D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Microbiology D-index 67 Citations 12,149 231 World Ranking 1433 National Ranking 43

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Immune system

Manuel Fresno mostly deals with Molecular biology, Cell biology, Immunology, T cell and Tumor necrosis factor alpha. He has researched Molecular biology in several fields, including Jurkat cells, Transcription factor, Transactivation, IκBα and Cyclooxygenase. His study in Cell biology is interdisciplinary in nature, drawing from both Secretion, Peptide sequence, Cyclosporin a and Cytoskeleton.

His studies in Immunology integrate themes in fields like Heart disease, Myocarditis, Disease and Virology. His T cell research includes themes of Myeloid, Spleen, Lymphokine and Biochemistry. His Tumor necrosis factor alpha study combines topics from a wide range of disciplines, such as Macrophage, Cytokine and Transfection.

His most cited work include:

  • The role of tumour necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system (349 citations)
  • Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. (269 citations)
  • Inhibition of Translation in Eukaryotic Systems by Harringtonine (199 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Molecular biology, Immunology, Trypanosoma cruzi, Cell biology and Virology. His biological study spans a wide range of topics, including Tumor necrosis factor alpha, Jurkat cells, T cell, Biochemistry and Antigen. His studies examine the connections between Tumor necrosis factor alpha and genetics, as well as such issues in Cytokine, with regards to Cell culture.

The concepts of his T cell study are interwoven with issues in Myeloid, Internal medicine, Cytotoxic T cell and Endocrinology. His Trypanosoma cruzi research is multidisciplinary, incorporating perspectives in Genetics, Myocarditis, Chagas disease, Macrophage and Monoclonal antibody. He has included themes like Cell adhesion and NFAT in his Cell biology study.

He most often published in these fields:

  • Molecular biology (31.70%)
  • Immunology (24.91%)
  • Trypanosoma cruzi (23.77%)

What were the highlights of his more recent work (between 2016-2021)?

  • Trypanosoma cruzi (23.77%)
  • Immune system (12.45%)
  • Immunology (24.91%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Trypanosoma cruzi, Immune system, Immunology, Chagas disease and Cancer research. His Trypanosoma cruzi study also includes fields such as

  • Whole genome sequencing together with Transcription,
  • Gene expression, which have a strong connection to NADPH oxidase, Parasite load, Molecular biology, Proinflammatory cytokine and CD8. He has researched Immune system in several fields, including Serology, Antibody, Spleen, Receptor and Flow cytometry.

His Receptor research focuses on Acquired immune system and how it relates to Cell biology. His Flow cytometry study also includes

  • Virology and Jurkat cells most often made with reference to Statistics & numerical data,
  • Monoclonal antibody which is related to area like T cell. His Cancer research research includes elements of Cancer, Ovarian cancer, Kinase, MAP3K14 and Inflammation.

Between 2016 and 2021, his most popular works were:

  • Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization. (68 citations)
  • Physiological Translocation of Lactic Acid Bacteria during Pregnancy Contributes to the Composition of the Milk Microbiota in Mice (32 citations)
  • Genomic assemblies of newly sequenced Trypanosoma cruzi strains reveal new genomic expansion and greater complexity. (26 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Immune system

His primary areas of investigation include Immunology, Cancer research, Inflammation, Immune system and Chagas disease. His Immunology study combines topics in areas such as Infectious disease, Disease and Entamoeba gingivalis. He works mostly in the field of Cancer research, limiting it down to concerns involving Kinase and, occasionally, Cytokine secretion and Phosphatase.

His Inflammation study integrates concerns from other disciplines, such as PI3K/AKT/mTOR pathway, Signal transduction, Cell biology, Innate immune system and ATP synthase. Manuel Fresno interconnects Spleen, Gene expression and EBI3 in the investigation of issues within Immune system. The various areas that Manuel Fresno examines in his Chagas disease study include Asymmetric dimethylarginine, Arginine, Nitric oxide, Trypanosoma cruzi and Parasitemia.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The role of tumour necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system

Ma Angeles Muñoz-Fernández;Manuel Fresno.
Progress in Neurobiology (1998)

494 Citations

Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism.

M A Muñoz-Fernández;M A Fernández;M Fresno.
European Journal of Immunology (1992)

411 Citations

Inhibition of Translation in Eukaryotic Systems by Harringtonine

Manuel Fresno;Antonio Jiménez;David Vázquez.
FEBS Journal (1977)

336 Citations

An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes

Miguel A. Íñiguez;Sara Martı́nez-Martı́nez;Carmen Punzón;Juan Miguel Redondo.
Journal of Biological Chemistry (2000)

292 Citations

Cyclooxygenase-2: a therapeutic target in angiogenesis

Miguel A Iñiguez;Antonio Rodrı́guez;Olga V Volpert;Manuel Fresno.
Trends in Molecular Medicine (2003)

268 Citations

Induction of Cyclooxygenase-2 on Activated T Lymphocytes: Regulation of T Cell Activation by Cyclooxygenase-2 Inhibitors

Miguel A. Iñiguez;Carmen Punzón;Manuel Fresno.
Journal of Immunology (1999)

265 Citations

Immunosuppression during acute Trypanosoma cruzi infection : involvement of Ly6G (Gr1^+)CD11b^+ immature myeloid suppressor cells

Oscar Goñi;Pilar Alcaide;Manuel Fresno.
International Immunology (2002)

259 Citations

Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-α and IFN-γ through a nitric oxide-dependent mechanism

Maria Angeles Muñoz-Fernández;Monica A. Fernández;Manuel Fresno.
Immunology Letters (1992)

250 Citations

The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression

Enrique Lara-Pezzi;Maria Victoria Gómez-Gaviro;Beatriz G. Gálvez;Emilia Mira.
Journal of Clinical Investigation (2002)

241 Citations

Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice

Iñigo Angulo;Iñigo Angulo;Federico Gómez de las Heras;Federico Gómez de las Heras;José F. Garcı́a-Bustos;José F. Garcı́a-Bustos;Domingo Gargallo;Domingo Gargallo.
Blood (2000)

237 Citations

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