Overview

Manuel Fresno is affiliated with the Autonomous University of Madrid in Spain and focuses on research primarily within the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their work covers several subfields, including Immunology, Epidemiology, Infectious Diseases, Molecular Biology, and Public Health, Environmental and Occupational Health.

The main topics of Manuel Fresno's research activity include:

  • Trypanosoma species research and implications
  • Research on Leishmaniasis Studies
  • Immune Response and Inflammation
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Immune cells in cancer
  • COVID-19 Impact on Reproduction

Frequent co-authors in Fresno's publications are:

  • Núria Gironès
  • Alfonso Herreros-Cabello
  • Francisco Callejas-Hernández
  • Konstantinos Stamatakis
  • María del Carmen Lapo Maza

Manuel Fresno has published extensively in several scientific venues, notably:

  • Frontiers in Immunology
  • Scientific Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences
  • Frontiers in Cellular and Infection Microbiology

Key recent papers authored include:

  • "Trypanosoma Cruzi Genome: Organization, Multi-Gene Families, Transcription, and Biological Implications" (2020), published in Genes
  • "Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS" (2022), published in Frontiers in Immunology
  • "Is Covid-19 Severity Associated With ACE2 Degradation?" (2022), published in Frontiers in Drug Discovery
  • "Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer" (2020), published in Frontiers in Pharmacology
  • "Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS-CoV-2 spike protein" (2021), published in EMBO Molecular Medicine

Manuel Fresno's research addresses various aspects of immunology and infectious diseases, with notable attention to Trypanosoma species and related parasitic diseases, as well as COVID-19 and immune responses linked to viral infections and cancer.

Best Publications

  • Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a Roles of the Nuclear Factor of Activated T Cells and Cyclooxygenase 2

    Gabriela L. Hernández;Olga V. Volpert;Miguel A. Iñiguez;Elisa Lorenzo

  • The role of tumour necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system

    Ma Angeles Muñoz-Fernández;Manuel Fresno

  • Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism.

    M A Muñoz-Fernández;M A Fernández;M Fresno

  • Inhibition of Translation in Eukaryotic Systems by Harringtonine

    Manuel Fresno;Antonio Jiménez;David Vázquez

  • An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes

    Miguel A. Íñiguez;Sara Martı́nez-Martı́nez;Carmen Punzón;Juan Miguel Redondo

  • Cyclooxygenase-2: a therapeutic target in angiogenesis

    Miguel A Iñiguez;Antonio Rodrı́guez;Olga V Volpert;Manuel Fresno

  • Prostaglandin E2 and T cells: friends or foes?

    Vinatha Sreeramkumar;Manuel Fresno;Natalia Cuesta

  • Induction of Cyclooxygenase-2 on Activated T Lymphocytes: Regulation of T Cell Activation by Cyclooxygenase-2 Inhibitors

    Miguel A. Iñiguez;Carmen Punzón;Manuel Fresno

  • Immunosuppression during acute Trypanosoma cruzi infection : involvement of Ly6G (Gr1^+)CD11b^+ immature myeloid suppressor cells

    Oscar Goñi;Pilar Alcaide;Manuel Fresno

  • Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-α and IFN-γ through a nitric oxide-dependent mechanism

    Maria Angeles Muñoz-Fernández;Monica A. Fernández;Manuel Fresno

  • The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression

    Enrique Lara-Pezzi;Maria Victoria Gómez-Gaviro;Beatriz G. Gálvez;Emilia Mira

  • Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice

    Iñigo Angulo;Iñigo Angulo;Federico Gómez de las Heras;Federico Gómez de las Heras;José F. Garcı́a-Bustos;José F. Garcı́a-Bustos;Domingo Gargallo;Domingo Gargallo

  • Cytokines in the Pathogenesis of and Protection against Malaria

    Iñigo Angulo;Manuel Fresno

  • T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

    Michael H. Shaw;Thornik Reimer;Carmen Sánchez-Valdepeñas;Neil Warner

  • Toll-like receptors, inflammation, metabolism and obesity.

    Manuel Fresno;Ruth Alvarez;Natalia Cuesta

  • Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization.

    Laura Formentini;Laura Formentini;Fulvio Santacatterina;Fulvio Santacatterina;Cristina Núñez de Arenas;Cristina Núñez de Arenas;Konstantinos Stamatakis

  • Inhibition of Nuclear Factor κB Activation by a Virus-encoded IκB-like Protein

    Yolanda Revilla;Mario Callejo;Javier M. Rodrı́guez;Esther Culebras

  • Cytokines and infectious diseases

    Manuel Fresno;Manfred Kopf;Luis Rivas

  • IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages.

    Virginia Vila-del Sol;Carmen Punzón;Manuel Fresno

  • Carcinoma-associated fibroblasts derive from mesothelial cells via mesothelial-to-mesenchymal transition in peritoneal metastasis

    Pilar Sandoval;Jose Antonio Jiménez-Heffernan;Ángela Rynne-Vidal;María Luisa Pérez-Lozano

  • Prostanoid signal transduction and gene expression in the endothelium: Role in cardiovascular diseases

    Arántzazu Alfranca;Arántzazu Alfranca;Miguel A. Iñiguez;Manuel Fresno;Juan Miguel Redondo;Juan Miguel Redondo

  • Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-kappaB and nuclear factor of activated T cells activation.

    J L Jimenez;C Punzón;J Navarro;M A Muñoz-Fernández

Frequent Co-Authors

Francisco Sánchez-Madrid
Francisco Sánchez-Madrid Autonomous University of Madrid
Balbino Alarcón
Balbino Alarcón Spanish National Research Council
Juan Miguel Redondo
Juan Miguel Redondo Spanish National Centre for Cardiovascular Research
David Vazquez
David Vazquez Autonomous University of Madrid
Miguel A. Alonso
Miguel A. Alonso Spanish National Research Council
Luis Carrasco
Luis Carrasco Centro de Biología Molecular Severo Ochoa
Manuel López-Cabrera
Manuel López-Cabrera Spanish National Research Council
Gema Moreno-Bueno
Gema Moreno-Bueno The University of Texas MD Anderson Cancer Center
Manuel Soto
Manuel Soto Autonomous University of Madrid
Santiago Mas-Coma
Santiago Mas-Coma University of Valencia

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